Biochemistry and Molecular Biology

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Research - Protein Analytics

© Mia Mielenz
Our research group is passionate about understanding how proteins and glycans shape cell function and diseases. With mass spectrometry-based proteomics, xCGE-LIF-based glycan analysis, bioinformatics, glycobiochemistry, and cell biology, we study their roles in cell communication, development, cancer, and rare congenital disorders of glycosylation.
 
In parallel, we are developing innovative analytical workflows and establishing a Proteomics Core Facility at the Medical Faculty of the University of Augsburg to support interdisciplinary biomedical research.
 
Our main research areas include:
 
Quantitative proteomics, subcellular proteome analysis, secretomics, and the investigation of posttranslational modifications.
 
Structural characterization and sensitive analysis of N-glycans and glycosphingolipid-derived glycans using xCGE-LIF.
 
Investigation of tumor-specific glycan and glycosphingolipid signatures to identify novel biomarkers and potential therapeutic targets.
 
Research on ER-associated glycosylation processes, particularly C- and O-mannosylation, and their biological functions in development and disease.

 

 

 

© Mia Mielenz

News

FOR2952 Annual Meeting in Erlangen
June 1, 2026

FOR2952 Annual Meeting in Erlangen

On June 1st and 2nd, 2026, our community gathered once again in Erlangen for the Annual Meeting. The two-day event provided a valuable platform for presenting recent achievements, exchanging ideas, and strengthening collaborations across projects and research areas. Beyond the scientific programme, everyone enjoyed a visit to the Bergkirchweih, Erlangen’s famous beer festival, making the meeting both productive and memorable.

Invitation to the 109th Annual Meeting of the German Society of Pathology
May 29, 2026

Invitation to the 109th Annual Meeting of the German Society of Pathology

We are delighted that our PostDoc, Dr. Julia Beimdiek, was invited to give an oral presentation at the 109th Annual Meeting of the German Society of Pathology. Presenting her glycan-based research to an audience of pathologists is a wonderful opportunity. In her talk "Spotting Disease in Glycan Signatures" she shared exciting insights from our glycomic research.

Lunch-Symposium at Universitätsklinikum Augsburg
May 28, 2026

Lunch-Symposium at Universitätsklinikum Augsburg

Over sandwiches and snacks, Prof. Falk Büttner presented recent findings on the identification of a glycan-based urinary biomarker for bladder cancer at the Universitätsklinikum Augsburg. Employees from across the clinic were invited to join the lunch symposium and learn more about the analytical approaches underlying this promising discovery.

At the 77th Mosbacher Kolloquium
March 25, 2026

At the 77th Mosbacher Kolloquium

Five members of our group participated in the 77th Mosbacher Kolloquium “More than lipidic barriers – New horizons in membrane biology.” PhD students Christina Hopf, Sankritya Sarma, and Inês Moreira, together with research assistant Mia Mielenz and postdoctoral researcher Dr. Julia Beimdiek, presented their work to the international community. The conference brought together leading experts in membrane biology and lipid research, offering a stimulating environment for discussion and new ideas.

Article in “Verlagsbeilage der Augsburger Allgemeinen”
Oct. 20, 2025

Article in “Verlagsbeilage der Augsburger Allgemeinen”

We are delightet to shrare that our groups findings on early bladder cancer markers are highlighted in an article of the exclusiv additon “Spitzenmedizin” of the newspaper “Augsburger Allgemeine”. This aricle is a great oppurtunity to share scientific reseach with a wider audience.

Mothers in Science Caregiver Travel Grant awarded
Sept. 22, 2025

Mothers in Science Caregiver Travel Grant awarded

Great news! Our PhD student, Inês Moreira, has been selected as a recipient of the Mothers in Science Caregiver Travel Grant. This award supports researchers with caregiving responsibilities, enabling Inês to attend an international conference and strengthen her scientific network while balancing family life.

Cover of Cell Reports Medicine
Aug. 19, 2025

Cover of Cell Reports Medicine

We are excited to share that our group’s work is highlighted on the cover of the August issue of Cell Reports Medicine. The artwork, entitled “Sweet clues in sour places,” illustrates our team’s discovery that while multiple glycans are detectable in tumors, only nLc4 (highlighted in red) is selectively increased in urine. This creative visual metaphor reflects the identification of nLc4 as a promising non-invasive biomarker for bladder cancer detection.

New paper on bladder cancer biomarkers published in Cell Reports Medicine
Aug. 19, 2025

New paper on bladder cancer biomarkers published in Cell Reports Medicine

We are proud to announce the publication of our group’s original research article “Neolactotetraosylceramide enables urinary detection of bladder cancer” in Cell Reports Medicine.This study identifies nLc4 as a promising non-invasive biomarker for bladder cancer detection, advancing our understanding of glycosphingolipids in oncology.

Annual Meeting of the FOR2953
June 16, 2025

Annual Meeting of the FOR2953

Sialic Acid as Regulator in Development and Immunity. Our Annual Meeting 2025 was held on June 16–17, 2025, in Erlangen and brought together the research group FOR2953 for inspiring progress reports, engaging discussions, and lively scientific exchange during the poster session. The meeting concluded on a celebratory note with a visit to the Bergkirchweih, Erlangen’s traditional beer festival.

Best Oral Presentation at an international symposium in Ireland
June 12, 2025

Best Oral Presentation at an international symposium in Ireland

Congratulations to our PhD student, Inês Moreira, who received the Best Oral Presentation Award at the 16th Jenner Glycobiology and Medicine Symposium in Maynooth, Ireland. She presented her research on glycosphingolipids in bladder cancer, sparking engaging discussions with leading experts in the field.

