Dr. Christoph Westerhausen
| Telefon: | +49 821 598 - 3311 |
| E-Mail: | |
| Raum: | 335 (R) |
| Adresse: | Universitätsstraße 1 (Physik Nord), 86159 Augsburg |
Forschungsschwerpunkte
Cell manipulation, stimulation and sensing
• Acoustical stimulation of cell proliferation and migration
• Cell adhesion under flow
• Neural networks
• Acoustic Live Cell Sensing of wound healing, migration and adhesion
Thermodynamics of membranes and living systems
• Sound and shear enhanced drug uptake in cells
• Nanoparticle uptake in cells and lipid vesicles
• Correlation of membrane state and enzyme activity
Cell-cell interaction
• Dynamics and stability of red blood cell aggregates (rosettes)
• Cell adhesion (endothelial cells, WBC, melanoma cells)
Technology and Biomaterials
• Wear resist and antibacterial diamond-like carbon surface modifications for implants
• Fast mixing at low Reynolds numbers for creation of therapeutic nanoparticles
• Acoustophotocatalysis - Employing SAW in heterogeneous catalysis
News
>> Research: Congratulations! Sixuan´´`s paper “Surface acoustic wave enhanced water splitting reaction with methanol as sacrifice material” is accepted and will appear soon in Catalysis Science and Technology of the RSC.
Key points:
- SAW (Rayleigh waves) enhance water splitting using a Pt/TiO2 catalyst by more than +100%
- The SAW accompanying electric field is crucial
>> Research: Our paper “Shear-Horizontal Surface Acoustic Wave Sensor for Non-Invasive Monitoring of Dynamic Cell Spreading and Attachment in Wound Healing Assays” is accepted and will appear soon in Biosensors and Bioelectronics (Vol 173 (2021) 112807).
Download for free till Januar 8th 2021: https://authors.elsevier.com/a/1c62U3PVtpkTxg
Key points:
- Love waves allow for non-optical sensing of wound-healing-assays
- Changes in cell adhesion strength influence the effective permittivity
- Monitoring of culture conditions, like changes in osmolarity, is easily possible
- Cell detachment kinetics can be measured quantitatively without microscopy
>> Research: Congratulations to our team, especially Manu, Kathi and Sophie! Our paper “Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model” will appear soon appeared in PNAS.
https://www.pnas.org/content/early/2020/11/25/2005203117
Key points:
- SAW enhanced proliferation
- SAW enhanced migration up to +135%
- wave type is crucial (vertical substrate deflection)
- effect conserved for various cell lines
>> Funding: Nicolas Färber just has been awarded with a Add-on Fellowship for Interdisciplinary Life Science 2020 of the Joachim-Herz-Stiftung! We congratulate Nico and thank the funders!
>> Research: We recently got funding for our collaboration project „Physikalische und funktionelle Mechanismen der Interaktionen an Zell- und Gefäßwänden“ (Physical and functional interaction mechanisms at cell membranes and vessel walls)
Collaborators:
- Dr. Stefanie Grützner (Transfusionsmedizin und Hämostaseologie)
- Dr. Torsten Gloe (Physiologie)
- Prof. Dr. Udo Jeschke (Interdisziplinäres onkologisches Forschungslabor)
- Prof. Dr. Achim Wixforth (Experimentalphysik I)
- Prof. Dr. Julia Welzel (Klinik für Dermatologie und Allergologie)
https://www.uni-augsburg.de/de/fakultaet/med/forschung/forschungsfoerderung/gefoerderte-projekte/
> Research: Anna´’s paper “Blood group and size dependent stability of P. falciparum infected red blood cell aggregates in capillaries” appeared in Biomicrofluidics!
>> paper: download here https://aip.scitation.org/doi/10.1063/1.5125038
>> Research: The summary on our successful ITN SAWTrain can be found online now!
>> Research: Patta´´’s paper “Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection” just got accepted and will appeared soon in Scientific Reports!
>> paper: download here (open access) https://www.nature.com/articles/s41598-019-55110-0.pdf
>> Research: Sascha´´’s, Andrej´’s and Sven´’s paper “Smart antimicrobial efficacy employing pH-sensitive ZnO-doped DLC coatings” just got accepted and will appeared soon in Scientific Reports!
