PD Dr. Constanze Buhrmann

Akademische Oberrätin, Lehrbeauftragte
Anatomie und Zellbiologie
Telefon: +49 (0) 821 598 - 3139
E-Mail: constanze.buhrmann@med.uni-augsburg.de
Raum: 1005 (Sigma-Technopark Gebäude 10)
Adresse: Werner-von-Siemens-Straße 6 (Sigma Technopark), 86159 Augsburg

Forschungsschwerpunkt AG 5 (Buhrmann)

Einfluss von Nahrungsergänzungsmitteln auf Entzündung und Alterungsprozesse

Die AG 5 untersucht die Wirkungsweise natürlicher Polyphenole, wie z. B. Resveratrol und Curcumin, im Rahmen von an entzündlichen Prozessen beteiligten Signaltransduktionskaskaden und an altersbedingten Umbauprozessen. Hierdurch soll der prophylaktische Einfluss natürlicher Nahrungsbestandteile wie Resveratrol auf umweltbedingte Erkrankungen wie z. B. Tumorerkrankungen des Kolons, mechanistisch verstanden werden. Desweitern untersuchen wir den Einfluss natürlicher Polyphenole auf die Interaktion der Thymozyten, T-Zellen und Adipozyten im Rahmen der mit dem Lebensalter fortschreitenden Involution des Thymus.

 

Fokus:

Resveratol vermittelte Effekte auf die Alterung des Thymus

Lebenslauf

2020-

Akademische Rätin am Lehrstuhl für Anatomie und Zellbiologie, Medizinische Fakultät, Universität Augsburg

 

2019

Fachanatomin Anatomische Gesellschaft

 

2015-2020

Akademische Rätin am Institut für Anatomie der Ludwig Maximilians Universität München

 

2015

Habilitation und Lehrauftrag für das Fachgebiet Anatomie und Zellbiologie an der Medizinischen Fakultät der Ludwig Maximilians Universität München

 

2013

Zertifikat „Hochschullehre Bayern-Grundstufe“

 

2006-2015

Wissenschaftliche Mitarbeiterin am Institut für Anatomie der Ludwig Maximilians Universität München

 

2005-2006

Assistenzärztin in der Pferdepraxis Drs. Detlef/Flotow in Eutin, Ostholstein

 

2004-2005

Promotion (Dr. med. vet.) im Department für klinische Veterinärmedizin Abt. Pferdeklinik der Vetsuisse-Fakultät der Universität Bern, Schweiz

 

1997-2003

Studium der Tiermedizin an der Ludwig Maximilians Universität München

Mitgliedschaften

  • Mitglied der Anatomischen Gesellschaft

Publikationen

Buhrmann, Constanze
2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2021

Buhrmann Constanze, Brockmueller Aranka, Mueller Anna-Lena, Shayan Parviz, Shakibaei Mehdi. Curcumin attenuates environment-derived osteoarthritis by Sox9/NF-kB signaling axis. https://doi.org/10.3390/ijms22147645
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Buhrmann Constanze, Brockmueller Aranka, Mueller Anna-Lena, Shayan Parviz, Shakibaei Mehdi. Curcumin attenuates environment-derived osteoarthritis by Sox9/NF-kB signaling axis. https://doi.org/10.3390/ijms22147645
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Buhrmann Constanze, Brockmueller Aranka, Harsha Choudhary, Kunnumakkara Ajaikumar B., Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that tumor microenvironment initiates epithelial-to-mesenchymal transition and calebin a can suppress it in colorectal cancer cells. https://doi.org/10.3389/fphar.2021.699842
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Bordoloi Devivasha, Padmavathi Ganesan, Banik Kishore, Devi Khwairakpam Amrita, Harsha Choudhary, Girisa Sosmitha, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B.. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. https://doi.org/10.1007/s11010-021-04060-1
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Buhrmann Constanze, Kunnumakkara Ajaikumar B., Kumar Aviral, Samec Marek, Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi. Multitargeting effects of calebin A on malignancy of CRC cells in multicellular tumor microenvironment. https://doi.org/10.3389/fonc.2021.650603
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Buhrmann Constanze, Aggarwal B. B., Shakibaei M.. Resveratrol and chronic diseases: lessons learned from bedside. https://doi.org/10.1142/11520
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2020

