Dr. Christoph Westerhausen

Arbeitsgruppenleiter "Biologische Physik"
Physiologie
Telefon: +49 821 598 - 3311
E-Mail:
Raum: 335 (R)
Adresse: Universitätsstraße 1 (Physik Nord), 86159 Augsburg

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Motivierte Studierende (Physik/Mawi/Medizin) gesucht für Abschlussarbeiten     JETZT !   

 

Du willst an unserem Projekt “Physical and functional interaction mechanisms at cell membranes and vessel walls“ mitwirken in Form einer/eines

  • Bachelorarbeit
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  • Projektarbeit
  • Laboraty Projects
  • Masterarbeit
  • Medizinischen Doktorarbeit?

Dann kontaktiere uns jetzt! => christoph.westerhausen@physik.uni-augsburg.de

Forschungsschwerpunkte

© Universität Augsburg
© Universität Augsburg
© Universität Augsburg
© Universität Augsburg
© Universität Augsburg

Cell manipulation, stimulation and sensing

• Acoustical stimulation of cell proliferation and migration
• Cell adhesion under flow
• Neural networks
• Acoustic Live Cell Sensing of wound healing, migration and adhesion

Thermodynamics of membranes and living systems

• Sound and shear enhanced drug uptake in cells
• Nanoparticle uptake in cells and lipid vesicles
• Correlation of membrane state and function (e.g. enzyme activity or uptake)

Cell-cell interaction

• Dynamics and stability of red blood cell aggregates (rosettes)
• Cell adhesion (endothelial cells, WBC, melanoma cells)

Technology and Biomaterials

• Wear resist and antibacterial diamond-like carbon surface modifications for implants
• Fast mixing at low Reynolds numbers for creation of therapeutic nanoparticles
• Acoustophotocatalysis - Employing SAW in heterogeneous catalysis

News

>> Research: Congratulations! Andrej´ s paper  “The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer" is accepted and will appear in Scientific Reports soon!

 

Key points:

 

  • the temperature dependence of the activity of ADAMTS13 when bound to a lipid bilayer shows a distinct maximum close to the main phase transition temperature Tm of the membrane
  • changing the carbon chain length of the used lipid, and thus Tm, shifts the activity maximum to the new Tm
  • comparing the activity at a constant temperature for three different membranes in the gel phase, the fluid phase and at the transition underline the role of the membrane state for the enzyme activity
  • these results are perfectly in line with the concept that increased fluctuations close to a phase transition are crucial for catalysis

 

>> Teaching: New elective starting next summer term: „Physiology in everyday life“    your idea/research question, your implementation, your answer!     

 

 

>> Award: We got the CeNS publication award 2021 in the category „Best Junior Scientist Publication“  for our paper  Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model, PNAS!

 

>> Research: Congratulations! Anna´´ s and Simon´ s paper  “Dynamic Effective Elasticity of Melanoma Cells under Shear and Elongational Flow Confirms Estimation from Force Spectroscopy” is accepted and will appeared in Biophysica.

 

article: https://www.mdpi.com/2673-4125/1/4/32/htm.

 

Key points:

 

  • The elasticity of A375 melanoma cells was determined by applying different methods: AFM + a cantilever with a pyramidal tip, AFM + tipless cantilevers and deformation analysis during passing a stenosis in a micro channe.l
  • We found higher and more widely distributed Young´´ s moduli E using a cantilever with a tip compared with the other methods due to local variations of E.
  • E scales with the logarithm of the loading rate.
  • The effective, overall elasticity indicates two population of the studied cell line.

 

>> Research: Congratulations!Nico´´ s paper  Broad lipid phase transitions in mammalian cell membranes measured by Laurdan fluorescence spectroscopy is accepted and will appear soon in BBA Biomembranes.

 

preprint: https://www.researchsquare.com/article/rs-515297/v1

 

article (proofreading pending): https://www.sciencedirect.com/science/article/abs/pii/S000527362100242X

 

Key points:

  • Membrane embedded Laurdan displays order disorder phase transitions even in frozen water
  • Cell membranes undergo order-disorder phase transitions as lipid vesicles but over a broader temperature range
  • As known for lipid vesicles order-disorder phase transitions in cell membranes are sensitive to cholesterol content, anaesthetic and pH
  • Order-disorder phase transitions in cell membranes are influenced by cell adaption processes, morphological changes and protein content

 

>> Research: Congratulations! Andrej´´`s and Felix´´ s paper  “Transient permeabilization of living cells combining shear flow and acoustic trapping for facilitated uptake of molecules” is accepted and will appeared soon in the Special Issue Developing Biophysical Tools in Processes.

