Biochemistry and Molecular Biology

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Research - Molecular Cell Biology

Research Projects

Research focus:
  • Investigation of the molecular effect of extracellular vesicles (EV) on the development and progression of metabolic diseases such as obesity, type 2 diabetes and their comorbidities
  • Development of EV-based biomarkers for the clinical diagnosis of environmental diseases
  • Drug testing in pre-clinical disease models, including those for diabetic nephropathy

Methods:

  • Isolation and molecular characterization of EVs from tissues, cultured cells and body fluids using various methods such as differential ultracentrifugation, size exclusion chromatography, immunoprecipitation and nanoparticle tracking analysis (NTA)
  • Application of different techniques and models for the functional investigation of EVs
  • Use of cell biology-, biochemistry- and molecular biology-based approaches, including genetic modification of cells, polymerase chain reaction (PCR), western blot, enzyme-linked immunosorbent assay (ELISA), quantitative RNA and micro RNA analyses including RNA sequencing and single nuclei RNA sequencing
  • Performance of proteome analyses to investigate the protein composition of EVs
  • Application of microscopic techniques such as fluorescence microscopy, confocal microscopy and laser capture microdissection for the visualization and analysis of pathologies
  • Biomarker validation in clinical samples
  • Metabolic phenotyping in various pre-clinical models

 

Team Molecular Cell Biology

News

Feb. 7, 2024

New position paper on vesicle research released

The new position paper on the minimal information for studies of extracellular vesicles (MISEV) has been released. Our team member Konxhe Kulaj has made valuable contributions to the position paper as part of the MISEV Consortium. https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12404

Jan. 26, 2024

Doctorate successfully completed

Congratulations! Dr. rer. nat. Konxhe Kulaj has successfully defended her doctoral thesis "Adipocyte-derived Extracellular Vesicles in Metabolic Disease: Regulators of Insulin Secretion with Diagnostic Potential". Her research demonstrated that extracellular vesicles can enhance insulin secretion by delivering specific proteins to pancreatic beta cells. Additionally, her findings emphasize the promising role of these vesicles as diagnostic tools for metabolic diseases.

Jan. 24, 2024

Publication Award of the Faculty of Medicine

We are delighted to receive the 2023 Publication Award of the Faculty of Medicine! Our publication "Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo" was published in Nature Communications in February 2023 and investigates the influence of extracellular vesicles from adipose tissue on pancreatic insulin secretion.

Oct. 24, 2023

Invitation for a plenary talk at the MOVE international EV conference

Fantastic news! Our dedicated PhD student, Konxhe Kulaj, has been selected by the MOVE (MObility for Vesicles research in Europe) Consortium to give a plenary talk at their annual conference in Malaga. This presents a great opportunity for her to discuss her research with international experts in the field of extracellular vesicles.

Sept. 30, 2023

DZD international Research School

We take pride in the accomplishment of our PhD student, Sneha Prakash, who earned the opportunity to participate in the international Diabetes Research School organized by the German Center for Diabetes Research (DZD) in Hamburg. She presented her research project on diabetic nephropathy through a poster presentation addressing queries from esteemed experts in the field.

Feb. 1, 2023

Doctoral examination successfully passed

Hats off to Dr. rer. nat. Michaela Bauer for the successful defense of her doctoral thesis "The Role of Extracellular Vesicles in Metabolic Diseases." Her research centered on the characterisation of extracellular vesicles from adipocytes, studying their changes in obesity, and understanding their impact on metabolically active cells, especially pancreatic islet cells.

Jan. 18, 2023

New publication on the impact of adipocyte-derived EVs on insulin secretion released

In our recent article in Nature Communications we could demonstrate that extracellular vesicles from adipocytes influence insulin secretion. By transferring a specific cargo of proteins to pancreatic beta cells, vesicles from obese adipose tissue can enhance the secretion of insulin, contributing to the normalization of blood glucose levels.

Oct. 1, 2021

New premises for the Department of Molecular Cell Biology

The department of Molecular Cell Biology is moving into its new facilities! As we eagerly anticipate the completion of the new ITM research building at the Medical Campus of the University of Augsburg, our interim research labs at the Business Campus in Garching near Munich are fully operational, allowing us to continue our work seamlessly.