Panel Discussion with Prof. Falk Büttner: From the idea to a start-up
May 7, 2025

Panel Discussion with Prof. Falk Büttner: From the idea to a start-up

How do I successfully patent a promising product? What should I bear in mind when founding a start-up? Who can I approach with my questions? Where can I get support? Similar questions were discussed with our guests from the biomedical start-up scene, the University of Augsburg and Augsburg University Hospital.

Best Talk Award at the CCC-N Young Cancer Scientist Symposium
April 25, 2025

Best Talk Award at the CCC-N Young Cancer Scientist Symposium

We are delighted to share that our PhD student, Inês Moreira, was honored with the Best Talk Award at the 3rd CCC-N Young Cancer Scientist Symposium in Göttingen, Germany. Her presentation on bladder cancer glycobiology was recognized for its scientific significance and clarity of communication.

Review article on glycosphingolipids in bladder cancer published in Discover Oncology
April 19, 2025

Review article on glycosphingolipids in bladder cancer published in Discover Oncology

Our group contributed to the Special Issue “Role of Glycolipids in Cancer” in Discover Oncology with a review article entitled “Glycosphingolipids as emerging attack points in bladder cancer.” In this publication, our PhD student Inês Moreira and group leader Falk Buettner highlight how glycosphingolipids may serve as novel targets and biomarkers in bladder cancer, summarizing current advances and outlining future perspectives.

From Candidate to Doctor: Congratulations!
Dec. 4, 2024

From Candidate to Doctor: Congratulations!

We are thrilled to share that Julia Beimdiek has successfully defended her PhD thesis on “Technical Advancement of Multiplexed Capillary Gel Electrophoresis Coupled to Laser-Induced Fluorescence Detection (xCGE-LIF)-Based Glycan Analytics and Application to Biomedical Research”. The defense was a celebration of her hard work, scientific curiosity, and dedication — and of course, a well-deserved moment to relax and enjoy the accomplishment. Congratulations!

Oral presentation at the Joint Glycobiology Meeting
Sept. 29, 2024

Oral presentation at the Joint Glycobiology Meeting

We are pleased to share that our PhD student, Inês Moreira, was selected for an oral presentation at the 33rd Joint Glycobiology Meeting in Hannover, Germany. Her talk “Neolactotetraosylceramide is a novel biomarker for bladder cancer” attracted great interest and stimulated discussion among leading experts in glycobiology and oncology.

ISSCR Conference in Hamburg
July 10, 2024

ISSCR Conference in Hamburg

International Society for Stem Cell Research. Our team members, Jonas Kaynert and Julia Beimdiek, attended the ISSCR Annual Meeting 2024 in Hamburg, Germany. The conference offered inspiring presentations, cutting-edge research updates, and lively scientific exchanges — with a brief but enjoyable interlude at the Musical Hercules.

Speed talk at an international conference in Portugal
May 11, 2023

Speed talk at an international conference in Portugal

We are proud to share that our PhD student, Inês Moreira, was selected for a speed talk at the 29th Porto Cancer Meeting in Porto, Portugal. Her presentation “Neolactotetraosylceramide is a novel biomarker for bladder cancer” showcased promising advances in cancer glycobiology.

Oral presentation at GlycoBioTec 2023
Jan. 17, 2023

Oral presentation at GlycoBioTec 2023

We are pleased to share that both our PhD student, Inês Moreira (“Neolactotetraosylceramide is a novel biomarker for bladder cancer” ), as well as our postdoctoral researcher, Dr. Charlotte Rossdam (“Lacto-N-tetraosyl ceramide is a novel marker for human pluripotent stem cells”) were selected for an oral presentation at GlycoBioTec 2023 in Berlin, Germany. Their talks introduced recent findings to an international audience of glycobiology researchers.

Oral Presentation, Poster Prize, and Travel Award at GRC Glycolipid and Sphingolipid Biology
April 2, 2022

Oral Presentation, Poster Prize, and Travel Award at GRC Glycolipid and Sphingolipid Biology

We are delighted to share that our PhD student, Julia Beimdiek, was honored with a FEBBS Letters Poster Prize and Travel Award at the GRC conference in Lucca, Italy. In addition she presented her research "Generation and Examination of sphingolipid-depleted human iPSCs and their derivatives" live on stage to an international audience of researchers.

Poster Prize awarded at the Annual Meeting of the Society for Glycobiology (SFG)
Nov. 1, 2021

Poster Prize awarded at the Annual Meeting of the Society for Glycobiology (SFG)

We are delighted to share that our PhD student, Julia Beimdiek, was honored with a Poster Prize at the annual meeting of the Society for Glycobiology in San Diego, USA. The theme of this year's meeting was “Glycobiology at the Forefront of Human Health and Disease”. The award was received for the poster entitled "CDG-IIb Syndrome: In-Depth Glycomic Characterization of a novel patient using xCGE-LIF“.

