Forschungsprojekte

Die Seite befindet sich im Aufbau. Inhalte folgen in Kürze.

Publikationen

2021

 

Zhang, P., Schlecht, A., Wolf, J., Boneva, S., Laich, Y., Koch, J., Ludwig, F., Boeck, M., Thien, A., Härdtner, C., Kierdorf, K., Agostini, H., Schlunck, G.,Prinz, M., Hilgendorf, I., Wieghofer, P., Lange, C., (2021) The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation. J. Neuroinflammation, 18:215, doi: 0.1186/s12974-021-02230-y

 

Wieghofer, P., Hagemeyer, N., Sankowski, R., Schlecht, A., Staszewski, O., Gruber, M., Koch, J., Hausmann, A., Zhang, P., Boneva, S., Masuda, T., Hilgendorf, I., Goldmann, T., Böttcher, C., Priller, J., Rossi, F.M.V., Lange, C., Prinz, M., (2021) Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO J., doi: 10.15252/embj.2020105123

 

Schlecht, A., Zhang, P., Wolf. J., Thien, A., Rosmus, DD., Boneva, S., Schlunck, G., Lange, C., Wieghofer, P. (2021) Secreted phosphoprotein 1 expression in retinal mononuclear phagocytes links murine to human choroidal neovascularization. Front. Cell Dev. Biol., doi: 10.3389/fcell.2020.618598

 

Lindhorst, A., Raulien, N., Wieghofer, P., Eilers, J., Rossi, F.M.V., Bechmann, I., Gericke, M. (2021) Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages. Cell Death Dis., 12: 579

 

Zhuang, X., Schlunck, G., Wolf, J., Rosmus, DD, Bleul T, Luo R, Böhringer D, Wieghofer P, Lange C, Reinhard C, Lapp T (2021) Time- and Stimulus-Dependent Characteristics of Innate Immune Cells in Organ-Cultured Human Corneal Tissue. J Innate Immun. doi: 10.1159/000516669

 

 

2020

 

Boneva, S., Wolf, J., Rosmus, DD., Schlecht, A., Prinz, G., Laich, Y., Boeck, M., Zhang, P. Hilgendorf, I., Stahl, A., Reinhard, T., Bainbridge, J., Schlunck, G., Agostini, H., Wieghofer, P., Lange, C. (2020) Transcriptional Profiling Uncovers Human Hyalocytes as a Unique Innate Immune Cell Population. Front. Immunol. doi: 10.3389/fimmu.2020.567274

 

Brioschi, S., D'Errico, P., Janova, H., Wojcik, S.M., Meyer-Luehmann, M., Rajendran, L., Wieghofer, P., Paolicelli, R.C., Biber, K. (2020) Detection of synaptic proteins in microglia by flow cytometry. Front. Mol. Neurosci., doi: 10.3389/fnmol.2020.00149

 

Schlecht, A., Boneva, S., Gruber, M., Zhang, P., Horres, R., Bucher, F., Auw-Haedrich, C., Hansen, L., Stahl, A., Hilgendorf, I., Agostini, H., Wieghofer, P., Schlunck, G., Wolf, J., Lange, C. (2020) Transcriptomic Characterization of Human Choroidal Neovascular Membranes Identifies Calprotectin as a Novel Biomarker for Patients with Age-related Macular Degeneration. Am. J. Path.

 

Boeck, M., Thien, A., Wolf, J., Hagemeyer, N., Laich, Y., Yussuf, D., Backofen, R., Zhang, P., Boneva, S., Stahl, A., Hilgendorf, I., Agostini, H., Prinz, M., Wieghofer, P., Schlunck, G., Schlecht, A, Lange, C.. (2020) Temporo-spatial distribution and transcriptional profile of retinal microglia cells in the oxygen-induced retinopathy mouse model. Glia. 68(9):1859-1873

 

 

2018

 

Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Walle, L.V., Jordao M.J.C., Sze, M., Vikkula, HK., Demeestere, D., Van Imschoot, G., Scott, C.L., Hoste, E., Gonçalves, A., Guilliams, M., Lippens, S., Libert, C., Vandenbroucke, R.E., Kim, K.W., Jung, S., Callaerts-Vegh, Z., Callaerts, P., de Wit, J., Lamkanfi, M., Prinz, M., van Loo, G. (2018) A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nat. Commun. 9: 2036

 

Ajami, B., Samusik, N., Wieghofer, P., Ho, P.P., Crotti, A., Bjornson, Z., Prinz, M., Fantl, W., Nolan, G.P., Steinman, L. (2018) Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models. Nat. Neurosci. 4: 541–551

 

2016

 

Theurl, I., Hilgendorf, I., Nairz, M., Tymoszuk, P., Haschka, D.,
Asshoff, M., He, S., Gerhardt, M.L.S., Holderried, T.A.W., Seifert, M., Sopper, S., Fenn, A.M., Anzai, A., Rattik, S., McAlpine, C., Theurl, M., Wieghofer, P., Iwamoto, Y., Weber G.F., Harder, N.K., Chousterman, B.G., Arvedson T.L., McKee M., Wang F., Lutz O.M.D., Rezoagli, E., Babitt, J.L., Berra, L., Prinz, M., Nahrendorf, M., Weiss, G., Weissleder, R., Lin, H.Y., Swirski F.K. (2016). On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat. Med. 22: 945–951