Buhrmann Constanze, Kunnumakkara Ajaikumar, Popper Bastian, Majeed Muhammed, Aggarwal Bharat, Shakibaei Mehdi. Calebin A potentiates the effect of 5-FU and TNF-β (lymphotoxin α) against human colorectal cancer cells: potential role of NF-κB. https://doi.org/10.3390/ijms21072393
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Koklesova Lenka, Liskova Alena, Samec Marek, Buhrmann Constanze, Samuel Samson Mathews, Varghese Elizabeth, Ashrafizadeh Milad, Najafi Masoud, Shakibaei Mehdi, Büsselberg Dietrich, Giordano Frank A., Golubnitschaja Olga, Kubatka Peter. Carotenoids in cancer apoptosis - the road from bench to bedside and back. https://doi.org/10.3390/cancers12092425
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Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2. https://doi.org/10.1007/s00441-020-03188-8
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Samec Marek, Liskova Alena, Koklesova Lenka, Samuel Samson Mathews, Zhai Kevin, Buhrmann Constanze, Varghese Elizabeth, Abotaleb Mariam, Qaradakhi Tawar, Zulli Anthony, Kello Martin, Mojzis Jan, Zubor Pavol, Kwon Taeg Kyu, Shakibaei Mehdi, Büsselberg Dietrich, Sarria Gustavo R., Golubnitschaja Olga, Kubatka Peter. Flavonoids against the Warburg phenotype - concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism. https://doi.org/10.1007/s13167-020-00217-y
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Buhrmann Constanze, Honarvar Ali, Setayeshmehr Mohsen, Karbasi Saeed, Shakibaei Mehdi, Valiani Ali. Herbal remedies as potential in cartilage tissue engineering: an overview of new therapeutic approaches and strategies. https://doi.org/10.3390/molecules25133075
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Bordoloi Devivasha, Banik Kishore, Vikkurthi Rajesh, Thakur Krishan Kumar, Padmavathi Ganesan, Sailo Bethsebie Lalduhsaki, Girisa Sosmitha, Chinnathambi Arunachalam, Alahmadi Tahani Awad, Alharbi Sulaiman Ali, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B.. Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis. https://doi.org/10.1016/j.lfs.2020.118475
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Shaqura Mohammed, Li Li, Mohamed Doaa M., Li Xiongjuan, Treskatsch Sascha, Buhrmann Constanze, Shakibaei Mehdi, Beyer Antje, Mousa Shaaban A., Schäfer Michael. Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain. https://doi.org/10.1186/s12974-020-01864-8
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Farkhondeh Tahereh, Mehrpour Omid, Buhrmann Constanze, Pourbagher-Shahri Ali Mohammad, Shakibaei Mehdi, Samarghandian Saeed. Organophosphorus compounds and MAPK signaling pathways. https://doi.org/10.3390/ijms21124258
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Buhrmann Constanze, Shayan Parviz, Brockmueller Aranka, Shakibaei Mehdi. Resveratrol suppresses cross-talk between colorectal cancer cells and stromal cells in multicellular tumor microenvironment: a bridge between in vitro and in vivo tumor microenvironment study. https://doi.org/10.3390/molecules25184292
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Buhrmann Constanze, Yazdi Mina, Bashiri Dezfouli Ali, Samani Sahraneshin Fazel, Ebrahimi Seyed Morteza, Hamidollah Ghaffari Seyed, Yaghmaie Marjan, Barin Abbas, Shakibaei Mehdi, Shayan Parviz. Significant decrease in the viability and tumor stem cell marker expression in tumor cell lines treated with curcumin. https://doi.org/10.1016/j.hermed.2020.100339
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Buhrmann Constanze, Shayan Parviz, Banik Kishore, Kunnumakkara Ajaikumar B., Kubatka Peter, Koklesova Lenka, Shakibaei Mehdi. Targeting NF-κB signaling by Calebin A, a compound of turmeric, in multicellular tumor microenvironment: potential role of apoptosis induction in CRC cells. https://doi.org/10.3390/biomedicines8080236
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2019

