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2025

Hillenbrand Caroline A., Akbari Bani Dorssa, Follonier Océane, Kaur Amandeep, Weissbach Fabian H., Wernli Marion, Wilhelm Maud, Leuzinger Karoline, Binet Isabelle, Bochud Pierre-Yves, Golshayan Dela, Hirzel Cédric, Manuel Oriol, Mueller Nicolas J., Schaub Stefan, Schachtner Thomas, Van Delden Christian, Hirsch Hans H., Amico Patrizia, Bachofner Adrian, Banz Vanessa, Beckmann Sonja, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Berzigotti Annalisa, Binet Françoise-Isabelle, Bochud Pierre-Yves, Borner Petra, Branca Sanda, Cairoli Anne, Catana Emmanuelle, Chalandon Yves, Compagnon Philippe, De Geest Sabina, De Seigneux Sophie, Dickenmann Michael, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Flammer Andreas, Frossard Jaromil, Golshayan Dela, Goossens Nicolas, Haidar Fadi, Halter Jürg, Hess Christoph, Hillinger Sven, Hirsch Hans H., Hirt Patricia, Hoessly Linard, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Khanna Nina, Koller Michael, Kremer Andreas, Krueger Thorsten, Kuhn Christian, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, L'Huillier Arnaud, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Merçay Aurélia, Mettler Karin, Müller Nicolas, Müller Jelena, Müller-Arndt Ulrike, Nägeli Mirjam, Neofytos Dionysios, Nilsson Jakob, Pascual Manuel, Pazeller Rosmarie, Reineke David, Rick Juliane, Rössler Fabian, Rothlin Silvia, Schachtner Thomas, Schaub Stefan, Schneidawind Dominik, Schuurmans Macé, Schwab Simon, Sengstag Thierry, Sidler Daniel, Simonetta Federico, Steiger Jürg, Stirnimann Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wehmeier Caroline, Wilhelm Markus, Yerly Patrick. BK polyomavirus serotype-specific antibody responses in blood donors and kidney transplant recipients with and without new-onset BK polyomavirus-DNAemia: a Swiss Transplant Cohort Study. American Journal of Transplantation 2025;25(5):985-1001. https://doi.org/10.1016/j.ajt.2024.11.019 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Hoessly Linard, Schwab Simon, Chammartin Frédérique, Leichtle Alexander, Schreiber Peter Werner, Neofytos Dionysios, Frossard Jaromil, Koller Michael. COVERAGE - comparing variable and feature selection strategies for prediction - protocol of a simulation study in low-dimensional transplantation data [Study protocol]. OSF Registries (Online-Ressource). Charlottesville, VA: Center for Open Science; 2025. BibTeX | RIS | URL

Hoessly Linard, Frossard Jaromil, Schwab Simon, Chammartin Frédérique, Leichtle Alexander, Schreiber Peter W., Neofytos Dionysios, Koller Michael. Comparing variable and feature selection strategies for prediction - protocol of a simulation study in low-dimensional transplantation data. PLoS One 2025;20(8):e0328696. https://doi.org/10.1371/journal.pone.0328696 PDF | BibTeX | RIS | DOI

Schär David, Blatter Tobias U., Witte Harald, Stoyanov Jivko, Hersberger Martin, Nakas Christos T., Leichtle Alexander B.. Differential distributions: a refined methodology to indirect reference interval estimation by including patient's health status according to associated ICD-10 codes. Practical Laboratory Medicine 2025;46:e00492. https://doi.org/10.1016/j.plabm.2025.e00492 PDF | BibTeX | RIS | DOI

Fan Bowen, Schürch Manuel, Tian Yuan, Mallone Anna, Frischknecht Lukas, Koller Michael, Van Delden Christian, Leichtle Alexander, Golshayan Dela, Villard Jean, Schachtner Thomas, Sidler Daniel, Schaub Stefan, Nilsson Jakob, Krauthammer Michael. Enhancing post-kidney transplant prognostication: an interpretable machine learning approach for longitudinal outcome prediction. preprint; 2025. https://doi.org/10.2139/ssrn.5235055 BibTeX | RIS | DOI

Meyer Lilly, Frossard Jaromil, Schreiber Peter W., Manuel Oriol, Lamoth Frederic, Khanna Nina, Boggian Katia, Walti Laura, Garzoni Christian, van Delden Christian, Mueller Nicolas J., Neofytos Dionysios. Invasive Candida infections in solid organ transplant recipients between 2008 and 2020. American Journal of Transplantation 2025; https://doi.org/10.1016/j.ajt.2025.07.2480 BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Wohlfender Martin S., Bouman Judith A., Endrich Olga, Ramette Alban, Leichtle Alexander B., Beldi Guido, Althaus Christian L., Riou Julien. Machine learning-based short-term forecasting of COVID-19 hospital admissions using routine hospital patient data. preprint; 2025. https://doi.org/10.1101/2025.05.21.25328056 BibTeX | RIS | DOI

