Publications
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2023 |
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Johann Frei and Frank Kramer. 2023. German medical named entity recognition model and data set creation using machine translation and word alignment: algorithm development and validation. JMIR Formative Research 7, e39077. DOI: 10.2196/39077 |
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Dominik Mueller, Silvan Mertes, Niklas Schroeter, Fabio Hellmann, Miriam Elia, Bernhard Bauer, Wolfgang Reif, Elisabeth André and Frank Kramer. 2023. Towards automated COVID-19 presence and severity classification. In Maria Hägglund, Madeleine Blusi, Stefano Bonacina, Lina Nilsson, Inge Cort Madsen, Sylvia Pelayo, Anne Moen, Arriel Benis, Lars Lindsköld and Parisis Gallos (Ed.). Caring is sharing – exploiting the value in data for health and innovation. IOS Press, Amsterdam (Studies in Health Technology and Informatics ; 302), 917-921. DOI: 10.3233/shti230309 |
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2022 |
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Florian Auer, Zhibek Abdykalykova, Dominik Müller and Frank Kramer. 2022. Adaptation of HL7 FHIR for the exchange of patients’ gene expression profiles. In John Mantas, Parisis Gallos, Emmanouil Zoulias, Arie Hasman, Mowafa S. Househ, Mowafa S. Househ, Marianna Diomidous, Joseph Liaskos and Martha Charalampidou (Ed.). Advances in informatics, management and technology in healthcare. IOS Press (Studies in Health Technology and Informatics ; 295), 332-335. DOI: 10.3233/shti220730 |
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Dominik Müller, Inaki Soto-Rey and Frank Kramer. 2022. An analysis on ensemble learning optimized medical image classification with deep convolutional neural networks. IEEE Access 10, 66467-66480. DOI: 10.1109/access.2022.3182399 |
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Dominik Fuchs, Ann-Kathrin Waibel, Maximilian Karthan, Nadine Seifert, Michael Örtl, Sabrina Bethge, Gina Fischer, Luca Waschbüsch, Steffen Netzband, Frank Kramer, Andreas Mahler, Alexandra Teynor, Dominik Merli, Elisabeth Veronica Mess, Jennifer Öttinger, Stefanie Schmid, Amelie Scheu, Walter Swoboda and Petra Friedrich. 2022. CARE REGIO – digital transformation and technology in nursing care. In John Mantas, Arie Hasman, Mowafa S. Househ, Parisis Gallos, Emmanouil Zoulias and Joseph Liaskos (Ed.). Informatics and Technology in Clinical Care and Public Health. IOS Press (Studies in Health Technology and Informatics ; 289), 286-289. DOI: 10.3233/shti210915 |
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Florian Auer, Simone Mayer and Frank Kramer. 2022. Data-dependent visualization of biological networks in the web-browser with NDExEdit. PLOS Computational Biology 18, 6, 1010205. DOI: 10.1371/journal.pcbi.1010205 |
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Johann Frei, Iñaki Soto-Rey and Frank Kramer. 2022. DrNote: an open medical annotation service. PLOS Digital Health 1, 8, e0000086. DOI: 10.1371/journal.pdig.0000086 |
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Johann Frei and Frank Kramer. 2022. GERNERMED: an open German medical NER model. Software Impacts 11, 100212. DOI: 10.1016/j.simpa.2021.100212 |
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Seyed-Ahmad Ahmadi, Johann Frei, Gerome Vivar, Marianne Dieterich and Valerie Kirsch. 2022. IE-Vnet: deep learning-based segmentation of the inner ear's total fluid space. Frontiers in Neurology 13, 663200. DOI: 10.3389/fneur.2022.663200 |
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Florian Auer, Zhibek Abdykalykova, Dominik Müller and Frank Kramer. 2022. Implementation of gene expression profiles in the HL7 FHIR standard. In Brigitte Séroussi, Patrick Weber, Ferdinand Dhombres, Cyril Grouin, Jan-David Liebe, Sylvia Pelayo, Andrea Pinna, Bastien Rance, Lucia Sacchi, Adrien Ugon, Arriel Benis and Parisis Gallos (Ed.). Challenges of Trustable AI and Added-Value on Health. IOS Press (Studies in Health Technology and Informatics ; 294), 417-418. DOI: 10.3233/shti220490 |