Buhrmann Constanze, Popper Bastian, Kunnumakkara Ajaikumar B., Aggarwal Bharat B., Shakibaei Mehdi. Evidence that Calebin A, a component of curcuma longa suppresses NF-κB mediated proliferation, invasion and metastasis of human colorectal cancer induced by TNF-β (lymphotoxin). https://doi.org/10.3390/nu11122904
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it. https://doi.org/10.1177/1535370218824538
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Kunnumakkara Ajaikumar, Aggarwal Bharat, Shakibaei Mehdi. Induction of the epithelial-to-mesenchymal transition of human colorectal cancer by human TNF-β (lymphotoxin) and its reversal by resveratrol. https://doi.org/10.3390/nu11030704
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2018

Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat, Shakibaei Mehdi. Resveratrol chemosensitizes TNF-β-induced survival of 5-FU-treated colorectal cancer cells. https://doi.org/10.3390/nu10070888
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2017

Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi. Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: comparison with TNF-α. https://doi.org/10.1371/journal.pone.0186993
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Buhrmann Constanze, Shayan Parviz, Goel Ajay, Shakibaei Mehdi. Resveratrol regulates colorectal cancer cell invasion by modulation of focal adhesion molecules. https://doi.org/10.3390/nu9101073
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2016

Buhrmann Constanze, Shayan Parviz, Popper Bastian, Goel Ajay, Shakibaei Mehdi. Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells. https://doi.org/10.3390/nu8030145
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Fellows Christopher R., Gauthaman Kalamegam, Pushparaj Peter N., Abbas Mohammed, Matta Csaba, Lewis Rebecca, Buhrmann Constanze, Shakibaei Mehdi, Mobasheri Ali. Stem cells in bone and articular cartilage tissue regeneration. https://doi.org/10.1007/978-3-319-40144-7_9
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2015

Toden Shusuke, Okugawa Yoshinaga, Jascur Thomas, Wodarz Dominik, Komarova Natalia L., Buhrmann Constanze, Shakibaei Mehdi, Boland C. Richard, Goel Ajay. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. https://doi.org/10.1093/carcin/bgv006
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Shakibaei Mehdi, Kraehe Patricia, Popper Bastian, Shayan Parviz, Goel Ajay, Buhrmann Constanze. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. https://doi.org/10.1186/s12885-015-1291-0
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Toden S., Okugawa Y., Buhrmann Constanze, Nattamai D., Anguiano E., Baldwin N., Shakibaei M., Boland C. R., Goel A.. Novel evidence for curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer. https://doi.org/10.1158/1940-6207.capr-14-0354
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Buhrmann Constanze, Shayan Parviz, Kraehe Patricia, Popper Bastian, Goel Ajay, Shakibaei Mehdi. Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. https://doi.org/10.1016/j.bcp.2015.08.105
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2014

Shakibaei Mehdi, Buhrmann Constanze, Kraehe Patricia, Shayan Parviz, Lueders Cora, Goel Ajay. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. https://doi.org/10.1371/journal.pone.0085397
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Buhrmann Constanze, Kraehe Patricia, Lueders Cora, Shayan Parviz, Goel Ajay, Shakibaei Mehdi. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. https://doi.org/10.1371/journal.pone.0107514
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Buhrmann Constanze, Busch Franziska, Shayan Parviz, Shakibaei Mehdi. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. https://doi.org/10.1074/jbc.m114.568790
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2013

Lorenz Wolfgang, Buhrmann Constanze, Mobasheri Ali, Lueders Cora, Shakibaei Mehdi. Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis. https://doi.org/10.1186/ar4291
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Buhrmann Constanze, Shayan Parviz, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. https://doi.org/10.1186/ar4393
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2012

Shakibaei Mehdi, Shayan Parviz, Busch Franziska, Aldinger Constance, Buhrmann Constanze, Lueders Cora, Mobasheri Ali. Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. https://doi.org/10.1371/journal.pone.0035712
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Mobasheri Ali, Kelly Sara, Clutterbuck Abigail L., Buhrmann Constanze, Shakibaei Mehdi. Three-dimensional, high-density and tissue engineered culture models of articular cartilage. https://doi.org/10.1002/9781119940685.ch16
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2011