 

https://www.mdpi.com/2227-9717/9/6/913/htm

 

Key points:

  • Molecular uptake under shear force @RT is a non-linear function of shear stress with a pronounced maximum, that could be related with a phase transition of the plasma membrane.
  • Acoustic trapping under flow increases the uptake up to a factor of 18.
  • This permeabilization method works for impermeable dyes, sugars and proteins.

 

>> Research: Congratulations! Sixuan´´`s paper  “Surface acoustic wave enhanced water splitting reaction with methanol as sacrifice material” is accepted and will appeared soon in Catalysis Science and Technology of the RSC.

 

https://pubs.rsc.org/en/content/articlelanding/2021/cy/d0cy01788d/unauth#!divAbstract

 

Key points:

  • SAW (Rayleigh waves) enhance water splitting using a Pt/TiO2 catalyst by more than +100%
  • The SAW accompanying electric field is crucial

 

>> Research: Our paper  “Shear-Horizontal Surface Acoustic Wave Sensor for Non-Invasive Monitoring of Dynamic Cell Spreading and Attachment in Wound Healing Assays” is accepted and will appear soon in Biosensors and Bioelectronics (Vol 173 (2021) 112807).

 

Download for free till Januar 8th 2021:  https://authors.elsevier.com/a/1c62U3PVtpkTxg

 

Key points:

  • Love waves allow for non-optical sensing of wound-healing-assays
  • Changes in cell adhesion strength influence the effective permittivity
  • Monitoring of culture conditions, like changes in osmolarity, is easily possible
  • Cell detachment kinetics can be measured quantitatively without microscopy

 

>> Research: Congratulations to our team, especially Manu, Kathi and Sophie! Our paper  “Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model” will appear soon  appeared in PNAS.

 

https://www.pnas.org/content/early/2020/11/25/2005203117

 

Key points:

  • SAW enhanced proliferation
  • SAW enhanced migration up to +135%
  • wave type is crucial (vertical substrate deflection)
  • effect conserved for various cell lines

 

>> Funding: Nicolas Färber just has been awarded with a Add-on Fellowship for Interdisciplinary Life Science 2020 of the Joachim-Herz-Stiftung! We congratulate Nico and thank the funders!

 

 

>> Research: We recently got funding for our collaboration project „Physikalische und funktionelle Mechanismen der Interaktionen an Zell- und Gefäßwänden“ (Physical and functional interaction mechanisms at cell membranes and vessel walls)

 

Collaborators:

  • Dr. Stefanie Grützner (Transfusionsmedizin und Hämostaseologie)
  • Dr. Torsten Gloe (Physiologie)
  • Prof. Dr. Udo Jeschke (Interdisziplinäres onkologisches Forschungslabor)
  • Prof. Dr. Achim Wixforth (Experimentalphysik I)
  • Prof. Dr. Julia Welzel (Klinik für Dermatologie und Allergologie)

https://www.uni-augsburg.de/de/fakultaet/med/forschung/forschungsfoerderung/gefoerderte-projekte/

 

> Research: Anna´’s paper  “Blood group and size dependent stability of P. falciparum infected red blood cell aggregates in capillaries” appeared in Biomicrofluidics! 

   >> paper: download here https://aip.scitation.org/doi/10.1063/1.5125038

 

>> Research: The summary on our successful ITN SAWTrain can be found online now!

 https://cordis.europa.eu/article/id/411685-a-novel-training-network-is-making-waves-with-tiny-quakes-on-chips

 

>> Research: Patta´´’s paper  “Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection”  just got accepted and will appeared soon in Scientific Reports! 

  >> paper: download here (open access) https://www.nature.com/articles/s41598-019-55110-0.pdf

 

>> Research: Sascha´´’s, Andrej´’s and Sven´’s paper  “Smart antimicrobial efficacy employing pH-sensitive ZnO-doped DLC coatings”   just got accepted and will appeared soon in Scientific Reports! 