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Dominik Müller, Dennis Hartmann, Philip Meyer, Florian Auer, Iñaki Soto-Rey and Frank Kramer. 2022. MISeval: a metric library for medical image segmentation evaluation. In Brigitte Séroussi, Patrick Weber, Ferdinand Dhombres, Cyril Grouin, Jan-David Liebe, Sylvia Pelayo, Andrea Pinna, Bastien Rance, Lucia Sacchi, Adrien Ugon, Arriel Benis and Parisis Gallos (Ed.). Challenges of Trustable AI and Added-Value on Health. IOS Press (Studies in Health Technology and Informatics ; 294), 33-37. DOI: 10.3233/shti220391 |
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Florian Auer, Johann Frei, Dominik Müller and Frank Kramer. 2022. Perspective on code submission and automated evaluation platforms for university teaching. In Paula Otero, Philip Scott, Susan Z. Martin and Elaine Huesing (Ed.). MEDINFO 2021: One world, one health – global partnership for digital innovation. IOS Press (Studies in Health Technology and Informatics ; 290), 912-916. DOI: 10.3233/shti220212 |
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Dominik Müller, Iñaki Soto-Rey and Frank Kramer. 2022. Towards a guideline for evaluation metrics in medical image segmentation. BMC Research Notes 15, 1, 210. DOI: 10.1186/s13104-022-06096-y |
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2021 |
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Manuel Manfred Nietert, Liza Vinhoven, Florian Auer, Sylvia Hafkemeyer and Frauke Stanke. 2021. Comprehensive analysis of chemical structures that have been tested as CFTR activating substances in a publicly available database CandActCFTR. Frontiers in Pharmacology 12, 689205. DOI: 10.3389/fphar.2021.689205 |
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Hryhorii Chereda, Annalen Bleckmann, Kerstin Menck, Júlia Perera-Bel, Philip Stegmaier, Florian Auer, Frank Kramer, Andreas Leha and Tim Beißbarth. 2021. Explaining decisions of graph convolutional neural networks: patient-specific molecular subnetworks responsible for metastasis prediction in breast cancer. Genome Medicine 13, 1, 42. DOI: 10.1186/s13073-021-00845-7 |
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Dominik Müller and Frank Kramer. 2021. MIScnn: a framework for medical image segmentation with convolutional neural networks and deep learning. BMC Medical Imaging 21, 1, 12. DOI: 10.1186/s12880-020-00543-7 |
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Dominik Müller, Iñaki Soto-Rey and Frank Kramer. 2021. Multi-disease detection in retinal imaging based on ensembling heterogeneous deep learning models. In Rainer Röhrig, Tim Beißbarth, Jochem König, Claudia Ose, Geraldine Rauch, Ulrich Sax, Björn Schreiweis and Martin Sedlmayr (Ed.). German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal. IOS Press (Studies in Health Technology and Informatics ; 283), 23-31. DOI: 10.3233/shti210537 |
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J. Eduardo Martinez-Hernandez, Zaynab Hammoud, Alessandra Mara de Sousa, Frank Kramer, Rubens L. do Monte-Neto, Vinicius Maracaja-Coutinho and Alberto J. M. Martin. 2021. Network-based approaches reveal potential therapeutic targets for host-directed antileishmanial therapy driving drug repurposing. Microbiology Spectrum 9, 2, e01018-21. DOI: 10.1128/spectrum.01018-21 |
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M. Storck, S. Sandmann, P. Bruland, M. P. Pereira, S. Steinke, C. Riepe, Iñaki Soto‐Rey, S. Garcovich, M. Augustin, C. Blome, S. Bobko, F. J. Legat, N. Potekaev, A. Lvov, L. Misery, W. Weger, A. Reich, E. Şavk, M. Streit, E. Serra‐Baldrich, J. C. Szepietowski, M. Dugas, S. Ständer and C. Zeidler. 2021. Pruritus intensity scales across Europe: a prospective validation study. Journal of the European Academy of Dermatology and Venereology 35, 5, 1176-1185. DOI: 10.1111/jdv.17111 |
