Mechanotransduction mechanisms in vascular smooth muscle cells

Schubert, R., Lidington, D., Bolz, S. S. (2008). The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc.Res. 77, 8-18. Cardiovasc.Res.

 

We could demonstrate that PKA (Schubert et al., 1999), Rho-kinase (Schubert et al., 2002) and BK as well as Kv7 channels (Sausbier et al., 2005, Ma et al., 2020) contribute to the setting of the level of small artery myogenic tone. Of note, Kv7 channels are limited in their negative feedback on myogenic tone by BK channels and vice versa (Ma et al., 2020). In addition, it was demonstrated that the myogenic response is mediated by Rho-kinase (Schubert et al., 2002) and modulated by neuronal influences (Anschutz & Schubert, 2005). The mechanisms of the myogenic response have been discussed in 4 review articles (Schubert & Mulvany, 1999;Schubert & Brayden, 2005;Schubert et al., 2008;Lidington et al., 2013).

We have been participating in a cooperative study showing that endothelial TRPV4 channels are involved in flow-induced vessel dilations (Kohler et al., 2006).

 

References

 

Anschutz, S., Schubert, R. (2005) Modulation of the myogenic response by neurogenic influences in rat small arteries. Br J Pharmacol 146, 226-233

 

Kohler, R., Heyken, W. T., Heinau, P., Schubert, R., Si, H., Kacik, M., Busch, C., Grgic, I., Maier, T., Hoyer, J. (2006) Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol 26, 1495-1502

 

Lidington, D., Schubert, R., Bolz, S.S. (2013) Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. Cardiovasc Res 97, 404-12

 

Ma, D., Gaynullina, D. K., Schmidt, N., Mladenov, M., Schubert, R. (2020) The functional availability of arterial Kv7 channels is suppressed considerably by large-conductance calcium-activated potassium channels in 2- to 3-month old but not in 10- to 15-day old rats. Front Physiol 11, 597395

 

Sausbier, M., Arntz, C., Bucurenciu, I., Zhao, H., Zhou, X. B., Sausbier, U., Feil, S., Kamm, S., Essin, K., Sailer, C. A., Abdullah, U., Krippeit-Drews, P., Feil, R., Hofmann, F., Knaus, H. G., Kenyon, C., Shipston, M. J., Storm, J. F., Neuhuber, W., Korth, M., Schubert, R., Gollasch, M., Ruth, P. (2005) Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation 112, 60-68

 

Schubert, R. Brayden, J. E. (2005) Stretch-activated cation channels and the myogenic response of small arteries. In Mechanosensitivity in Cells and Tissues pp 402-417

 

Schubert, R., Kalentchuk, V. U., Krien, U. (2002) Rho kinase inhibition partly weakens myogenic reactivity in rat small arteries by changing calcium sensitivity. Am J Physiol Heart Circ Physiol 283, H2288-H2295

 

Schubert, R., Lehmann, G., Serebryakov, V. N., Mewes, H., Hopp, H. H. (1999) cAMP-dependent protein kinase is in an active state in rat small arteries possessing a myogenic tone. Am J Physiol 277, H1145-H1155

 

Schubert, R., Lidington, D., Bolz, S. S. (2008) The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res 77, 8-18

 

Schubert, R. Mulvany, M. J. (1999) The myogenic response: established facts and attractive hypotheses. Clin Sci 96, 313-326

 

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