   >> press release: read more https://www.uni-augsburg.de/de/campusleben/neuigkeiten/2019/11/21/1048/

   >> paper: download here (open access) https://www.nature.com/articles/s41598-019-53521-7.pdf

 

Publikationen

2021

Anna M. Jötten, Simon V. Neidinger, Julia K. Tietze, Julia Welzel, and Christoph Westerhausen

“Dynamic Effective Elasticity of Melanoma Cells under Shear and Elongational Flow Confirms Estimation from Force Spectroscopy“,

Biophysica, accepted 2021

 

Andrej Kamenac, Tobias Obser, Achim Wixforth, Matthias Schneider, and Christoph Westerhausen

“The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer”,

Scientific Reports, accepted 2021

 

Christoph Westerhausen
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2011

2022

Nicolas Färber und Christoph Westerhausen
Broad lipid phase transitions in mammalian cell membranes measured by Laurdan fluorescence spectroscopy

BibTeX | RIS | DOI

2021

Manuel S. Brugger, Lukas G. Schnitzler, Timo Nieberle, Achim Wixforth und Christoph Westerhausen
Shear-horizontal surface acoustic wave sensor for non-invasive monitoring of dynamic cell spreading and attachment in wound healing assays

BibTeX | RIS | DOI

Sixuan Wang, Rudolf Herrmann, Alexander Reiner, Achim Wixforth und Christoph Westerhausen
Surface acoustic wave enhanced water splitting reaction with methanol as a sacrificial material

PDF | BibTeX | RIS | DOI

Andrej Kamenac, Tobias Obser, Achim Wixforth, Matthias F. Schneider und Christoph Westerhausen
The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer

PDF | BibTeX | RIS | DOI

Andrej Kamenac, Felix L. Schilberth, Ernst Wagner, Achim Wixforth, Ulrich Lächelt und Christoph Westerhausen
Transient permeabilization of living cells: combining shear flow and acoustofluidic trapping for the facilitated uptake of molecules

PDF | BibTeX | RIS | DOI

2020

Anna Martina Jötten, Kirsten Moll, Mats Wahlgren, Achim Wixforth und Christoph Westerhausen
Blood group and size dependent stability of P. falciparum infected red blood cell aggregates in capillaries

PDF | BibTeX | RIS | DOI

Lukas Bergerhausen, Julius Grosche, Juliane Meißner, Christina Hecker, Michele F. Caliandro, Christoph Westerhausen, Andrej Kamenac, Maryam Rezaei, Matthias Mörgelin, Gereon Poschmann, Dietmar Vestweber, Eva-Maria Hanschmann und Johannes A. Eble
Extracellular redox regulation of α7β integrin-mediated cell migration is signaled via a dominant thiol-switch

PDF | BibTeX | RIS | DOI

U. Ratzel, O. Bayer, P. Bracht, Martin Hoffmann, Kai Jänke, Karl-Jürgen Kiesel, Clemens Mehnert, Christoph Scheck, Christoph Westerhausen, K.-G. Krapf, L. Herrmann und Janosch Blaul
Tieffrequente Geräusche und Infraschall von Windkraftanlagen und anderen Quellen: Bericht über Ergebnisse des Messprojekts 2013-2015

PDF | BibTeX | RIS | URL

Manuel S. Brugger, Kathrin Baumgartner, Sophie C. F. Mauritz, Stefan C. Gerlach, Florian Röder, Christine Schlosser, Regina Fluhrer, Achim Wixforth und Christoph Westerhausen
Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model

PDF | BibTeX | RIS | DOI

2019

Anna Martina Jötten, S. Angermann, Melanie E. M. Stamp, Dominik Breyer, Florian G. Strobl, Achim Wixforth und Christoph Westerhausen
Correlation of in vitro cell adhesion, local shear flow and cell density

PDF | BibTeX | RIS | DOI

Patrick W. Kudella, Katharina Preißinger, Matthias Morasch, Christina F. Dirscherl, Dieter Braun, Achim Wixforth und Christoph Westerhausen
Fission of lipid-vesicles by membrane phase transitions in thermal convection

PDF | BibTeX | RIS | DOI

Florian G. Strobl, D. M. Czubak, Achim Wixforth und Christoph Westerhausen
Ion controlled passive nanoparticle uptake in lipid vesicles in theory and experiment