Learn more about our Group members

Team Büttner

Publications

2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005

2026
Dong Chengji, Zhong Xiaowei, Peng Qi, Müller Zoe, Beimdiek Julia, Splith Katrin, Feldbrügge Linda, Cantz Tobias, Singh Manvendra K., Buettner Falk F. R., Bantel Heike, Wedemeyer Heiner, Ott Michael, Balakrishnan Asha, Sharma Amar Deep. Impaired glycoRNA biogenesis in metabolic-dysfunction associated steatotic liver disease. Journal of Hepatology 2026; https://doi.org/10.1016/j.jhep.2026.04.034
BibTeX | RIS | DOI
Albers Malena, Bosse Lydia, Schröter Larissa, Junemann Anna-Maria T., Rossdam Charlotte, Hartmann Maike, Grove Melanie, Litfin Thomas, Egger Anna-Sophia, Kwiatkowski Marcel, Thedieck Kathrin, Zocher Georg, Buettner Falk F. R., Malde Alpeshkumar K., von Itzstein Mark, Mühlenhoff Martina. Interplay of SLC33A1-dependent and -independent Golgi sialic acid O-acetylation in CASD1 catalysis. Nature Communications 2026;17(1):3156. https://doi.org/10.1038/s41467-026-71333-y
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Konze Sarah A., Beimdiek Julia, Oberbeck Astrid, Buettner Falk F. R.. JAM-A as a potential surface marker of human pluripotent stem cells. Journal of Proteomics 2026;330:105680. https://doi.org/10.1016/j.jprot.2026.105680
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Juchem Malte, Ersoy Sedef, Oehlsen Lea, Ye Jia L., Weber Natalie, Xiao Ke, Jahn Christopher, Eggenschwiler Reto, Cantz Tobias, Beimdiek Julia, Buettner Falk F. R., Kraft Theresia, Baer Christian, Hoepfner Jeannine, Thum Thomas. Nucleoside-modified GLA mRNA rescues fabry cardiomyopathy phenotypes in human iPSC-derived cardiomyocytes [Abstract]. European Journal of Heart Failure 2026;28(Supplement 1):xuag034.055. https://doi.org/10.1093/ejhf/xuag034.055
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Buettner Falk, Claus Rainer. Proteomik und Glykomik in der Pathologie: Potential von Autopsie- und FFPE-Gewebe in Diagnostik und Forschung. Die Pathologie 2026;47(3):166-174. https://doi.org/10.1007/s00292-026-01549-8
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2025
Olivares Rivera Arturo, Held Julia, Beimdiek Julia, Buettner Falk F. R., Heußel Claus P., Janciauskiene Sabina, Trudzinski Franziska. Characterization of alpha-1 antitrypsin in a Pi*ZZ patient with emphysema: a case report. Respiratory Medicine Case Reports 2025;58:102305. https://doi.org/10.1016/j.rmcr.2025.102305
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Staffeldt Lisa, Maar Hanna, Beimdiek Julia, Chambers Samuel, Riecken Kristoffer, von Itzstein Mark, Buettner Falk F. R., Everest-Dass Arun, Lange Tobias. Depletion of β1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells. Neoplasia 2025;59:101083. https://doi.org/10.1016/j.neo.2024.101083
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Marquardt Anja, Münchhoff Marcus S., Krohn Jacqueline, Palarz Philip M., Taft Manuel H., Greve Johannes N., Di Donato Nataliya, Buettner Falk F. R., Manstein Dietmar J.. Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation. FEBS Letters 2025;599(17):2449-2462. https://doi.org/10.1002/1873-3468.70088
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Moreira Inês B., Buettner Falk F. R.. Glycosphingolipids as emerging attack points in bladder cancer. Discover Oncology 2025;16(1):569. https://doi.org/10.1007/s12672-025-02302-y
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Moreira Inês B., Rossdam Charlotte, Kaynert Jonas, Beimdiek Julia, Vicente Manuel M., Schmitz Jessica, Großhennig Anika, Oberbeck Astrid, Hoffmann Michèle J., Rosero Moreno Michele E., Steinbach Daniel, Barcena Maria L., Lippka Yannick, Bräsen Jan H., Tezval Hossein, Buettner Falk F. R.. Neolactotetraosylceramide enables urinary detection of bladder cancer. Cell Reports Medicine 2025;6(8):102246. https://doi.org/10.1016/j.xcrm.2025.102246
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Kohrs Lisa, Büttner Falk F. R., Lokau Juliane, Garbers Christoph. The biology of interleukin-6 family cytokines is regulated by glycosylation. Biochemical Journal 2025;482(10):535-551. https://doi.org/10.1042/BCJ20240769
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Rhode Johannes, Hagenau Lisa, Edwards Stephanie, Buettner Falk F. R., Tzvetkova Ana, Jensen Lars R., Kuss Andreas W.. Three modified human IPSC lines containing mutations in the distal DEHMBA associated locus of the SRCAP gene. Stem Cell Research 2025;89:103847. https://doi.org/10.1016/j.scr.2025.103847
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Litschko Christa, Di Domenico Valerio, Schulze Julia, Li Sizhe, Ovchinnikova Olga G., Voskuilen Thijs, Bethe Andrea, Cifuente Javier O., Marina Alberto, Budde Insa, Mast Tim A., Sulewska Małgorzata, Berger Monika, Buettner Falk F. R., Lowary Todd L., Whitfield Chris, Codée Jeroen D. C., Schubert Mario, Guerin Marcelo E., Fiebig Timm. Transition transferases prime bacterial capsule polymerization. Nature Chemical Biology 2025;21:120-130. https://doi.org/10.1038/s41589-024-01664-8
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2024
Karsten Christina B., Büttner Falk F. R., Cajic Samanta, Nehlmeier Inga, Roshani Berit, Klippert Antonina, Sauermann Ulrike, Stolte-Leeb Nicole, Reichl Udo, Gerardy-Schahn Rita, Rapp Erdmann, Stahl-Hennig Christiane, Pöhlmann Stefan. Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity. PLoS Pathogens 2024;20(5):e1012190. https://doi.org/10.1371/journal.ppat.1012190
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Kespohl Birte, Hegele Anna‐Lena, Düsterhöft Stefan, Bakker Hans, Büttner Falk F. R., Hartig Roland, Lokau Juliane, Garbers Christoph. Molecular characterization of the craniosynostosis‐associated interleukin‐11 receptor variants p.T306_S308dup and p.E364_V368del. The FEBS Journal 2024;291(8):1667-1683. https://doi.org/10.1111/febs.17015