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2020 |
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Frank Kramer, Wolfgang Reif, Matthias Schmidt, Thomas Schneider, Karin Thieme and Theo Ungerer. 2020. Die Fakultät für Angewandte Informatik: partnerschaftliche Lösungen für globale Herausforderungen. In Hubert Zapf (Ed.). Wissenschaft, Kreativität, Verantwortung - 50 Jahre Universität Augsburg. Schnell & Steiner, Regensburg, 182-199. |
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Michael Örtl, Felix Holl, Marina Fotteler, Frank Kramer, Andreas Mahler, Dominik Merli, Elisabeth Veronica Mess, Stefanie Schmid, Alexandra Teynor, Petra Friedrich and Walter Swoboda. 2020. Digitalizing nursing in the Bavarian Swabia region of Germany: presentation of the joint project CARE REGIO. Studies in Health Technology and Informatics 272, 265-266. DOI: 10.3233/shti200545 |
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Zaynab Hammoud and Frank Kramer. 2020. Multipath: an R package to generate integrated reproducible pathway models. Biology 9, 12, 483. DOI: 10.3390/biology9120483 |
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2019 |
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Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz and Steven A. Johnsen. 2019. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. Clinical Epigenetics 11, 1, 4. DOI: 10.1186/s13148-018-0601-1 |
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2018 |
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Chaudhry M. S. Sarwar, Muthiah Vaduganathan, Stefan D. Anker, Stefano Coiro, Lampros Papadimitriou, Joel Saltz, Elinor R. Schoenfeld, Richard L. Clark, Wilfried Dinh, Frank Kramer, Mihai Gheorghiade, Gregg C. Fonarow and Javed Butler. 2018. Mobile health applications in cardiovascular research. International Journal of Cardiology 269, 265-271. DOI: 10.1016/j.ijcard.2018.06.039 |
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Zaynab Hammoud and Frank Kramer. 2018. mully: an R package to create, modify and visualize multilayered graphs. Genes 9, 11, 519. DOI: 10.3390/genes9110519 |
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2017 |
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Michael Coll Barroso, Philip Boehme, Frank Kramer, Thomas Mondritzki, Till Koehler, Jan-Erik Gülker, Martin Karoff and Wilfried Dinh. 2017. Endostatin a Potential Biomarker for Heart Failure with Preserved Ejection Fraction. Arquivos Brasileiros de Cardiologia 109, 5, 448-456. DOI: 10.5935/abc.20170144 |
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Frank Kramer, Hani N. Sabbah, James J. Januzzi, Faiez Zannad, J. Peter van Tintelen, Erik B. Schelbert, Raymond J. Kim, Hendrik Milting, Richardus Vonk, Brien Neudeck, Richard Clark, Klaus Witte, Wilfried Dinh, Burkert Pieske, Javed Butler and Mihai Gheorghiade. 2017. Redefining the role of biomarkers in heart failure trials: expert consensus document. Heart Failure Reviews 22, 3, 263-277. DOI: 10.1007/s10741-017-9608-5 |
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2016 |
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Frank Kramer and Wilfried Dinh. 2016. ChemInform Abstract: Molecular and Digital Biomarker Supported Decision Making in Clinical Studies in Cardiovascular Indications [Review]. ChemInform 47, 30. DOI: 10.1002/chin.201630287 |
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Mihai Gheorghiade, Christopher J. Larson, Sanjiv J. Shah, Stephen J. Greene, John G.F. Cleland, Wilson S. Colucci, Preston Dunnmon, Stephen E. Epstein, Raymond J. Kim, Ramin V. Parsey, Norman Stockbridge, James Carr, Wilfried Dinh, Thomas Krahn, Frank Kramer, Karin Wahlander, Lawrence I. Deckelbaum, David Crandall, Shunichiro Okada, Michele Senni, Sergey Sikora, Hani N. Sabbah and Javed Butler. 2016. Developing New Treatments for Heart Failure: Focus on the Heart. Circulation: Heart Failure 9, 5. DOI: 10.1161/circheartfailure.115.002727 |