>> press release: read more https://www.uni-augsburg.de/de/campusleben/neuigkeiten/2019/11/21/1048/
>> paper: download here (open access) https://www.nature.com/articles/s41598-019-53521-7.pdf
Publikationen
2021
Manuel S. Brugger, Lukas G. Schnitzler, Timo Nieberle, Achim Wixforth, and Christoph Westerhausen
“Shear-Horizontal Surface Acoustic Wave Sensor for Non-Invasive Monitoring of Dynamic Cell Spreading and Attachment in Wound Healing Assays”
Biosensors and Bioelectronics, accepted 2020, Vol. 173 (2021) 112807
Sixuan Wang, Rudolf Herrmann, Alexander Reiner, Achim Wixforth, and Christoph Westerhausen
„Surface acoustic wave enhanced water splitting reaction with methanol as sacrifice material“
RSC Catalysis Science and Technology, accepted, 2020
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2020 |
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Anna Martina Jötten, Kirsten Moll, Mats Wahlgren, Achim Wixforth und Christoph Westerhausen
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Lukas Bergerhausen, Julius Grosche, Juliane Meißner, Christina Hecker, Michele F. Caliandro, Christoph Westerhausen, Andrej Kamenac, Maryam Rezaei, Matthias Mörgelin, Gereon Poschmann, Dietmar Vestweber, Eva-Maria Hanschmann und Johannes A. Eble
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U. Ratzel, O. Bayer, P. Bracht, Martin Hoffmann, Kai Jänke, Karl-Jürgen Kiesel, Clemens Mehnert, Christoph Scheck, Christoph Westerhausen, K.-G. Krapf, L. Herrmann und Janosch Blaul
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Manuel S. Brugger, Kathrin Baumgartner, Sophie C. F. Mauritz, Stefan C. Gerlach, Florian Röder, Christine Schlosser, Regina Fluhrer, Achim Wixforth und Christoph Westerhausen
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2019 |
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A. M. Jötten, S. Angermann, M. E. M. Stamp, D. Breyer, Florian G. Strobl, Achim Wixforth und Christoph Westerhausen
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Patrick W. Kudella, Katharina Preißinger, Matthias Morasch, Christina F. Dirscherl, Dieter Braun, Achim Wixforth und Christoph Westerhausen
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Florian G. Strobl, D. M. Czubak, Achim Wixforth und Christoph Westerhausen
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Lukas G Schnitzler, Stefanie Junger, Dominik M Loy, Ernst Wagner, Achim Wixforth, Andreas Hörner, Ulrich Lächelt und Christoph Westerhausen
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Sascha Buchegger, Andrej Kamenac, Sven Fuchs, Rudolf Herrmann, Pia Houdek, Christian Gorzelanny, Andreas Obermeier, Stephan Heller, Rainer Burgkart, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
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Per Delsing, Andrew N. Cleland, Martin J. A. Schuetz, Johannes Knörzer, Géza Giedke, J. Ignacio Cirac, Kartik Srinivasan, Marcelo Wu, Krishna Coimbatore Balram, Christopher Bäuerle, Tristan Meunier, Christopher J. B. Ford, Paulo V. Santos, Edgar Cerda-Méndez, Hailin Wang, Hubert J. Krenner, Emeline D. S. Nysten, Matthias Weiß, Geoff R. Nash, Laura Thevenard, Catherine Gourdon, Pauline Rovillain, Max Marangolo, Jean-Yves Duquesne, Gerhard Fischerauer, Werner Ruile, Alexander Reiner, Ben Paschke, Dmytro Denysenko, Dirk Volkmer, Achim Wixforth, Henrik Bruus, Martin Wiklund, Julien Reboud, Jonathan M. Cooper, YongQing Fu, Manuel S. Brugger, Florian Rehfeldt und Christoph Westerhausen
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2018 |
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Christoph G. Wittmann, Andrej Kamenac, Florian G. Strobl, Dietmar Czubak, Achim Wixforth und Christoph Westerhausen
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Jochen Taiber, Sascha Buchegger, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
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Manuel S. Brugger, Sarah Grundeen, Adele Doyle, Luke Theogarajan, Achim Wixforth und Christoph Westerhausen
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2017 |
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Mario Djukelic, Achim Wixforth und Christoph Westerhausen
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Sascha Buchegger, Natascha Schuster, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
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2016 |
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Patrick W. Kudella, Kirsten Moll, Mats Wahlgren, Achim Wixforth und Christoph Westerhausen
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Melanie E. M. Stamp, Manuel S. Brugger, Achim Wixforth und Christoph Westerhausen
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Sascha Buchegger, Caroline Vogel, Rudolf Herrmann, Bernd Stritzker, Achim Wixforth und Christoph Westerhausen
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Christoph Westerhausen, Lukas G. Schnitzler, Dominik Wendel, Rafał Krzysztoń, Ulrich Lächelt, Ernst Wagner, Joachim O. Rädler und Achim Wixforth
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Melanie E. M. Stamp, Anna M. Jötten, Patrick W. Kudella, Dominik Breyer, Florian G. Strobl, Thomas M. Geislinger, Achim Wixforth und Christoph Westerhausen
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Melanie E. M. Stamp, Manuel S. Brugger, Achim Wixforth und Christoph Westerhausen
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U. Ratzel, L. Herrmann, Christoph Westerhausen, O. Bayer, K.-G. Krapf, M. Hoffmann, J. Blaul und C. Mehnert
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2014 |
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Florian G. Strobl, Florian Seitz, Christoph Westerhausen, Armin Reller, Adriano A. Torrano, Christoph Bräuchle, Achim Wixforth und Matthias F. Schneider
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Florian G. Strobl, Florian Seitz, Christoph Westerhausen, Armin Reller, Adriano A. Torrano, Christoph Bräuchle, Achim Wixforth und Matthias F. Schneider
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2012 |
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Christoph Westerhausen, Florian G. Strobl, Rudolf Herrmann, A. T. Bauer, S. W. Schneider, Armin Reller, Achim Wixforth und Matthias F. Schneider
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Christoph Westerhausen
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2011 |
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Stephan Niland, Christoph Westerhausen, Stefan W. Schneider, Beate Eckes, Matthias F. Schneider und Johannes A. Eble
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Alexander T. Bauer, Elwira A. Strozyk, Christian Gorzelanny, Christoph Westerhausen, Anna Desch, Matthias F. Schneider und Stefan W. Schneider
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Lebenslauf
Mehr Publikationen und früherer Blog der Biophysik Gruppe (Stand Februar 2020, Link)
Vita
since 2019: Research group leader "Biophysics Group", Medizinsche Fakultät, Lehrstuhl für Physiologie, University of Augsburg
2018: Research stay at the Karolinska Institute in Stockholm
2014 - 2019: Research group leader, Institute of Physics, Experimentalphysik 1, University of Augsburg
2012 – 2015: Project manager at Wölfel Beratende Ingenieure, Würzburg
2012: Dissertation „On the role of soft interfaces for the understanding of blood clotting”
2011: Research period at Boston University
2009 – 2012: University of Augsburg & University Hospital Mannheim