Open positions

 

Are you an ambitious scientist with a keen interest in the field of molecular cell biology? We are constantly seeking motivated students who are eager to undertake internships, Bachelor's and Master's theses, as well as medical doctorates in our laboratory. We offer high-level and multifaceted research projects, a stimulating, international working atmosphere and excellent training opportunities that encompass cutting-edge methodologies. Feel free  to get in touch with us!

 

 

© University of Augsburg

Publications

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006

2023
Glunk Viktoria, Laber Samantha, Sinnott-Armstrong Nasa, Sobreira Debora R., Strobel Sophie M., Batista Thiago M., Kubitz Phil, Moud Bahareh Nemati, Ebert Hannah, Huang Yi, Brandl Beate, Garbo Garrett, Honecker Julius, Stirling David R., Abdennur Nezar, Calabuig-Navarro Virtu, Skurk Thomas, Ocvirk Soeren, Stemmer Kerstin, Cimini Beth A., Carpenter Anne E., Dankel Simon N., Lindgren Cecilia M., Hauner Hans, Nobrega Marcelo A., Claussnitzer Melina. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nature Metabolism 2023;5(5):861-879. https://doi.org/10.1038/s42255-023-00807-w
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Kulaj Konxhe, Harger Alexandra, Bauer Michaela, Caliskan Özüm S., Gupta Tilak Kumar, Chiang Dapi Menglin, Milbank Edward, Reber Josefine, Karlas Angelos, Kotzbeck Petra, Sailer David N., Volta Francesco, Lutter Dominik, Prakash Sneha, Merl-Pham Juliane, Ntziachristos Vasilis, Hauner Hans, Pfaffl Michael W., Tschöp Matthias H., Müller Timo D., Hauck Stefanie M., Engel Benjamin D., Gerdes Jantje M., Pfluger Paul T., Krahmer Natalie, Stemmer Kerstin. Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo. Nature Communications 2023;14(1):709. https://doi.org/10.1038/s41467-023-36148-1
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Stemmer Kerstin, Müller Timo D.. GLP-1-Mimetika — wegweisend zur Behandlung von Diabetes und Adipositas. BIOspektrum 2023;29(2):137-139. https://doi.org/10.1007/s12268-023-1919-6
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Krause Christin, Britsemmer Jan H., Bernecker Miriam, Molenaar Anna, Taege Natalie, Geißler Cathleen, Kaehler Meike, Iben Katharina, Judycka Anna, Wagner Jonas, Wolter Stefan, Mann Oliver, Pfluger Paul T., Cascorbi Ingolf, Lehnert Hendrik, Stemmer Kerstin, Schriever Sonja C., Kirchner Henriette. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity. eLife 2023; https://doi.org/10.7554/eLife.92075.1
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Reviewed preprint