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Javed Butler, Carine E. Hamo, James E. Udelson, Bertram Pitt, Clyde Yancy, Sanjiv J. Shah, Patrice Desvigne-Nickens, Harold S. Bernstein, Richard L. Clark, Christophe Depre, Wilfried Dinh, Andrew Hamer, Patricia Kay-Mugford, Frank Kramer, Martin Lefkowitz, Kelly Lewis, Juan Maya, Simon Maybaum, Mahesh J. Patel, Pia S. Pollack, Lothar Roessig, Sarit Rotman, Afshin Salsali, J. Jason Sims, Michele Senni, Giuseppe Rosano, Preston Dunnmon, Norman Stockbridge, Stefan D. Anker, Michael R. Zile and Mihai Gheorghiade. 2016. Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction. Circulation: Heart Failure 9, 11. DOI: 10.1161/circheartfailure.116.003358 |
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Frank Kramer and Wilfried Dinh. 2016. Molecular and Digital Biomarker Supported Decision Making in Clinical Studies in Cardiovascular Indications. Archiv der Pharmazie 349, 6, 399-409. DOI: 10.1002/ardp.201600055 |
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Michael Coll Barroso, Frank Kramer, Stephen J. Greene, Daniel Scheyer, Till Köhler, Martin Karoff, Melchior Seyfarth, Mihai Gheorghiade and Wilfried Dinh. 2016. Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction. BMC Cardiovascular Disorders 16, 1, 199. DOI: 10.1186/s12872-016-0376-2 |
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2014 |
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Frank Kramer and Hendrik Milting. 2014. Galectin-3 in cardiovascular disease. In Victor R. Preedy and Vinood B. Patel (Ed.). General methods in biomarker research and their applications. Springer, Dordrecht, 1-17. DOI: 10.1007/978-94-007-7740-8_32-1 |
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I. Blanta, Frank Kramer, T. Krahn, H. Frank, C. Kropf-Sanchen, K. M. Schumann-Stoiber, S. Rüdiger, D. Gagiannis, W. Rottbauer and Christina Schumann. 2014. Machbarkeit und Sicherheit der sequenziellen Re-Biopsie mittels Bronchoskopie beim Lungenkarzinom – erste Daten aus der BIO-GEN-SIG-ULM Studie. Pneumologie 68, S01, V554. DOI: 10.1055/s-0034-1367775 |
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2013 |
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Frank Kramer. 2013. Galectin-3: clinical utility and prognostic value in patients with heart failure. Research Reports in Clinical Cardiology 4, 13-22. DOI: 10.2147/rrcc.s28562 |
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Vigdis Hillestad, Frank Kramer, Stefan Golz, Andreas Knorr, Kristin B. Andersson and Geir Christensen. 2013. Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene. Journal of Applied Physiology 115, 10, 1572-1580. DOI: 10.1152/japplphysiol.01044.2012 |
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Gülsüm Erkilet, Cenk Özpeker, Dietmar Böthig, Frank Kramer, Daniela Röfe, Birte Bohms, Michiel Morshuis, Jan Gummert and Hendrik Milting. 2013. The biomarker plasma galectin-3 in advanced heart failure and survival with mechanical circulatory support devices. The Journal of Heart and Lung Transplantation 32, 2, 221-230. DOI: 10.1016/j.healun.2012.11.011 |
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2012 |
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Werner Nickl, Reiner Füth, Jan Smettan, Till Köhler, Mark Lankisch, Frank Kramer, Thomas Krahn, Michael Coll Barroso, Rolf Michael Klein and Wilfried Dinh. 2012. Assessment of aortic valve area combining echocardiography and magnetic resonance imaging. Arquivos Brasileiros de Cardiologia 98, 3, 234-242. DOI: 10.1590/s0066-782x2012005000017 |