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Thom Jonas, Roters Nathalie, Schuemann Slavica, Andrée Birgit, Büttner Falk F. R., Hilfiker Andres, Goecke Tobias, Ramm Robert. Reduction in xenogeneic epitopes on porcine endothelial cells by periodate oxidation. Biomedicines 2024;12(7):1470. https://doi.org/10.3390/biomedicines12071470
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2023
Sulewska Małgorzata, Berger Monika, Damerow Manuela, Schwarzer David, Büttner Falk F. R., Bethe Andrea, Taft Manuel H., Bakker Hans, Mühlenhoff Martina, Gerardy-Schahn Rita, Priem Bernard, Fiebig Timm. Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection. Carbohydrate Polymers 2023;319:121182. https://doi.org/10.1016/j.carbpol.2023.121182
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Moreira Inês B., Rossdam Charlotte, Beimdiek Julia, Vicente Manuel M., Schmitz Jessica, Oberbeck Astrid, Bräsen Jan H., Tezval Hossein, Büttner Falk F. R.. Neolactotetraosylceramide: a novel non-invasive urinary biomarker for bladder cancer. preprint; 2023. https://doi.org/10.1101/2023.08.08.552442
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Burock Robert, Cajic Samanta, Hennig René, Büttner Falk F. R., Reichl Udo, Rapp Erdmann. Reliable N-glycan analysis–removal of frequently occurring oligosaccharide impurities by enzymatic degradation. Molecules 2023;28(4):1843. https://doi.org/10.3390/molecules28041843
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Rossdam Charlotte, Brand Smilla, Beimdiek Julia, Oberbeck Astrid, Albers Marco Darius, Naujok Ortwin, Büttner Falk F. R.. Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells. preprint; 2023. https://doi.org/10.1101/2023.08.30.555456
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Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Sörensen-Zender Inga, Fenske Arno, Weinhold Birgit, Schmitt Roland, Tiede Andreas, Büttner Falk F. R., Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects against complement attack. Cell Death Discovery 2023;9(1):395. https://doi.org/10.1038/s41420-023-01686-6
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2022
Hütte Hermann J., Tiemann Birgit, Shcherbakova Aleksandra, Grote Valerian, Hoffmann Marcus, Povolo Lorenzo, Lommel Mark, Strahl Sabine, Vakhrushev Sergey Y., Rapp Erdmann, Büttner Falk F. R., Halim Adnan, Imberty Anne, Bakker Hans. A bacterial mannose binding lectin as a tool for the enrichment of C- and O-mannosylated peptides. Analytical Chemistry 2022;94(20):7329-7338. https://doi.org/10.1021/acs.analchem.2c00742
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Seegers Carla I. I., Ramón Roth Isabel, Zarnovican Patricia, Büttner Falk F. R., Routier Françoise H.. Characterization of a gene cluster involved in Aspergillus fumigatus zwitterionic glycosphingolipid synthesis. Glycobiology 2022;32(9):814-824. https://doi.org/10.1093/glycob/cwac036
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Pradhan Pooja, Vijayan Vijith, Cirksena Karsten, Büttner Falk F. R., Igarashi Kazuhiko, Motterlini Roberto, Foresti Roberta, Immenschuh Stephan. Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. Redox Biology 2022;51:102265. https://doi.org/10.1016/j.redox.2022.102265
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Cumin Cécile, Huang Yen-Lin, Rossdam Charlotte, Ruoff Felix, Céspedes Susana Posada, Liang Ching-Yeu, Lombardo Flavio C., Coelho Ricardo, Rimmer Natalie, Konantz Martina, López Mónica Núñez, Alam Shahidul, Schmidt Alexander, Calabrese Diego, Fedier Andre, Vlajnic Tatjana, von Itzstein Mark, Templin Markus, Büttner Falk F. R., Everest-Dass Arun, Heinzelmann-Schwarz Viola, Jacob Francis. Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Reports 2022;40(7):111181. https://doi.org/10.1016/j.celrep.2022.111181
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Janciauskiene Sabina, Tumpara Srinu, Schebb Nils Helge, Büttner Falk F. R., Mainka Malwina, Sivaraman Kokilavani, Immenschuh Stephan, Grau Veronika, Welte Tobias, Olejnicka Beata. Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs. Frontiers in Pharmacology 2022;13:995869. https://doi.org/10.3389/fphar.2022.995869
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Beimdiek Julia, Janciauskiene Sabina, Wrenger Sabine, Volland Sonja, Rozy Adriana, Fuge Jan, Olejnicka Beata, Pink Isabell, Illig Thomas, Popov Alexander, Chorostowska Joanna, Büttner Falk F. R., Welte Tobias. Plasma markers of COVID-19 severity: a pilot study. Respiratory Research 2022;23(1):343. https://doi.org/10.1186/s12931-022-02272-7
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Beimdiek Julia, Hennig René, Burock Robert, Puk Oliver, Biskup Saskia, Rapp Erdmann, Lesinski-Schiedat Anke, Büttner Falk F. R., Das Anibh M.. Serum N-glycomics of a novel CDG-IIb patient reveals aberrant IgG glycosylation. Glycobiology 2022;32(5):380-390. https://doi.org/10.1093/glycob/cwac003
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Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Tiede Andreas, Büttner Falk F. R., Weinhold Birgit, Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects trophoblasts, erythrocytes and endothelial cells against complement attack. preprint; 2022. https://doi.org/10.1101/2022.01.24.477475
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2021
Janosz Ewa, Hetzel Miriam, Spielmann Hanna, Tumpara Srinu, Rossdam Charlotte, Schwabbauer Marc, Kloos Doreen, von Kaisenberg Constantin, Schambach Axel, Büttner Falk F. R., Janciauskiene Sabina, Lachmann Nico, Moritz Thomas. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. Gene Therapy 2021;28(9):477-493. https://doi.org/10.1038/s41434-021-00269-3