PDF | BibTeX | RIS | DOI

Lukas G. Schnitzler, Stefanie Junger, Dominik M. Loy, Ernst Wagner, Achim Wixforth, Andreas Hörner, Ulrich Lächelt und Christoph Westerhausen
Size tunable nanoparticle formation employing droplet fusion by acoustic streaming applied to polyplexes

PDF | BibTeX | RIS | DOI

Sascha Buchegger, Andrej Kamenac, Sven Fuchs, Rudolf Herrmann, Pia Houdek, Christian Gorzelanny, Andreas Obermeier, Stephan Heller, Rainer Burgkart, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

PDF | BibTeX | RIS | DOI

Per Delsing, Andrew N. Cleland, Martin J. A. Schuetz, Johannes Knörzer, Géza Giedke, J. Ignacio Cirac, Kartik Srinivasan, Marcelo Wu, Krishna Coimbatore Balram, Christopher Bäuerle, Tristan Meunier, Christopher J. B. Ford, Paulo V. Santos, Edgar Cerda-Méndez, Hailin Wang, Hubert J. Krenner, Emeline D. S. Nysten, Matthias Weiß, Geoff R. Nash, Laura Thevenard, Catherine Gourdon, Pauline Rovillain, Max Marangolo, Jean-Yves Duquesne, Gerhard Fischerauer, Werner Ruile, Alexander Reiner, Ben Paschke, Dmytro Denysenko, Dirk Volkmer, Achim Wixforth, Henrik Bruus, Martin Wiklund, Julien Reboud, Jonathan M. Cooper, YongQing Fu, Manuel S. Brugger, Florian Rehfeldt und Christoph Westerhausen
The 2019 surface acoustic waves roadmap

PDF | BibTeX | RIS | DOI

2018

Melanie E. M. Stamp, Christoph Westerhausen, Wei Tong, Steven Prawer, David J. Garrett und Achim Wixforth
Acoustic streaming driven enhanced dye-uptake in cells for fluorescence imaging

PDF | BibTeX | RIS | DOI

Christoph G. Wittmann, Andrej Kamenac, Florian G. Strobl, Dietmar Czubak, Achim Wixforth und Christoph Westerhausen
Ionic strength and the supporting material strongly influence the adhesion of silica to supported lipid bilayers

PDF | BibTeX | RIS | DOI

Jochen Taiber, Sascha Buchegger, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
Optimizing lateral homogeneity of ion-induced surface modifications of non-planar dielectric polyethylene components employing ion fluence simulations and optical measurements of the sp2-dependent reflectivity

PDF | BibTeX | RIS | DOI

Manuel S. Brugger, Sarah Grundeen, Adele Doyle, Luke Theogarajan, Achim Wixforth und Christoph Westerhausen
Orchestrating cells on a chip: employing surface acoustic waves towards the formation of neural networks

PDF | BibTeX | RIS | DOI

2017

Andrej Kamenac, Achim Wixforth, T. Obser, S. Reinhard, M. F. Schneider und Christoph Westerhausen
Enzyme activity at lipid membranes - correlation of activity and membrane state [Abstract]

PDF | BibTeX | RIS | DOI

Mario Djukelic, Achim Wixforth und Christoph Westerhausen
Influence of neighboring adherent cells on laminar flow induced shear stress in vitro - a systematic study

PDF | BibTeX | RIS | DOI

Sascha Buchegger, Natascha Schuster, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
Multilayer diamond-like amorphous carbon coatings produced by ion irradiation of polymer films

PDF | BibTeX | RIS | DOI

Manuel S. Brugger, S. Grundeen, L. Theogarajan, Achim Wixforth und Christoph Westerhausen
Orchestrating cells on a chip employing standing surface acoustic waves towards neural networks [Abstract]

PDF | BibTeX | RIS | DOI

Anna Martina Jötten, T. Geislinger, K. Moll, M. Wahlgren, Achim Wixforth und Christoph Westerhausen
Red blood cell aggregates in malaria-the role of flow [Abstract]

PDF | BibTeX | RIS | DOI

2016

Patrick W. Kudella, Kirsten Moll, Mats Wahlgren, Achim Wixforth und Christoph Westerhausen
ARAM: an automated image analysis software to determine rosetting parameters and parasitaemia in Plasmodium samples

PDF | BibTeX | RIS | DOI

Melanie E. M. Stamp, Manuel S. Brugger, Achim Wixforth und Christoph Westerhausen
Acoustotaxis – in vitro stimulation in a wound healing assay employing surface acoustic waves