2022
Abuhattum Shada, Kotzbeck Petra, Schlüßler Raimund, Harger Alexandra, Ariza de Schellenberger Angela, Kim Kyoohyun, Escolano Joan-Carles, Müller Torsten, Braun Jürgen, Wabitsch Martin, Tschöp Matthias, Sack Ingolf, Brankatschk Marko, Guck Jochen, Stemmer Kerstin, Taubenberger Anna V.. Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens. Scientific Reports 2022;12(1):10325. https://doi.org/10.1038/s41598-022-13324-9
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Quarta Carmelo, Stemmer Kerstin, Novikoff Aaron, Yang Bin, Klingelhuber Felix, Harger Alex, Bakhti Mostafa, Bastidas-Ponce Aimee, Baugé Eric, Campbell Jonathan E., Capozzi Megan, Clemmensen Christoffer, Collden Gustav, Cota Perla, Douros Jon, Drucker Daniel J., DuBois Barent, Feuchtinger Annette, Garcia-Caceres Cristina, Grandl Gerald, Hennuyer Nathalie, Herzig Stephan, Hofmann Susanna M., Knerr Patrick J., Kulaj Konxhe, Lalloyer Fanny, Lickert Heiko, Liskiewicz Arek, Liskiewicz Daniela, Maity Gandhari, Perez-Tilve Diego, Prakash Sneha, Sanchez-Garrido Miguel A., Zhang Qian, Staels Bart, Krahmer Natalie, DiMarchi Richard D., Tschöp Matthias H., Finan Brian, Müller Timo D.. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism 2022;4(8):1071-1083. https://doi.org/10.1038/s42255-022-00617-6
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Evers Simon S., Shao Yikai, Ramakrishnan Sadeesh K., Shin Jae Hoon, Bozadjieva-Kramer Nadejda, Irmler Martin, Stemmer Kerstin, Sandoval Darleen A., Shah Yatrik M., Seeley Randy J.. Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion. Cell Reports 2022;38(3):110270. https://doi.org/10.1016/j.celrep.2021.110270
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2021
Aliluev Alexandra, Tritschler Sophie, Sterr Michael, Oppenländer Lena, Hinterdobler Julia, Greisle Tobias, Irmler Martin, Beckers Johannes, Sun Na, Walch Axel, Stemmer Kerstin, Kindt Alida, Krumsiek Jan, Tschöp Matthias H., Luecken Malte D., Theis Fabian J., Lickert Heiko, Böttcher Anika. Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice. Nature Metabolism 2021;3(9):1202-1216. https://doi.org/10.1038/s42255-021-00458-9
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Novikoff Aaron, O'Brien Shannon L., Bernecker Miriam, Grandl Gerald, Kleinert Maximilian, Knerr Patrick J., Stemmer Kerstin, Klingenspor Martin, Zeigerer Anja, DiMarchi Richard, Tschöp Matthias H., Finan Brian, Calebiro Davide, Müller Timo D.. Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists. Molecular Metabolism 2021;49. https://doi.org/10.1016/j.molmet.2021.101181
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Zhang Qian, Delessa Challa Tenagne, Augustin Robert, Bakhti Mostafa, Colldén Gustav, Drucker Daniel J., Feuchtinger Annette, Caceres Cristina Garcia, Grandl Gerald, Harger Alexandra, Herzig Stephan, Hofmann Susanna, Holleman Cassie Lynn, Jastroch Martin, Keipert Susanne, Kleinert Maximilian, Knerr Patrick J., Kulaj Konxhe, Legutko Beata, Lickert Heiko, Liu Xue, Luippold Gerd, Lutter Dominik, Malogajski Emilija, Medina Marta Tarquis, Mowery Stephanie A., Blutke Andreas, Perez-Tilve Diego, Salinno Ciro, Sehrer Laura, DiMarchi Richard D., Tschöp Matthias H., Stemmer Kerstin, Finan Brian, Wolfrum Christian, Müller Timo D.. The Glucose-dependent Insulinotropic Polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell Metabolism 2021;33(4):833-844.e5. https://doi.org/10.1016/j.cmet.2021.01.015
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Oppenländer Lena, Palit Subarna, Stemmer Kerstin, Greisle Tobias, Sterr Michael, Salinno Ciro, Bastidas-Ponce Aimée, Feuchtinger Annette, Böttcher Anika, Ansarullah , Theis Fabian J., Lickert Heiko. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Molecular Metabolism 2021;54. https://doi.org/10.1016/j.molmet.2021.101330
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2020
Stemmer Kerstin, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Müller Timo D.. Insights into incretin-based therapies for treatment of diabetic dyslipidemia. Advanced Drug Delivery Reviews 2020;159:34-53. https://doi.org/10.1016/j.addr.2020.05.008