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Taubert Richard, Engel Bastian, Diestelhorst Jana, Hupa‐Breier Katharina L., Behrendt Patrick, Baerlecken Niklas T., Sühs Kurt‐Wolfram, Janik Maciej K., Zachou Kalliopi, Sebode Marcial, Schramm Christoph, Londoño María‐Carlota, Habes Sarah, Oo Ye H., Lalanne Claudine, Pape Simon, Schubert Maren, Hust Michael, Dübel Stefan, Thevis Mario, Jonigk Danny, Beimdiek Julia, Büttner Falk F. R., Drenth Joost P. H., Muratori Luigi, Adams David H., Dyson Jessica K., Renand Amédée, Graupera Isabel, Lohse Ansgar W., Dalekos George N., Milkiewicz Piotr, Stangel Martin, Maasoumy Benjamin, Witte Torsten, Wedemeyer Heiner, Manns Michael P., Jaeckel Elmar. Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis. Hepatology 2021;75(1):13-27. https://doi.org/10.1002/hep.32134
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Cirksena Karsten, Hütte Hermann J., Shcherbakova Aleksandra, Thumberger Thomas, Sakson Roman, Weiss Stefan, Jensen Lars Riff, Friedrich Alina, Todt Daniel, Kuss Andreas W., Ruppert Thomas, Wittbrodt Joachim, Bakker Hans, Büttner Falk F. R.. The C-mannosylome of human induced pluripotent stem cells implies a role for ADAMTS16 C-mannosylation in eye development. Molecular and Cellular Proteomics 2021;20:100092. https://doi.org/10.1016/j.mcpro.2021.100092
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2020
Jirmo Adan C., Rossdam Charlotte, Grychtol Ruth, Happle Christine, Gerardy‐Schahn Rita, Büttner Falk F. R., Hansen Gesine. Differential expression patterns of glycosphingolipids and C‐type lectin receptors on immune cells in absence of functional regulatory T cells. Immunity, Inflammation and Disease 2020;8(4):512-522. https://doi.org/10.1002/iid3.334
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Dettmer Rabea, Cirksena Karsten, Münchhoff Julia, Kresse Jasmin, Diekmann Ulf, Niwolik Isabell, Büttner Falk F. R., Naujok Ortwin. FGF2 inhibits early pancreatic lineage specification during differentiation of human embryonic stem cells. Cells 2020;9(9):1927. https://doi.org/10.3390/cells9091927
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Klaus Christine, Hansen Jan N., Ginolhac Aurélien, Gérard Deborah, Gnanapragassam Vinayaga S., Horstkorte Rüdiger, Rossdam Charlotte, Büttner Falk F. R., Sauter Thomas, Sinkkonen Lasse, Neumann Harald, Linnartz-Gerlach Bettina. Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. Neurobiology of Aging 2020;88:91-107. https://doi.org/10.1016/j.neurobiolaging.2020.01.008
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Fiebig Timm, Cramer Johannes T., Bethe Andrea, Baruch Petra, Curth Ute, Führing Jana I., Büttner Falk F. R., Vogel Ulrich, Schubert Mario, Fedorov Roman, Mühlenhoff Martina. Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nature Communications 2020;11(1). https://doi.org/10.1038/s41467-020-18464-y
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Starzonek Sarah, Maar Hanna, Labitzky Vera, Wicklein Daniel, Rossdam Charlotte, Büttner Falk F. R., Wolters-Eisfeld Gerrit, Guengoer Cenap, Wagener Christoph, Schumacher Udo, Lange Tobias. Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology 2020;30(9):695-709. https://doi.org/10.1093/glycob/cwaa019
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2019
Rossdam Charlotte, Konze Sarah A., Oberbeck Astrid, Rapp Erdmann, Gerardy-Schahn Rita, von Itzstein Mark, Büttner Falk F. R.. Approach for profiling of glycosphingolipid glycosylation by multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection To identify cell-surface markers of human pluripotent stem cells and derived cardiomyocytes. Analytical Chemistry 2019;91(10):6413-6418. https://doi.org/10.1021/acs.analchem.9b01114
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Albuquerque-Wendt Andreia, Jacot Damien, Dos Santos Pacheco Nicolas, Seegers Carla, Zarnovican Patricia, Büttner Falk F. R., Bakker Hans, Soldati-Favre Dominique, Routier Françoise H.. C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence. Journal of Biological Chemistry 2019;295(4):1066-1076. https://doi.org/10.1074/jbc.ra119.010590
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Shcherbakova Aleksandra, Preller Matthias, Taft Manuel H., Pujols Jordi, Ventura Salvador, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. C-mannosylation supports folding and enhances stability of thrombospondin repeats. eLife 2019;8:e52978. https://doi.org/10.7554/elife.52978
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Diekmann Ulf, Wolling Hanna, Dettmer Rabea, Niwolik Isabell, Naujok Ortwin, Büttner Falk F. R.. Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture. Scientific Reports 2019;9(1). https://doi.org/10.1038/s41598-018-37650-z
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Konze Sarah A., Abraham Wolf-Rainer, Goethe Elke, Surges Esther, Kuypers Marcel M. M., Hoeltig Doris, Meens Jochen, Vogel Charlotte, Stiesch Meike, Valentin-Weigand Peter, Gerlach Gerald-F., Büttner Falk F. R.. Link between heterotrophic carbon fixation and virulence in the porcine lung pathogen Actinobacillus pleuropneumoniae. Infection and Immunity 2019;87(9). https://doi.org/10.1128/iai.00768-18
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Albuquerque-Wendt Andreia, Hütte Hermann J., Büttner Falk F. R., Routier Françoise H., Bakker Hans. Membrane topological model of glycosyltransferases of the GT-C superfamily. International Journal of Molecular Sciences 2019;20(19):4842. https://doi.org/10.3390/ijms20194842
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2018
van Diepen Laura, Büttner Falk F. R., Hoffmann Dirk, Thiesler Christina T., von Bohlen und Halbach Oliver, von Bohlen und Halbach Viola, Jensen Lars R., Steinemann Doris, Edvardson Simon, Elpeleg Orly, Schambach Axel, Gerardy-Schahn Rita, Kuss Andreas W.. A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency. European Journal of Human Genetics 2018;26(12):1773-1783. https://doi.org/10.1038/s41431-018-0220-5
