BKH Augsburg
BKH Augsburg


Our research interest focuses on the early detection of neurodegenerative diseases as well as their differentiated classification via innovative imaging diagnostic techniques. Furthermore, we investigate the influence on neurodegenerative diseases through transcranial brain stimulation methods, e.g. transcranial magnetic or direct current stimulation. Another research interest is devoted to the relatives of patients living with dementia and their affection by the diseases, also taking into account the special circumstances during the Corona pandemic. Furthermore, we aspire to better understand the relatives' sense of dignity as well as to implement and evaluate specific (group) therapeutic offers for relevant target groups.


GeKo (memory cohort of the University of Augsburg)

In this open cross-sectional and longitudinal study, a dementia cohort will be established for a discriminating evaluation of clinical symptoms related to their final diagnosis as well as for examinations at annual intervals over 3 consecutive years. With the gained knowledge, we strive to improve the early detection of neurodegenerative diseases. For this, we are looking for patients with dementia in both, early and advanced, stages.


Repetitive transcranial magnetic stimulation (rTMS) in corticobasal syndrome (CBS)

This is a funded project of the Medical Faculty of the University of Augsburg. In the pathophysiologically oriented study, differences in the cortical GABA level between patients with CBS and healthy participants are identified cross-sectionally. Furter, therapeutic potential of rTMS in patients with CBS is examined based on intervention. For this, we are looking for healthy participants as well as patients diagnosed with corticobasal syndrome.


  1. Häckert J, Falkai P, Perneczky R, Pogarell O. Der sprachlose Patient. MMW Fortschr Med. 2018 Sep; 160(15): 53-56. DOI: 10.1007/s15006-018-0888-z

  2. Hasan A, Häckert J, Strube W. Nicht-dopaminerge Antipsychotika: Hintergründe und neue Substanzen. Info Neurologie & Psychiatrie. Apr 2021. DOI: 10.1007/s15005-021-1901-0.

  3. Wiese E, Häckert J. Würde und Demenz. Info Neurologie & Psychiatrie. 2022; 24(11).

  1. Haeckert J, Lasser C, Pross B, Hasan A, Strube W. Comparative study of motor cortical excitability changes following anodal tDCS or high-frequency tRNS in relation to stimulation duration. Physiol Rep. 2020 Oct;8(19):e14595. doi: 10.14814/phy2.14595. PMID: 32996722; PMCID: PMC7525483.

  2. Haeckert J, Brendel M, Beyer L, Barthel H, Sabri O, Hasan A, Perneczky R. Effective Valproic Acid Treatment in a Patient With Delusional Parasitosis Due to Corticobasal Syndrome and Alzheimer Disease. J Clin Psychopharmacol. 2021 May-Jun 01;41(3):335-337. doi: 10.1097/JCP.0000000000001378. PMID: 33734170.

  3. Haeckert J, Rothwell J, Hannah R, Hasan A, Strube W. Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers. Brain Sci. 2021 Jun 1;11(6):737. doi: 10.3390/brainsci11060737. PMID: 34205963; PMCID: PMC8230207.

  4. Palleis C, Brendel M, Finze A, Weidinger E, Bötzel K, Danek A, Beyer L, Nitschmann A, Kern M, Biechele G, Rauchmann BS, Häckert J, Höllerhage M, Stephens AW, Drzezga A, van Eimeren T, Villemagne VL, Schildan A, Barthel H, Patt M, Sabri O; German Imaging Initiative for Tauopathies (GII4T), Bartenstein P, Perneczky R, Haass C, Levin J, Höglinger GU. Cortical [18 F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes. Mov Disord. 2021 Sep;36(9):2104-2115. doi: 10.1002/mds.28624. Epub 2021 May 5. PMID: 33951244.

  5. Biechele G, Rauchmann B-S, Janowitz D, Buerger K, Franzmeier N, Weidinger E, Guersel S, Schuster S, Finze A, Harris S, Schmitt J, Beyer L, Lindner S, Unterrainer M, Eckenweber F, Albert N, Wetzel C, Rupprecht R, Rominger A, Palleis C, Katzdobler S, Danek A, Burow L, Kurz C, Zaganjori M, Trappmann L-K, Goldhardt O, Grimmer T, Haeckert J, et al. Associations between sex, body mass index, and the individual microglial response in Alzheimer’s disease. Alzheimer's & dementia. 31 Dec 2021 DOI: 10.1002/alz.052772.

  6. Sabrina Katzdobler, Alexander Nitschmann, Henryk Barthel, Gerard Bischof, Leonie Beyer, Ken Marek, Mengmeng Song, Olivia Wagemann, Carla Palleis, Anne Nack, Urban Fietzek, Carolin Kurz, Jan Häckert, et al. Additive value of [18F]PI-2620 perfusion imaging in four-repeat tauopathies. European Journal of Nuclear Medicine and Molecular Imaging. 2022. DOI: 10.21203/rs.3.rs-1269572/v1.

  7. Ersin Ersözlü, Julia Utecht, Robert Perneczky, Maia Tatò, Carolin Kurz, Jan Haeckert, et al. A residual marker of cognitive reserve is associated with resting-state intrinsic functional connectivity along the Alzheimer’s disease continuum. Journal of Alzheimers Disease. 2022. Preprint. DOI: 10.1101/2022.01.17.22269026

  8. Boris-Stephan Rauchmann, Matthias Brendel, Nicolai Franzmeier, Lena Trappmann, Mirlind Zaganjori, Estrella Morenas-Rodriguez, Selim Guersel, Lena Burow, Carolin Kurz, Jan Haeckert, et al. MRI connectivity-based spread of microglial activation in early Alzheimer's disease. Annals of Neurology. Aug 2022 DOI: 10.1002/ana.26465

  9. Mezger E, Brunoni AR, Hasan A, Häckert J, Strube W, et al. tDCS for Auditory Verbal Hallucinations in a Case of Schizophrenia and Left Frontal Lesion: Efield Simulation and Clinical Results. Neurocase. 2020 Jun 12; 1-7. DOI: 10.1080/13554794.2020.1776334

  10. Campana M, Wagner E, Wobrock T, Langguth B, Landgrebe M, Eichhammer P, Frank E, Cordes J, Wölwer W, Winterer G, Gaebel W, Hajak G, Ohmann C, Verde PE, Rietschel M, Malchow B, Ahmed R, Strube W, Häckert J, Schneider-Axmann T, Falkai P, Hasan A. Effects of high-frequency prefrontal rTMS on heart frequency rates and blood pressure in schizophrenia. Journal of Psychiatric Research. June 2021. DOI: 10.1016/j.jpsychires.2021.06.010

  11. Roeh A, Holdenrieder S, Schoenfeld J, Häckert J, Halle M, Falkai P, Scherr J, Hasan A. Decreased serum BDNF levels following marathon running. Frontiers in Physiology. DOI: 10.3389/fphys.2021.668454.

  12. Pross B, Strube W, Papazova I, Güler D, Häckert J, Keeser D, Padberg F, Siamouli M, Falkai P, Hasan A. Anodal tDCS sustainably increases alpha activity in patients with schizophrenia. Neuropsychopharmacology Reports. 2022-06-18. DOI: 10.1002/npr2.12274