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Jall Sigrid, De Angelis Meri, Lundsgaard Anne-Marie, Fritzen Andreas M., Nicolaisen Trine S., Klein Anders B., Novikoff Aaron, Sachs Stephan, Richter Erik A., Kiens Bente, Schramm Karl-Werner, Tschöp Matthias H., Stemmer Kerstin, Clemmensen Christoffer, Müller Timo D., Kleinert Maximilian. Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity. Diabetologia 2020;63(6):1236-1247. https://doi.org/10.1007/s00125-020-05117-4
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Sachs Stephan, Niu Lili, Geyer Philipp, Jall Sigrid, Kleinert Maximilian, Feuchtinger Annette, Stemmer Kerstin, Brielmeier Markus, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Wewer Albrechtsen Nicolai, Mann Matthias, Müller Timo D., Hofmann Susanna M.. Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice. Diabetes, Obesity and Metabolism 2020;23(1):195-207. https://doi.org/10.1111/dom.14215
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Fischer Katrin, Fenzl Anna, Liu Dianxin, Dyar Kenneth A., Kleinert Maximilian, Brielmeier Markus, Clemmensen Christoffer, Fedl Anna, Finan Brian, Gessner Andre, Jastroch Martin, Huang Jianfeng, Keipert Susanne, Klingenspor Martin, Brüning Jens C., Kneilling Manfred, Maier Florian C., Othman Ahmed E., Pichler Bernd J., Pramme-Steinwachs Ines, Sachs Stephan, Scheideler Angelika, Thaiss Wolfgang M., Uhlenhaut Henriette, Ussar Siegfried, Woods Stephen C., Zorn Julia, Stemmer Kerstin, Collins Sheila, Diaz-Meco Maria, Moscat Jorge, Tschöp Matthias H., Müller Timo D.. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nature Communications 2020;11(1). https://doi.org/10.1038/s41467-020-16230-8
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Schriever Sonja C., Kabra Dhiraj G., Pfuhlmann Katrin, Baumann Peter, Baumgart Emily V., Nagler Joachim, Seebacher Fabian, Harrison Luke, Irmler Martin, Kullmann Stephanie, Corrêa-da-Silva Felipe, Giesert Florian, Jain Ruchi, Schug Hannah, Castel Julien, Martinez Sarah, Wu Moya, Häring Hans-Ulrich, de Angelis Martin Hrabe, Beckers Johannes, Müller Timo D., Stemmer Kerstin, Wurst Wolfgang, Rozman Jan, Nogueiras Ruben, De Angelis Meri, Molkentin Jeffery D., Krahmer Natalie, Yi Chun-Xia, Schmidt Mathias V., Luquet Serge, Heni Martin, Tschöp Matthias H., Pfluger Paul T.. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. Journal of Clinical Investigation 2020;130(11):6093-6108. https://doi.org/10.1172/jci136363
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2019
Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Pfluger Paul T., Tschöp Matthias H.. CNS-targeting pharmacological interventions for the metabolic syndrome. Journal of Clinical Investigation 2019;129(10):4058-4071. https://doi.org/10.1172/jci129195
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Müller Günter A., Herling Andreas W., Stemmer Kerstin, Lechner Andreas, Tschöp Matthias H.. Chip-based sensing for release of unprocessed cell surface proteins in vitro and in serum and its (patho)physiological relevance. American Journal of Physiology-Endocrinology and Metabolism 2019;317(2):E212-E233. https://doi.org/10.1152/ajpendo.00079.2019
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Bastek Heinke, Zubel Tabea, Stemmer Kerstin, Mangerich Aswin, Beneke Sascha, Dietrich Daniel R.. Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. Toxicology 2019;420:29-38. https://doi.org/10.1016/j.tox.2019.03.013
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Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., Fritsche A., Gribble F., Grill H.J., Habener J.F., Holst J.J., Langhans W., Meier J.J., Nauck M.A., Perez-Tilve D., Pocai A., Reimann F., Sandoval D.A., Schwartz T.W., Seeley R.J., Stemmer Kerstin, Tang-Christensen M., Woods S.C., DiMarchi R.D., Tschöp M.H.. Glucagon-like peptide 1 (GLP-1). Molecular Metabolism 2019;30:72-130. https://doi.org/10.1016/j.molmet.2019.09.010
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Seitz Susanne, Kwon Yun, Hartleben Götz, Jülg Julia, Sekar Revathi, Krahmer Natalie, Najafi Bahar, Loft Anne, Gancheva Sofiya, Stemmer Kerstin, Feuchtinger Annette, Hrabe de Angelis Martin, Müller Timo D., Mann Matthias, Blüher Matthias, Roden Michael, Berriel Diaz Mauricio, Behrends Christian, Gilleron Jerome, Herzig Stephan, Zeigerer Anja. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nature Metabolism 2019;1(10):1009-1026. https://doi.org/10.1038/s42255-019-0124-x