Shakibaei M., Buhrmann Constanze, Mobasheri A.. Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro. https://doi.org/10.14670/HH-26.1173
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Buhrmann Constanze, Mobasheri Ali, Busch Franziska, Aldinger Constance, Stahlmann Ralf, Montaseri Azadeh, Shakibaei Mehdi. Curcumin modulates nuclear factor κB (NF-κB)-mediated inflammation in human tenocytesin vitro: role of the phosphatidylinositol 3-kinase/akt pathway. https://doi.org/10.1074/jbc.m111.256180
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Shakibaei Mehdi, Mobasheri Ali, Buhrmann Constanze. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. https://doi.org/10.1007/s12263-010-0179-5
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Mobasheri Ali, Richardson Stephen M., Hoyland Judith A., Buhrmann Constanze, Shakibaei Mehdi. From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of mesenchymal stem cells. https://doi.org/10.5772/23747
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Montaseri Azadeh, Busch Franziska, Mobasheri Ali, Buhrmann Constanze, Aldinger Constance, Rad Jafar Soleimani, Shakibaei Mehdi. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. https://doi.org/10.1371/journal.pone.0028663
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Shakibaei Mehdi, Buhrmann Constanze, Mobasheri Ali. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand RANKL activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells. https://doi.org/10.1074/jbc.m110.198713
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Schneider Philipp R. A., Buhrmann Constanze, Mobasheri Ali, Matis Ulrike, Shakibaei Mehdi. Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells. https://doi.org/10.1002/jor.21400
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2010

Buhrmann Constanze, Mobasheri Ali, Matis Ulrike, Shakibaei Mehdi. Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. https://doi.org/10.1186/ar3065
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Richardson Stephen M., Hoyland Judith A., Mobasheri Reza, Csaki Constanze, Shakibaei Mehdi, Mobasheri Ali. Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. https://doi.org/10.1002/jcp.21915
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2009

Seifarth Claudia, Buhrmann Constanze, Shakibaei M.. Anabolic actions of IGF-I and TGF-β1 on human articular chondrocytes in vitro: potential applications in tissue engineering. https://doi.org/10.14670/HH-24.1245
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Csaki Constanze, Matis U., Mobasheri A., Shakibaei M.. Co-culture of canine mesenchymal stem cells with primary bone-derived osteoblasts promotes osteogenic differentiation. https://doi.org/10.1007/s00418-008-0524-6
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Mobasheri A., Buhrmann Constanze, Clutterbuck A. L., Rahmanzadeh M., Shakibaei M.. Mesenchymal stem cells in connective tissue engineering and regenerative medicine for cartilage repair and osteoarthritis therapy. https://doi.org/10.14670/HH-24.347
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Csaki Constanze, Mobasheri Ali, Shakibaei Mehdi. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis. https://doi.org/10.1186/ar2850
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2008

Shakibaei Mehdi, Csaki Constanze, Mobasheri Ali. Diverse roles of integrin receptors in articular cartilage. https://doi.org/10.1007/978-3-540-78771-6
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Shakibaei M., Csaki Constanze, Rahmanzadeh M., Putz R.. Interaktion zwischen humanen Chondrozyten und extrazellulärer Matrix in vitro: ein Beitrag zur autologen Chondrozytentransplantation. https://doi.org/10.1007/s00132-008-1260-2
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Csaki Constanze, Schneider P. R. A., Shakibaei M.. Mesenchymal stem cells as a potential pool for cartilage tissue engineering. https://doi.org/10.1016/j.aanat.2008.07.007
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Csaki Constanze, Keshishzadeh Nerses, Fischer Karoline, Shakibaei Mehdi. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. https://doi.org/10.1016/j.bcp.2007.09.014
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Shakibaei Mehdi, Csaki Constanze, Nebrich Simone, Mobasheri Ali. Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. https://doi.org/10.1016/j.bcp.2008.05.029
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2007

Csaki Constanze, Matis U., Mobasheri A., Ye H., Shakibaei M.. Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study. https://doi.org/10.1007/s00418-007-0337-z
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