 

Hagemeyer, N., Kierdorf, K., Frenzel, K., Xue, J., Ringelhan, M., Abdullah, Z., Godin, I., Wieghofer, P., Costa Jordão, M.J., Ulas, T., Yorgancioglu G., Rosenbauer, F., Knolle, P.A., Heikenwalder, M., Schultze, J.L. & Prinz, M. (2016). Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 35: 1730–1744

 

Goldmann, T., Wieghofer, P., Jordão, M.J., Prutek, F., Hagemeyer, N., Frenzel, K., Staszewski, O., Kierdorf, K., Amann, L., Krueger, M., Locatelli, G., Hochgarner, H., Zeiser, R., Epelman, S., Geissmann, F., Priller, J., Rossi, F., Bechmann, I., Kerschensteiner, M., Linnarsson, S., Jung, S., Prinz, M. (2016). Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17: 797–805

 

Ensan S., Li A., Degousee N., Besla R., Cosme J., Roufaiel M., El-Maklizi M., Williams J., Shikatani E., Li C., Lewis B., Robins L., Yun T.J., Lee J.S., Wieghofer P., Khattar R., Byrne J., Ouzounian M., Zavitz C.CJ., van Lookeren-Campagne M., Bauer C.M.T., Libby P., Husain M., Swirski F.K., Cheong C., Prinz M., Hilgendorf I., Randolph G., Epelman S., Gramolini A.O., Cybulsky M.I., Rubin B.B., Robbins C.S. (2016). Self-renewing resident arterial macrophages arise from embryonic CX3CR1 precursors and circulating monocytes immediately after birth. Nat. Immunol. 17: 159–168

 

2015

 

Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki,T., Higuchi, K., Morimoto, Y., Wieghofer, P., Okada, Y., Mori, Y., Sakoda, S., Saika, S., Yoshioka,Y., Komuro, I., Yamashita, T., Hirano, T., Prinz, M., Murakami, M. (2015). A pain-mediated neuralsignal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. eLife 4.

 

Erny, D., Hrabě de Angelis, A.L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., Schwierzeck, V., Utermöhlen, O., Chun, E., Garrett, W.S., McCoy, K.D., Diefenbach, A., Staeheli, P., Stecher, B., Amit, I., Prinz, M. (2015). Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci.18: 965–977.

 

Gao, L., Brenner, D., Llorens-Bobadilla, E., Saiz-Castro, G., Frank, T., Wieghofer, P., Hill, O., Thiemann, M., Karray, S., Prinz, M., Weishaupt, JH., Martin-Villalba, A. (2015). Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J. Exp. Med. 212(4): 469–80.

 

2014

 

Mc Guire, C., Elton, L., Wieghofer, P., Staal, J., Voet, S., Demeyer, A., Nagel, D., Krappmann, D., Prinz, M., Beyaert, R., van Loo, G. (2014). Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J. Neuroinflammation 11, 124.

 

2013

 

Goldmann, T., Wieghofer, P., Müller, P.F., Wolf, Y., Varol, D., Yona, S., Brendecke, S.M., Kierdorf, K., Staszewski, O., Datta, M., Luedde, T., Heikenwalder, M., Jung, S., Prinz, M. (2013). A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat. Neurosci. 16: 1618–1626.

 

Mc Guire, C., Wieghofer, P., Elton, L., Muylaert, D., Prinz, M., Beyaert, R., van Loo, G.

(2013). Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J. Immunol. 190: 2896–2903.

 

Funk, N., Wieghofer, P., Grimm, S., Schaefer, R., Bühring, H.-J., Gasser, T., and Biskup, S. (2013). Characterization of peripheral hematopoietic stem cells and monocytes in Parkinsons disease. Mov. Disord. 28: 392–395.

 

Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E.G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., Müller, DN., Luckow, B., Brocker, T., Debowski, K., Fritz, G., Opdenakker, G., Diefenbach, A., Biber, K., Heikenwalder, M., Geissmann, F., Rosenbauer, F., Prinz, M. (2013). Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat. Neurosci. 16: 273–280.

 

 

Übersichtsartikel

 

Tenbrock, L., Wolf, J., Boneva, S., Schlecht, A., Agostini, H., Wieghofer, P., Schlunck, G., and Lange, C. (2021). Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives. Cell Tissue Res.

 

Wieghofer P., Prinz M. (2016). Genetic manipulation of microglia during brain development and disease. Biochim. Biophys. Acta. 1862: 299–309.

 

Wieghofer P., Knobeloch K.P., Prinz M. (2015). Genetic targeting of microglia. Glia. 63:1–22.

Promotionsprojekte

Die Seite befindet sich im Aufbau. Inhalte folgen in Kürze.

Suche