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Harger A., Stemmer Kerstin, Tschöp M. H., Müller T. D.. Inkretinbasierte Ko- und Triagonisten: innovative Polypharmakologie zur Behandlung von Adipositas und Diabetes. Der Internist 2019;60(9):895-902. https://doi.org/10.1007/s00108-019-0649-9
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Niu Lili, Geyer Philipp E, Wewer Albrechtsen Nicolai J, Gluud Lise L, Santos Alberto, Doll Sophia, Treit Peter V, Holst Jens J, Knop Filip K, Vilsbøll Tina, Junker Anders, Sachs Stephan, Stemmer Kerstin, Müller Timo D, Tschöp Matthias H, Hofmann Susanna M, Mann Matthias. Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease. Molecular Systems Biology 2019;15(3):e8793. https://doi.org/10.15252/msb.20188793
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2018
Rahn Sascha, Zimmermann Vivien, Viol Fabrice, Knaack Hendrike, Stemmer Kerstin, Peters Lena, Lenk Lennart, Ungefroren Hendrik, Saur Dieter, Schäfer Heiner, Helm Ole, Sebens Susanne. Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells. Cancer Letters 2018;415:129-150. https://doi.org/10.1016/j.canlet.2017.12.004
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Brandt S. J., Müller T. D., DiMarchi R. D., Tschöp M. H., Stemmer Kerstin. Peptide-based multi-agonists: a new paradigm in metabolic pharmacology. Journal of Internal Medicine 2018;284(6):581-602. https://doi.org/10.1111/joim.12837
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2017
Ryan Karen K, Packard Amy E B, Larson Karlton R, Stout Jayna, Fourman Sarah M, Thompson Abigail M K, Ludwick Kristen, Habegger Kirk M, Stemmer Kerstin, Itoh Nobuyuki, Perez-Tilve Diego, Tschöp Matthias H, Seeley Randy J, Ulrich-Lai Yvonne M. Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21. Endocrinology 2017;159(1):400-413. https://doi.org/10.1210/en.2017-00486
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Pfuhlmann Katrin, Pfluger Paul T., Schriever Sonja C., Müller Timo D., Tschöp Matthias H., Stemmer Kerstin. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. PLOS ONE 2017;12(9):e0183488. https://doi.org/10.1371/journal.pone.0183488
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Kleinert Maximilian, Clemmensen Christoffer, Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Tschöp Matthias H.. Emerging poly-agonists for obesity and Type 2 Diabetes. Obesity 2017;25(10):1647-1649. https://doi.org/10.1002/oby.21932
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Giles Daniel A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Graspeuntner Simon, Cappelletti Monica, Wu David, Mukherjee Rajib, Chan Calvin C, Lawson Matthew J, Klarquist Jared, Sünderhauf Annika, Softic Samir, Kahn C Ronald, Stemmer Kerstin, Iwakura Yoichiro, Aronow Bruce J, Karns Rebekah, Steinbrecher Kris A, Karp Christopher L, Sheridan Rachel, Shanmukhappa Shiva K, Reynaud Damien, Haslam David B, Sina Christian, Rupp Jan, Hogan Simon P, Divanovic Senad. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nature Medicine 2017;23(7):829-838. https://doi.org/10.1038/nm.4346
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Erratum: Nature Medicine 23, 1241 (2017), DOI 10.1038/nm1017-1241c
Klaus Valentina, Bastek Heinke, Damme Katja, Collins Leonard B., Frötschl Roland, Benda Norbert, Lutter Dominik, Ellinger-Ziegelbauer Heidrun, Swenberg James A., Dietrich Daniel R., Stemmer Kerstin. Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats. Archives of Toxicology 2017;91(10):3427-3438. https://doi.org/10.1007/s00204-017-1953-6
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2016
Maida Adriano, Zota Annika, Sjøberg Kim A., Schumacher Jonas, Sijmonsma Tjeerd P., Pfenninger Anja, Christensen Marie M., Gantert Thomas, Fuhrmeister Jessica, Rothermel Ulrike, Schmoll Dieter, Heikenwälder Mathias, Iovanna Juan L., Stemmer Kerstin, Kiens Bente, Herzig Stephan, Rose Adam J.. A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution. Journal of Clinical Investigation 2016;126(9):3263-3278. https://doi.org/10.1172/jci85946