Halfon Matthieu, Taffé Patrick, Bucher Christian, Haidar Fadi, Huynh-do Uyen, Mani Laila-Yasmin, Schachtner Thomas, Wehmeier Caroline, Venetz Jean-Pierre, Pascual Manuel, Fakhouri Fadi, Golshayan Dela, Amico Patrizia, Aubert John-David, Banz Vanessa, Beckmann Sonia, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Catana Emmanuelle, Chalandon Yves, De Geest Sabina, De Seigneux Michael Dickenmann Sophie, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Garzoni Christian, Gaudet Christophe, Golshayan Déla, Goossens Nicolas, Halter Jörg, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans H., Hirt Patricia, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Laager Mirjam, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Mercay Aurelia, Mettler Karin, Mueller Nicolas J., Müller Antonia, Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Passweg Jakob, Posfay-Barbe Klara, Rick Juliane, Rosselet Anne, Rossi Simona, Rothlin Silvia, Ruschitzka Frank, Schachtner Thomas, Schanz Urs, Schaub Stefan, Schwab Simon, Schnyder Aurelia, Schuurmans Macé, Sengstag Thierry, Simonetta Federico, Steiger Jürg, Stirniman Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhlem Markus, Yerly Patrick. Outcome of patients transplanted for C3 glomerulopathy and primary immune complex-mediated membranoproliferative glomerulonephritis. Kidney International Reports 2025;10(1):75-86. https://doi.org/10.1016/j.ekir.2024.10.008 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Abawi Ozair, Sommer Grit, Grössl Michael, Halbsguth Ulrike, du Toit Therina, Hannema Sabine E., de Bruin Christiaan, Charmandari Evangelia, van den Akker Erica L. T., Leichtle Alexander B., Flück Christa E.. Predicting treatment outcome in congenital adrenal hyperplasia using urine steroidomics and machine learning. European Journal of Endocrinology 2025;193(1):10-20. https://doi.org/10.1093/ejendo/lvaf121 BibTeX | RIS | DOI

Manigold Tobias, Leichtle Alexander. Predominance of calcium pyrophosphate crystals in synovial fluid samples of patients at a large tertiary center. Diagnostics 2025;15(7):907. https://doi.org/10.3390/diagnostics15070907 PDF | BibTeX | RIS | DOI

Bocchi Federica, Müller Selina, Binet Isabelle, Golshayan Dela, Haidar Fadi, Müller Thomas, Schaub Stefan, Schnyder Aurelia, Sidler Daniel, Storni Federico, Amico Patrizia, Bachofner Adrian, Banz Vanessa, Beckmann Sonja, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Berzigotti Annalisa, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Cairoli Anne, Catana Emmanuelle, Chalandon Yves, De Geest Sabina, De Seigneux Sophie, Dickenmann Michael, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Frossard Jaromil, Garzoni Christian, Golshayan Déla, Goossens Nicolas, Haidar Fadi, Halter Jörg, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans, Hirt Patricia, Hoessly Linard, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Kremer Andreas, Krueger Thorsten, Kuhn Christian, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Merçay Aurélia, Mettler Karin, Müller Nicolas, Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Passweg Jakob, Pazeller Rosemarie, Posfay-Barbe Klara, Reineke David, Rick Juliane, Rosselet Anne, Rossi Simona, Rössler , Rothlin Silvia, Ruschitzka Frank, Schachtner Thomas, Schaub Stefan, Scherrer Alexandra, Schneidawind Dominik, Schnyder Aurelia, Schuurmans Macé, Schwab Simon, Sengstag Thierry, Simonetta Federico, Steiger Jürg, Stirniman Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhlem Markus, Yerly Patrick. Reintegration into the workforce after kidney transplantation based on urbanization status in Switzerland. Kidney International Reports 2025;10(2):565-573. https://doi.org/10.1016/j.ekir.2024.10.029 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Schreiber Peter W., Hoessly Linard D., Boggian Katia, Neofytos Dionysios, van Delden Christian, Egli Adrian, Dickenmann Michael, Hirzel Cédric, Manuel Oriol, Koller Michael, Rossi Simona, Banz Vanessa, Compagnon Philippe, Dutkowski Philipp, Kremer Andreas E., Berzigotti Annalisa, Vionnet Julien, Goossens Nicolas, Semela David, Künzler-Heule Patrizia, Bernsmeier Christine, Kuster Stefan P., Stampf Susanne, Mueller Nicolas J., Amico Patrizia, Bachofner Adrian, Banz Vanessa, Beckmann Sonja, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Berzigotti Annalisa, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Cairoli Anne, Catana Emmanuelle, Chalandon Yves, De Geest Sabina, De Seigneux Sophie, Dreifuss Joëlle L, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Frossard Jaromil, Golshayan Déla, Goossens Nicolas, Haidar Fadi, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans H, Hirt Patricia, Hoessly Linard, Hofbauer Günther, Huynh-Do Uyen, Khanna Nina, Koller Michael, Kremer Andreas, Krueger Thorsten, Kuhn Christian, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Mercay Aurélia, Mettler Karin, Müller Nicolas, Müller-Arndt Ulrike, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Pazeller Rosemarie, Posfay-Barbe Klara, Reineke David, Rick Juliane, Rossi Simona, Rössler Fabian, Rothlin Silvia, Ruschitzka Frank, Schachtner Thomas, Schaub Stefan, Schneidawind Dominik, Schuurmans Macé, Schwab Simon, Sengstag Thierry, Simonetta Frederico, Steiger Jürg, Stirniman Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wehmeier Caroline, Wick Madeleine, Wilhelm Markus, Yerly Patrick. Surgical site infections, risk factors, and outcomes after liver transplant. JAMA Network Open 2025;8(3):e251333. https://doi.org/10.1001/jamanetworkopen.2025.1333 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