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Stumpp Nico S., Konze Sarah A., Gerardy-Schahn Rita, Stiesch Meike, Büttner Falk F. R.. A single-step transconjugation system for gene deletion in Aggregatibacter actinomycetemcomitans. Journal of Microbiological Methods 2018;148:74-77. https://doi.org/10.1016/j.mimet.2018.04.002
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Hoppe Carolin M., Albuquerque-Wendt Andreia, Bandini Giulia, Leon Deborah R., Shcherbakova Aleksandra, Büttner Falk F. R., Izquierdo Luis, Costello Catherine E., Bakker Hans, Routier Françoise H.. Apicomplexan C-mannosyltransferases modify thrombospondin type I-containing adhesins of the TRAP family. Glycobiology 2018;28(5):333-343. https://doi.org/10.1093/glycob/cwy013
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Wolling Hanna, Konze Sarah A., Höfer Anne, Erdmann Jelena, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Quantitative secretomics reveals extrinsic signals involved in human pluripotent stem cell cardiomyogenesis. PROTEOMICS 2018;18(14):1800102. https://doi.org/10.1002/pmic.201800102
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Pandey Ashutosh, Li-Kroeger David, Sethi Maya K., Lee Tom V., Büttner Falk F. R., Bakker Hans, Jafar-Nejad Hamed. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila notch signaling. Glycobiology 2018;28(11):849-859. https://doi.org/10.1093/glycob/cwy080
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2017
Kommerein Nadine, Stumpp Sascha N., Müsken Mathias, Ehlert Nina, Winkel Andreas, Häussler Susanne, Behrens Peter, Büttner Falk F. R., Stiesch Meike. An oral multispecies biofilm model for high content screening applications. PLOS ONE 2017;12(3). https://doi.org/10.1371/journal.pone.0173973
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Böer Ulrike, Büttner Falk F. R., Schridde Ariane, Klingenberg Melanie, Sarikouch Samir, Haverich Axel, Wilhelmi Mathias. Antibody formation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissue proteins and αGal epitopes and is reduced in healthy vegetarian subjects. Xenotransplantation 2017;24(2):e12288. https://doi.org/10.1111/xen.12288
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Diekmann Ulf, Wolling Hanna, Büttner Falk F. R., Naujok Ortwin. Chemisch-definierte und xenogen-freie Differenzierung humaner embryonaler Stammzellen in endodermale und pankreatische Vorläuferzellen. Diabetologie und Stoffwechsel 2017;12(S 01):S1-S84. https://doi.org/10.1055/s-0037-1601586
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Shcherbakova Aleksandra, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proceedings of the National Academy of Sciences 2017;114(10):2574-2579. https://doi.org/10.1073/pnas.1613165114
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Konze Sarah A., Werneburg Sebastian, Oberbeck Astrid, Olmer Ruth, Kempf Henning, Jara-Avaca Monica, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Proteomic analysis of human pluripotent stem cell cardiomyogenesis revealed altered expression of metabolic enzymes and PDLIM5 isoforms. Journal of Proteome Research 2017;16(3):1133-1149. https://doi.org/10.1021/acs.jproteome.6b00534
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Konze Sarah A., Cajic Samanta, Oberbeck Astrid, Hennig René, Pich Andreas, Rapp Erdmann, Büttner Falk F. R.. Quantitative assessment of Sialo‐glycoproteins and N‐Glycans during cardiomyogenic differentiation of human induced pluripotent stem cells. ChemBioChem 2017;18(13):1317-1331. https://doi.org/10.1002/cbic.201700100
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2016
Kempf Henning, Olmer Ruth, Haase Alexandra, Franke Annika, Bolesani Emiliano, Schwanke Kristin, Robles-Diaz Diana, Coffee Michelle, Göhring Gudrun, Dräger Gerald, Pötz Oliver, Joos Thomas, Martinez-Hackert Erik, Haverich Axel, Büttner Falk F. R., Martin Ulrich, Zweigerdt Robert. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature Communications 2016;7(1):13602. https://doi.org/10.1038/ncomms13602
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Thiesler Christina T., Cajic Samanta, Hoffmann Dirk, Thiel Christian, van Diepen Laura, Hennig René, Sgodda Malte, Weiβmann Robert, Reichl Udo, Steinemann Doris, Diekmann Ulf, Huber Nicolas M. B., Oberbeck Astrid, Cantz Tobias, Kuss Andreas W., Körner Christian, Schambach Axel, Rapp Erdmann, Büttner Falk F. R.. Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG). Molecular and Cellular Proteomics 2016;15(4):1435-1452. https://doi.org/10.1074/mcp.m115.054122
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Behrens Wiebke, Schweinitzer Tobias, McMurry Jonathan L., Loewen Peter C., Büttner Falk F. R., Menz Sarah, Josenhans Christine. Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions. Scientific Reports 2016;6(1). https://doi.org/10.1038/srep23582
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Werneburg Sebastian, Büttner Falk F. R., Erben Larisser, Mathews Mona, Neumann Harald, Mühlenhoff Martina, Hildebrandt Herbert. Polysialylation and lipopolysaccharide‐induced shedding of E‐selectin ligand‐1 and neuropilin‐2 by microglia and THP‐1 macrophages. Glia 2016;64(8):1314-1330. https://doi.org/10.1002/glia.23004
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2015
Baumann Anna-Maria T., Bakkers Mark J. G., Büttner Falk F. R., Hartmann Maike, Grove Melanie, Langereis Martijn A., de Groot Raoul J., Mühlenhoff Martina. 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nature Communications 2015;6(1):7673. https://doi.org/10.1038/ncomms8673
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Krüger Anke Tina, Engel Jakob, Büttner Falk F. R., Routier Françoise H.. Aspergillus fumigatus Cap59-like protein A is involved in α1,3-mannosylation of GPI-anchors. Glycobiology 2015;26(1):30-38. https://doi.org/10.1093/glycob/cwv078