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Frank Kramer and Alex Dusek. 2012. Biomarkers of lung tissue remodeling in pulmonary diseases: implications for clinical practice and research. Current Respiratory Medicine Reviews 8, 2, 100-107. DOI: 10.2174/157339812799859770 |
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2011 |
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Frank Kramer, S. Schwenke, T. Krahn and Christina Schumann. 2011. Biomarker der Inflammation, des Gewebe-Remodelings und der vaskulären Durchlässigkeit in PH- und COPD-Patienten. Pneumologie 65, S02, S120-S121. DOI: 10.1055/s-0030-1256813 |
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Khusru Asadullah and Frank Kramer. 2011. Biomarkers for intensive care medicine patients: the (stony) path into a bright future?. Biomarkers 16, sup1, S1-S4. DOI: 10.3109/1354750x.2010.549571 |
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M. Coll Barroso, W. Nickl, C. Schumacher, B. Bjarnason-Wehrens, Frank Kramer, T. Krahn, U. Wehmeier, W. Dinh and T. Hilberg. 2011. Cardiac Power Output: Diagnostisches Tool zur Beurteilung der Belastungslimitation und Risikostratifizierung der diastolischen Herzinsuffizienz? Eine Pilotstudie. Deutsche Zeitschrift für Sportmedizin 62, 7-8, 195. |
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Markus Schwefer, Aleksandra Mandecka, Helen Schmicker-Helf, Andreas Brückmann, Thomas Lehmann, Ingeburg Schauer, Frank Kramer, Marcus Blum and Harald Lapp. 2011. Dynamic Vessel Analyzer (DVA) – a new method to detect endothelial dysfunction in chronic heart failure: correlation between DVA and asymmetric dimethyl arginine (ADMA). BMC Pharmacology 11, Suppl 1, P66. DOI: 10.1186/1471-2210-11-s1-p66 |
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Wilfried Dinh, Reiner Füth, Mark Lankisch, Georg Hess, Dietmar Zdunek, Thomas Scheffold, Frank Kramer, Rolf Michael Klein, Michael Coll Barroso and Werner Nickl. 2011. Growth-differentiation factor-15: A novel biomarker in patients with diastolic dysfunction?. Arquivos Brasileiros de Cardiologia 97, 1, 65-75. DOI: 10.1590/s0066-782x2011005000058 |
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Wilfried Dinh, Mark Lankisch, Werner Nickl, Milvia Gies, Daniel Scheyer, Frank Kramer, ThOmas Scheffold, ThOmas Krahn, Armin Sause and Reiner Füth. 2011. Metabolic syndrome with or without diabetes contributes to left ventricular diastolic dysfunction. Acta Cardiologica 66, 2, 167-174. DOI: 10.1080/ac.66.2.2071247 |
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Frank Kramer and Hendrik Milting. 2011. Novel biomarkers in human terminal heart failure and under mechanical circulatory support. Biomarkers 16, Suppl1, S31-S41. DOI: 10.3109/1354750x.2011.561498 |
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2010 |
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Christian Schumann, Philipp M. Lepper, Hedwig Frank, Roland Schneiderbauer, Thomas Wibmer, Cornelia Kropf, Kathrin M. Stoiber, Stefan Rüdiger, Lothar Kruska, Thomas Krahn and Frank Kramer. 2010. Circulating biomarkers of tissue remodelling in pulmonary hypertension. Biomarkers 15, 6, 523-532. DOI: 10.3109/1354750x.2010.492431 |
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Wilfried Dinh, Mark Lankisch, Werner Nickl, Daniel Scheyer, Thomas Scheffold, Frank Kramer, Thomas Krahn, Rolf M Klein, Michael Barroso and Reiner Füth. 2010. Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study. Cardiovascular Diabetology 9, 63. DOI: 10.1186/1475-2840-9-63 |
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Wilfried Dinh, Werner Nickl and Frank Kramer. 2010. Letter by Dinh et al Regarding the Article, “Simultaneous Assessment of Unprocessed ProBNP 1–108 in Addition to Processed BNP32 Improves Identification of High-Risk Ambulatory Patients With Heart Failure”. Circulation: Heart Failure 3, 4, e26. DOI: 10.1161/circheartfailure.110.949529 |