PDF | BibTeX | RIS | DOI

Sascha Buchegger, Caroline Vogel, Rudolf Herrmann, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials

PDF | BibTeX | RIS | DOI

Christoph Westerhausen, Lukas G. Schnitzler, Dominik Wendel, Rafał Krzysztoń, Ulrich Lächelt, Ernst Wagner, Joachim O. Rädler und Achim Wixforth
Controllable acoustic mixing of fluids in microchannels for the fabrication of therapeutic nanoparticles

PDF | BibTeX | RIS | DOI

Melanie E. M. Stamp, Anna Martina Jötten, Patrick W. Kudella, Dominik Breyer, Florian G. Strobl, Thomas M. Geislinger, Achim Wixforth und Christoph Westerhausen
Exploring the limits of cell adhesion under shear stress within physiological conditions and beyond on a chip

PDF | BibTeX | RIS | DOI

Melanie E. M. Stamp, Manuel S. Brugger, Achim Wixforth und Christoph Westerhausen
Manipulation of cell proliferation and migration employing surface acoustic waves and hydrophobic/hydrophilic structured substrates [Abstract]

PDF | BibTeX | RIS | DOI

U. Ratzel, L. Herrmann, Christoph Westerhausen, O. Bayer, K.-G. Krapf, M. Hoffmann, J. Blaul und C. Mehnert
Tieffrequente Geräusche (inkl. Infraschall) von Windkraftanlagen und anderen Quellen

BibTeX | RIS

2015

Melanie E. M. Stamp, Anna Martina Jötten, Dominik Breyer, Mario Djukelic, Florian G. Strobl, Patrick W. Kudella, A. Hartmann, Achim Wixforth und Christoph Westerhausen
A novel tool for in vitro correlation of cell adhesion behavior and local shear flow [Abstract]

PDF | BibTeX | RIS | DOI

Manuel S. Brugger, M. M. Stamp, Achim Wixforth und Christoph Westerhausen
Acoustotaxis - manipulation of cell proliferation and migration using surface acoustic waves [Abstract]

PDF | BibTeX | RIS | DOI

2014

Florian G. Strobl, Florian Seitz, Christoph Westerhausen, Armin Reller, Adriano A. Torrano, Christoph Bräuchle, Achim Wixforth und Matthias F. Schneider
Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

PDF | BibTeX | RIS | DOI

2012

Christoph Westerhausen, Florian G. Strobl, Rudolf Herrmann, A. T. Bauer, S. W. Schneider, Armin Reller, Achim Wixforth und Matthias F. Schneider
Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment

PDF | BibTeX | RIS | DOI

Christoph Westerhausen
On the role of soft interfaces for the understanding of blood clotting

PDF | BibTeX | RIS

2011

Stephan Niland, Christoph Westerhausen, Stefan W. Schneider, Beate Eckes, Matthias F. Schneider und Johannes A. Eble
Biofunctionalization of a generic collagenous triple helix with the α2β1 integrin binding site allows molecular force measurements

BibTeX | RIS | DOI

Alexander T. Bauer, Elwira A. Strozyk, Christian Gorzelanny, Christoph Westerhausen, Anna Desch, Matthias F. Schneider und Stefan W. Schneider
Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells

BibTeX | RIS | DOI

A. Bauer, E. Strozyk, C. Gorzelanny, Christoph Westerhausen, A. Desch, M. F. Schneider und S. W. Schneider
Silica nanoparticles-induced necrosis and exocytosis of von Willebrand factor in primary human endothelial cells is surface area-dependent [Abstract]

PDF | BibTeX | RIS | DOI

Lebenslauf

 

Mehr Publikationen und früherer Blog der Biophysik Gruppe (Stand Februar 2020, Link)

 

 

Vita

 

since 2019: Research group leader "Biophysics Group", Medizinsche Fakultät, Lehrstuhl für Physiologie, University of Augsburg

2018: Research stay at the Karolinska Institute in Stockholm

2014 - 2019: Research group leader, Institute of Physics, Experimentalphysik 1, University of Augsburg

2012 – 2015: Project manager at Wölfel Beratende Ingenieure, Würzburg

2012: Dissertation „On the role of soft interfaces for the understanding of blood clotting”

2011: Research period at Boston University

2009 – 2012: University of Augsburg & University Hospital Mannheim

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