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Engel Jakob, Schmalhorst Philipp S., Krüger Anke Tina, Müller Christina Theda, Büttner Falk F. R., Routier Françoise H. Characterization of an N-acetylglucosaminyltransferase involved in Aspergillus fumigatus zwitterionic glycoinositolphosphoceramide biosynthesis. Glycobiology 2015;25(12):1423-1430. https://doi.org/10.1093/glycob/cwv059
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Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Lüder Carsten G. K., Ferguson Michael A. J., Routier Françoise H.. Depletion of UDP-glucose and UDP-galactose using a Degron system leads to growth cessation of Leishmania major. PLOS Neglected Tropical Diseases 2015;9(11):e0004205. https://doi.org/10.1371/journal.pntd.0004205
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Karsten Christina B., Büttner Falk F. R., Cajic Samanta, Nehlmeier Inga, Neumann Berit, Klippert Antonina, Sauermann Ulrike, Reichl Udo, Gerardy-Schahn Rita, Rapp Erdmann, Stahl-Hennig Christiane, Pöhlmann Stefan. Exclusive decoration of Simian Immunodeficiency Virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in Rhesus Macaques. Journal of Virology 2015;89(22):11727-11733. https://doi.org/10.1128/jvi.01358-15
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Werneburg S., Büttner Falk F. R., Stangel M., Mühlenhoff M., Hildebrandt H.. ISDN2014_0137: NG2 cells and microglia show cell‐type specific expression of polysialic acid attached to different protein carriers. International Journal of Developmental Neuroscience 2015;47(Part_A):39. https://doi.org/10.1016/j.ijdevneu.2015.04.112
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Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Ferguson Michael A. J., Routier Françoise H.. Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis. International Journal for Parasitology 2015;45(12):783-790. https://doi.org/10.1016/j.ijpara.2015.06.004
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Werneburg Sebastian, Büttner Falk F. R., Mühlenhoff Martina, Hildebrandt Herbert. Polysialic acid modification of the synaptic cell adhesion molecule SynCAM 1 in human embryonic stem cell-derived oligodendrocyte precursor cells. Stem Cell Research 2015;14(3):339-346. https://doi.org/10.1016/j.scr.2015.03.001
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2014
Büttner Falk F. R., Moeller Hanna, Konze Sarah. Analysis of E-cadherin mediated cell-cell interactions in human pluripotent stem cells. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014.
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Konze Sarah A., van Diepen Laura, Schröder Anke, Olmer Ruth, Möller Hanna, Pich Andreas, Weißmann Robert, Kuss Andreas W., Zweigerdt Robert, Büttner Falk F. R.. Cleavage of E-Cadherin and β-Catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells. Molecular and Cellular Proteomics 2014;13(4):990-1007. https://doi.org/10.1074/mcp.m113.033423
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Büttner Falk F. R., Thiesler Christina Theda, Hoffmann Dirk, Cajic Samanta, Hennig René. Functional characterization of PMM2-CDG patient-derived iPSCs. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014.
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Büttner Falk F. R., Werneburg Sebastian, Mühlenhoff Martina, Hildebrandt Herbert. Golgi-resident polysialic acid defines distinct brain cell populations. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014.
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Boeer Ulrike, Büttner Falk F. R., Klingenberg Melanie, Antonopoulos Georgios C., Meyer Heiko, Haverich Axel, Wilhelmi Mathias. Immunogenicity of intensively decellularized equine carotid arteries is conferred by the extracellular matrix protein collagen Type VI. PLoS ONE 2014;9(8):e105964. https://doi.org/10.1371/journal.pone.0105964
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Büttner Falk F. R., Thiesler Christina Theda, Hoffmann Dirk, Cajic Samanta, Hennig René. Molecular characterization of hiPSCs from a PMM2-CDG patient revealed aberrant glycosylation. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014.
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2013
Büttner Falk F. R., Ashikov Angel, Tiemann Birgit, Lehle Ludwig, Bakker Hans. C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Molecular Cell 2013;50(2):295-302. https://doi.org/10.1016/j.molcel.2013.03.003
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Büttner Falk F. R., Karsten Christina B., Nehlmeier Inga, Sauermann Ulrike. Impact of host cell-specific glycosylation differences on SIV infectivity and mucosal transmission. Conference on AIDS Vaccine; 7-10 October 2013; Barcelona, Spain ; 2013.
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Sethi Maya K., Büttner Falk F. R., Ashikov Angel, Bakker Hans. In vitro assays of orphan glycosyltransferases and their application to identify notch xylosyltransferases. In: Brockhausen Inka, editor. Glycosyltransferases: methods and protocols. Totowa, NJ: Humana Press; 2013. p. 307-320. https://doi.org/10.1007/978-1-62703-465-4_23
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Lee Tom V., Sethi Maya K., Leonardi Jessica, Rana Nadia A., Büttner Falk F. R., Haltiwanger Robert S., Bakker Hans, Jafar-Nejad Hamed. Negative regulation of notch signaling by xylose. PLoS Genetics 2013;9(6):e1003547. https://doi.org/10.1371/journal.pgen.1003547
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Rollenhagen Manuela, Büttner Falk F. R., Reismann Marc, Jirmo Adan Chari, Grove Melanie, Behrens Georg M. N., Gerardy-Schahn Rita, Hanisch Franz-Georg, Mühlenhoff Martina. Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type O-glycans located between the b2 and c domain. Journal of Biological Chemistry 2013;288(32):22880-22892. https://doi.org/10.1074/jbc.m113.463927