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Wilfried Dinh, Werner Nickl, Jan Smettan, Frank Kramer, Thomas Krahn, Thomas Scheffold, Michael Coll Barroso, Hilmar Brinkmann, Till Koehler, Mark Lankisch and Reiner Füth. 2010. Reduced global longitudinal strain in association to increased left ventricular mass in patients with aortic valve stenosis and normal ejection fraction: a hybrid study combining echocardiography and magnetic resonance imaging. Cardiovascular Ultrasound 8, 1, 29. DOI: 10.1186/1476-7120-8-29 |
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2009 |
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M. Klein, R. Schermuly, P. Ellinghaus, Frank Kramer and S. Schäfer. 2009. Anti-Remodeling-Ansätze in der Therapie der pulmonalen Hypertonie. Pneumologie 64, S01, S18-S19. DOI: 10.1055/s-0029-1215186 |
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Christina Schumann, R. Schneiderbauer, H. Frank, K. Doering, T. Wibmer, C. Kropf, L. Hundack, T. Merk, P. M. Lepper, T. Krahn and Frank Kramer. 2009. Beurteilung von Serum Biomarkern des kardiopulmonalen Gewebeumbaus in der Pulmonalen Hypertonie. Pneumologie 63, S01, V210. DOI: 10.1055/s-0029-1213990 |
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S. Schafer, P. Ellinghaus, W. Janssen, Frank Kramer, K. Lustig, H. Milting, R. Kast and M. Klein. 2009. Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling. Cardiovascular Research 82, 1, 30-39. DOI: 10.1093/cvr/cvp002 |
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Frank Kramer, T. Krahn and Christina Schumann. 2009. Serum-Biomarker des kardiopulmonalen Gewebeumbaus bei Pulmonaler Hypertonie. Pneumologie 64, S01, S5-S6. DOI: 10.1055/s-0029-1215165 |
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2008 |
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Frank Kramer, Jan Torzewski, Joachim Kamenz, Kerstin Veit, Vinzenz Hombach, Jürgen Dedio and Yuri Ivashchenko. 2008. Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB- and C/EBPβ-dependent autocrine interleukin-6 loop. Molecular Immunology 45, 9, 2678-2689. DOI: 10.1016/j.molimm.2007.12.017 |
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Hendrik Milting, Peter Ellinghaus, Michael Seewald, Hamdin Cakar, Birte Bohms, Astrid Kassner, Reiner Körfer, Martina Klein, Thomas Krahn, Lothar Kruska, Aly El Banayosy and Frank Kramer. 2008. Plasma Biomarkers of Myocardial Fibrosis and Remodeling in Terminal Heart Failure Patients Supported by Mechanical Circulatory Support Devices. The Journal of Heart and Lung Transplantation 27, 6, 589-596. DOI: 10.1016/j.healun.2008.02.018 |
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Frank Kramer, Peter Sandner, Martina Klein and Thomas Krahn. 2008. Plasma concentrations of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin reflect severity of heart failure in DOCA-salt hypertensive rat. Biomarkers 13, 3, 270-281. DOI: 10.1080/13547500801903123 |
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2007 |
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M. Klein, Frank Kramer, S. Golz, F. von Nussbaum, R. Kast and S. Schaefer. 2007. Anti-remodeling and anti-inflammatory effects of elastase inhibition in a rat model of pulmonary hypertension and right heart failure. European Heart Journal 28, Supplement 1, 55. DOI: 10.1093/eurheartj/ehm417 |
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2005 |
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Yuri Ivashchenko, Frank Kramer, Stefan Schäfer, Andrea Bucher, Kerstin Veit, Vinzenz Hombach, Andreas Busch, Olaf Ritzeler, Jürgen Dedio and Jan Torzewski. 2005. Protein kinase C pathway is involved in transcriptional regulation of C-reactive protein synthesis in human hepatocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 1, 186-192. DOI: 10.1161/01.atv.0000150041.81963.68 |