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Finan Brian, Clemmensen Christoffer, Zhu Zhimeng, Stemmer Kerstin, Gauthier Karine, Müller Luisa, De Angelis Meri, Moreth Kristin, Neff Frauke, Perez-Tilve Diego, Fischer Katrin, Lutter Dominik, Sánchez-Garrido Miguel A., Liu Peng, Tuckermann Jan, Malehmir Mohsen, Healy Marc E., Weber Achim, Heikenwalder Mathias, Jastroch Martin, Kleinert Maximilian, Jall Sigrid, Brandt Sara, Flamant Frédéric, Schramm Karl-Werner, Biebermann Heike, Döring Yvonne, Weber Christian, Habegger Kirk M., Keuper Michaela, Gelfanov Vasily, Liu Fa, Köhrle Josef, Rozman Jan, Fuchs Helmut, Gailus-Durner Valerie, Hrabě de Angelis Martin, Hofmann Susanna M., Yang Bin, Tschöp Matthias H., DiMarchi Richard, Müller Timo D.. Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease. Cell 2016;167(3):843-857.e14. https://doi.org/10.1016/j.cell.2016.09.014
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Kabra Dhiraj G., Pfuhlmann Katrin, García-Cáceres Cristina, Schriever Sonja C., Casquero García Veronica, Kebede Adam Fiseha, Fuente-Martin Esther, Trivedi Chitrang, Heppner Kristy, Uhlenhaut N. Henriette, Legutko Beata, Kabra Uma D., Gao Yuanqing, Yi Chun-Xia, Quarta Carmelo, Clemmensen Christoffer, Finan Brian, Müller Timo D., Meyer Carola W., Paez-Pereda Marcelo, Stemmer Kerstin, Woods Stephen C., Perez-Tilve Diego, Schneider Robert, Olson Eric N., Tschöp Matthias H., Pfluger Paul T.. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature Communications 2016;7(1):10782. https://doi.org/10.1038/ncomms10782
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2015
Stemmer Kerstin, Zani Fabio, Habegger Kirk M., Neff Christina, Kotzbeck Petra, Bauer Michaela, Yalamanchilli Suma, Azad Ali, Lehti Maarit, Martins Paulo J. F., Müller Timo D., Pfluger Paul T., Seeley Randy J.. FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice. Diabetologia 2015;58(10):2414-2423. https://doi.org/10.1007/s00125-015-3668-7
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Dargel Christina, Bassani-Sternberg Michal, Hasreiter Julia, Zani Fabio, Bockmann Jan-Hendrik, Thiele Frank, Bohne Felix, Wisskirchen Karin, Wilde Susanne, Sprinzl Martin F., Schendel Dolores J., Krackhardt Angela M., Uckert Wolfgang, Wohlleber Dirk, Schiemann Matthias, Stemmer Kerstin, Heikenwälder Mathias, Busch Dirk H., Richter Günther, Mann Matthias, Protzer Ulrike. T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice. Gastroenterology 2015;149(4):1042-1052. https://doi.org/10.1053/j.gastro.2015.05.055
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2014
Wolf Monika Julia, Adili Arlind, Piotrowitz Kira, Abdullah Zeinab, Boege Yannick, Stemmer Kerstin, Ringelhan Marc, Simonavicius Nicole, Egger Michèle, Wohlleber Dirk, Lorentzen Anna, Einer Claudia, Schulz Sabine, Clavel Thomas, Protzer Ulrike, Thiele Christoph, Zischka Hans, Moch Holger, Tschöp Matthias, Tumanov Alexei V., Haller Dirk, Unger Kristian, Karin Michael, Kopf Manfred, Knolle Percy, Weber Achim, Heikenwalder Mathias. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 2014;26(4):549-564. https://doi.org/10.1016/j.ccell.2014.09.003
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Brockmann Anette, Strittmatter Tobias, May Sarah, Stemmer Kerstin, Marx Andreas, Brunner Thomas. Structure–function relationship of thiazolide-induced apoptosis in colorectal tumor cells. ACS Chemical Biology 2014;9(7):1520-1527. https://doi.org/10.1021/cb500209a
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Stemmer Kerstin, Kotzbeck P, Zani F, Bauer M, Neff C, Müller T D, Pfluger P T, Seeley R J, Divanovic S. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. International Journal of Obesity 2014;39(5):791-797. https://doi.org/10.1038/ijo.2014.187
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2013
Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. Regulatory Toxicology and Pharmacology 2013;67(3):317-320. https://doi.org/10.1016/j.yrtph.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. Food and Chemical Toxicology 2013;62:A1-A4. https://doi.org/10.1016/j.fct.2013.07.005