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Bakker Hans, Büttner Falk F. R., Ashikov Angel. The C‐mannosyltransferase. The FASEB Journal 2013;27(S1):824.2. https://doi.org/10.1096/fasebj.27.1_supplement.824.2
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2012
Schwarzer David, Büttner Falk F. R., Browning Christopher, Nazarov Sergey, Rabsch Wolfgang, Bethe Andrea, Oberbeck Astrid, Bowman Valorie D., Stummeyer Katharina, Mühlenhoff Martina, Leiman Petr G., Gerardy-Schahn Rita. A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis. Journal of Virology 2012;86(19):10384-10398. https://doi.org/10.1128/jvi.00801-12
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Keys Timothy G., Freiberger Friedrich, Ehrit Jörg, Krueger Jonas, Eggers Katinka, Büttner Falk F. R., Gerardy-Schahn Rita. A universal fluorescent acceptor for high-performance liquid chromatography analysis of pro- and eukaryotic polysialyltransferases. Analytical Biochemistry 2012;427(2):107-115. https://doi.org/10.1016/j.ab.2012.05.011
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Brauer Carsten, Hennig-Pauka Isabel, Hoeltig Doris, Büttner Falk F. R., Beyerbach Martin, Gasse Hagen, Gerlach Gerald-F., Waldmann Karl-H.. Experimental Actinobacillus pleuropneumoniae challenge in swine: comparison of computed tomographic and radiographic findings during disease. BMC Veterinary Research 2012;8(1):47. https://doi.org/10.1186/1746-6148-8-47
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Ashikov A., Büttner Falk F. R., Tiemann B., Gerardy-Schahn R., Bakker H.. LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Glycobiology 2012;23(3):303-309. https://doi.org/10.1093/glycob/cws153
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Sethi Maya K., Büttner Falk F. R., Ashikov Angel, Krylov Vadim B., Takeuchi Hideyuki, Nifantiev Nikolay E., Haltiwanger Robert S., Gerardy-Schahn Rita, Bakker Hans. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. Journal of Biological Chemistry 2012;287(4):2739-2748. https://doi.org/10.1074/jbc.m111.302406
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2011
Büttner Falk F. R., Konze Sarah A., Maas Alexander, Gerlach Gerald F.. Proteomic and immunoproteomic characterization of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae. Proteome Science 2011;9(1):23. https://doi.org/10.1186/1477-5956-9-23
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2010
Sethi Maya K., Büttner Falk F. R., Krylov Vadim B., Takeuchi Hideyuki, Nifantiev Nikolay E., Haltiwanger Robert S., Gerardy-Schahn Rita, Bakker Hans. Identification of glycosyltransferase 8 Family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. Journal of Biological Chemistry 2010;285(3):1582-1586. https://doi.org/10.1074/jbc.c109.065409
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Büttner Falk F. R., Sethi Maya. Identification of the Xylosyltransferase adding the second Xylose to O-glucosylated notch EGF repeats. Annual Conference of the Society for Glycobiology; November 7 – 10, 2010; St. Pete Beach, FL ; 2010.
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Büttner Falk F. R., Sethi Maya. Notch Xylosyltransferases. Annual Conference of the Society for Glycobiology; November 7 – 10, 2010; St. Pete Beach, FL ; 2010.
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2009
Büttner Falk F. R., Bendalla Ibrahim M., Bossé Janine T., Meens Jochen, Nash John H. E., Härtig Elisabeth, Langford Paul R., Gerlach Gerald‐F.. Analysis of the Actinobacillus pleuropneumoniae HlyX (FNR) regulon and identification of iron‐regulated protein B as an essential virulence factor. PROTEOMICS 2009;9(9):2383-2398. https://doi.org/10.1002/pmic.200800439
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Jores Jörg, Meens Jochen, Büttner Falk F. R., Linz Bodo, Naessens Jan, Gerlach Gerald F.. Analysis of the immunoproteome of Mycoplasma mycoides subsp. mycoides small colony type reveals immunogenic homologues to other known virulence traits in related Mycoplasma species. Veterinary Immunology and Immunopathology 2009;131(3-4):238-245. https://doi.org/10.1016/j.vetimm.2009.04.016
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Kahlisch Dennis, Büttner Falk F. R., Naim Hassan Y., Gerlach Gerald-Friedrich. Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection. Veterinary Research 2009;40(6):60. https://doi.org/10.1051/vetres/2009043
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2008
Büttner Falk F. R., Maas Alexander, Gerlach Gerald-F.. An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Veterinary Microbiology 2008;127(1-2):106-115. https://doi.org/10.1016/j.vetmic.2007.08.005
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Büttner Falk F. R., Bendallah Ibrahim M., Bosse Janine T., Dreckmann Karla, Nash John H. E., Langford Paul R., Gerlach Gerald-F.. Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence. Infection and Immunity 2008;76(6):2284-2295. https://doi.org/10.1128/iai.01540-07
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2007
Baltes Nina, Büttner Falk F. R., Gerlach Gerald-F.. Selective capture of transcribed sequences (SCOTS) of Actinobacillus pleuropneumoniae in the chronic stage of disease reveals an HlyX-regulated autotransporter protein. Veterinary Microbiology 2007;123(1-3):110-121. https://doi.org/10.1016/j.vetmic.2007.03.026
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2005
Baltes Nina, N′diaye Mohamed, Jacobsen Ilse D., Maas Alexander, Büttner Falk F. R., Gerlach Gerald-F.. Deletion of the anaerobic regulator HlyX causes reduced colonization and persistence of Actinobacillus pleuropneumoniae in the porcine respiratory tract. Infection and Immunity 2005;73(8):4614-4619. https://doi.org/10.1128/iai.73.8.4614-4619.2005
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