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Habegger K. M., Stemmer Kerstin, Cheng C., Muller T. D., Heppner K. M., Ottaway N., Holland J., Hembree J. L., Smiley D., Gelfanov V., Krishna R., Arafat A. M., Konkar A., Belli S., Kapps M., Woods S. C., Hofmann S. M., D'Alessio D., Pfluger P. T., Perez-Tilve D., Seeley R. J., Konishi M., Itoh N., Kharitonenkov A., Spranger J., DiMarchi R. D., Tschop M. H.. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes 2013;62(5):1453-1463. https://doi.org/10.2337/db12-1116
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Bielohuby Maximilian, Sisley Stephanie, Sandoval Darleen, Herbach Nadja, Zengin Ayse, Fischereder Michael, Menhofer Dominik, Stoehr Barbara J. M., Stemmer Kerstin, Wanke Rüdiger, Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. American Journal of Physiology-Endocrinology and Metabolism 2013;305(9):E1059-E1070. https://doi.org/10.1152/ajpendo.00208.2013
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Dietrich Daniel, von Aulock Sonja, Marquardt H. W. J., Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan G., Collier Abby C., Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Open letter to the European commission: scientifically unfounded precaution drives European commission’s recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles. Archives of Toxicology 2013;87(9):1739-1741. https://doi.org/10.1007/s00204-013-1117-2
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Stemmer Kerstin, Bielohuby Maximilian, Grayson Bernadette E., Begg Denovan P., Chambers Adam P., Neff Christina, Woods Stephen C., Erben Reinhold G., Tschöp Matthias H., Bidlingmaier Martin, Clemens Thomas L., Seeley Randy J.. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology 2013;154(6):2015-2024. https://doi.org/10.1210/en.2012-2130
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan, Barile Frank A.. Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicon 2013;76:A1-A2. https://doi.org/10.1016/j.toxicon.2013.10.020
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Barile Frank A., Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Chemico-Biological Interactions 2013;205(1):A1-A5. https://doi.org/10.1016/j.cbi.2013.07.001
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Wallace Hayes A., Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicology in Vitro 2013;27(7):2110-2114. https://doi.org/10.1016/j.tiv.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. ALTEX 2013;30(3):381-385. https://doi.org/10.14573/altex.2013.3.381
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Müller Timo D., Müller Anne, Yi Chun-Xia, M Habegger Kirk, Meyer Carola W., Gaylinn Bruce D., Finan Brian, Heppner Kristy, Trivedi Chitrang, Bielohuby Maximilian, Abplanalp William, Meyer Franziska, Piechowski Carolin L., Pratzka Juliane, Stemmer Kerstin, Holland Jenna, Hembree Jazzmin, Bhardwaj Nakul, Raver Christine, Ottaway Nickki, Krishna Radha, Sah Renu, Sallee Floyd R., Woods Stephen C., Perez-Tilve Diego, Bidlingmaier Martin, Thorner Michael O., Krude Heiko, Smiley David, DiMarchi Richard, Hofmann Susanna, Pfluger Paul T., Kleinau Gunnar, Biebermann Heike, Tschöp Matthias H.. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature Communications 2013;4(1):1968. https://doi.org/10.1038/ncomms2968
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2012
Stemmer Kerstin, Perez-Tilve Diego, Ananthakrishnan Gayathri, Bort Anja, Seeley Randy J., Tschöp Matthias H., Dietrich Daniel R., Pfluger Paul T.. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Disease Models and Mechanisms 2012;5(5):627-635. https://doi.org/10.1242/dmm.009407
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Okle Oliver, Stemmer Kerstin, Deschl Ulrich, Dietrich Daniel R.. L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations. Toxicological Sciences 2012;131(1):217-224. https://doi.org/10.1093/toxsci/kfs291
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Finan Brian, Yang Bin, Ottaway Nickki, Stemmer Kerstin, Müller Timo D, Yi Chun-Xia, Habegger Kirk, Schriever Sonja C, García-Cáceres Cristina, Kabra Dhiraj G, Hembree Jazzminn, Holland Jenna, Raver Christine, Seeley Randy J, Hans Wolfgang, Irmler Martin, Beckers Johannes, de Angelis Martin Hrabě, Tiano Joseph P, Mauvais-Jarvis Franck, Perez-Tilve Diego, Pfluger Paul, Zhang Lianshan, Gelfanov Vasily, DiMarchi Richard D, Tschöp Matthias H. Targeted estrogen delivery reverses the metabolic syndrome. Nature Medicine 2012;18(12):1847-1856. https://doi.org/10.1038/nm.3009
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Müller Timo D., Lee Sang Jun, Jastroch Martin, Kabra Dhiraj, Stemmer Kerstin, Aichler Michaela, Abplanalp Bill, Ananthakrishnan Gayathri, Bhardwaj Nakul, Collins Sheila, Divanovic Senad, Endele Max, Finan Brian, Gao Yuanqing, Habegger Kirk M., Hembree Jazzmin, Heppner Kristy M., Hofmann Susanna, Holland Jenna, Küchler Daniela, Kutschke Maria, Krishna Radha, Lehti Maarit, Oelkrug Rebecca, Ottaway Nickki, Perez-Tilve Diego, Raver Christine, Walch Axel K., Schriever Sonja C., Speakman John, Tseng Yu-Hua, Diaz-Meco Maria, Pfluger Paul T., Moscat Jorge, Tschöp Matthias H.. p62 Links β-adrenergic input to mitochondrial function and thermogenesis. Journal of Clinical Investigation 2012;123(1):469-478. https://doi.org/10.1172/jci64209
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2011
Stemmer Kerstin, Dietrich Daniel R.. Application of laser-capture microdissection to study renal carcinogenesis. In: Murray Graeme I., editor. Laser capture microdissection. Totowa, NJ: Humana Press; 2011. p. 279-290. https://doi.org/10.1007/978-1-61779-163-5_23
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Bielohuby Maximilian, Stemmer Kerstin, Berger José, Ramisch Juliane, Smith Kathleen, Holland Jenna, Parks Kenneth, Pfluger Paul T., Habegger Kirk M., Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obesity Surgery 2011;22(1):140-151. https://doi.org/10.1007/s11695-011-0528-5
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Feurstein Daniel, Stemmer Kerstin, Kleinteich Julia, Speicher Tobias, Dietrich Daniel R. Microcystin congener– and concentration-dependent induction of murine neuron apoptosis and neurite degeneration. Toxicological Sciences 2011;124(2):424-431. https://doi.org/10.1093/toxsci/kfr243
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2010
Bielohuby Maximilian, Menhofer Dominik, Kirchner Henriette, Stoehr Barbara J. M., Müller Timo D., Stock Peggy, Hempel Madlen, Stemmer Kerstin, Pfluger Paul T., Kienzle Ellen, Christ Bruno, Tschöp Matthias H., Bidlingmaier Martin. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. American Journal of Physiology: Endocrinology and Metabolism 2010;300(1):E65-E76. https://doi.org/10.1152/ajpendo.00478.2010
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Feurstein Daniel, Kleinteich Julia, Heussner Alexandra H., Stemmer Kerstin, Dietrich Daniel R.. Investigation of microcystin congener–dependent uptake into primary murine neurons. Environmental Health Perspectives 2010;118(10):1370-1375. https://doi.org/10.1289/ehp.0901289
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Fischer A., Hoeger S.J., Stemmer Kerstin, Feurstein D.J., Knobeloch D., Nussler A., Dietrich D.R.. The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells. Toxicology and Applied Pharmacology 2010;245(1):9-20. https://doi.org/10.1016/j.taap.2010.02.006
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2009
Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Jürgen, Dietrich Daniel R.. Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors. The American Journal of Pathology 2009;175(4):1686-1698. https://doi.org/10.2353/ajpath.2009.081071
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2007
Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Juergen, Dietrich Daniel R.. Carcinogen-specific gene expression profiles in short-term treated eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer Research 2007;67(9):4052-4068. https://doi.org/10.1158/0008-5472.can-06-3587
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2006
Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Lotz Kerstin, Ahr Hans-J., Dietrich Daniel R.. Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips. Toxicology and Applied Pharmacology 2006;217(1):134-142. https://doi.org/10.1016/j.taap.2006.07.012
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