2024

Blatter Tobias U., Schär David, Witte Harald, Nakas Christos T., Leichtle Alexander B.. Data mining reference intervals by ICD-10 stratified differential distributions [Letter]. Clinical Chemistry 2024;70(9):1182-1184. https://doi.org/10.1093/clinchem/hvae089 PDF | BibTeX | RIS | DOI

Blatter Tobias U., Nakas Christos T., Leichtle Alexander Benedikt. Direct, age- and gender-specific reference intervals: applying a modified M-estimator of the Yeo-Johnson transformation to clinical real-world data. Journal of Laboratory Medicine 2024;48(5):239-250. https://doi.org/10.1515/labmed-2024-0076 PDF | BibTeX | RIS | DOI

Brune Jakob E., Dickenmann Michael, Sidler Daniel, Walti Laura N., Golshayan Déla, Manuel Oriol, Haidar Fadi, Neofytos Dionysios, Schnyder Aurelia, Boggian Katia, Mueller Thomas F., Schachtner Thomas, Khanna Nina, Schaub Stefan, Wehmeier Caroline. Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Frontiers in Medicine 2024;11:1329778. https://doi.org/10.3389/fmed.2024.1329778 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Manigold T., Leichtle Alexander B.. OP0191 Dominating prevalence of calciumpyrophosphat (CPP) crystals among inflammatory synovial fluid samples in an unbiased analysis at the largest Swiss tertiary center [Abstract]. Annals of the Rheumatic Diseases 2024;83(Supplement 1):91. https://doi.org/10.1136/annrheumdis-2024-eular.4031 BibTeX | RIS | DOI

Pradervand S., Freundler N., Gosztonyi B., Roncoroni L., Achermann R., Schwenk T., de Fraipont G., Garessus J., Haefliger S., Leichtle Alexander B., Kiessling M. K., Mueller-Focke T., Krebs F. S., Zoete V., Tsantoulis P., Michielin O., Britschgi C., Wicki A.. Real-world occurrence, therapy, and outcome of patients with class 2 or 3 BRAF compared with class 1 BRAF-mutated cancers. ESMO Real World Data and Digital Oncology 2024;6:100075. https://doi.org/10.1016/j.esmorw.2024.100075 PDF | BibTeX | RIS | DOI

Schreiber Peter W., Hoessly Linard D., Boggian Katia, Neofytos Dionysios, van Delden Christian, Egli Adrian, Dickenmann Michael, Hirzel Cédric, Manuel Oriol, Koller Michael, Rossi Simona, Banz Vanessa, Schmied Bruno, Guerke Lorenz, Matter Maurice, de Rougemont Olivier, Bonani Marco, Golshayan Déla, Schnyder Aurelia, Sidler Daniel, Haidar Fadi, Kuster Stefan P., Stampf Susanne, Mueller Nicolas J., Amico Patrizia, Aubert John-David, Banz Vanessa, Beckmann Sonja, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Berzigotti Annalisa, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Catana Emmanuelle, Cairoli Anne, Chalandon Yves, De Geest Sabina, De Rougemont Olivier, De Seigneux Sophie, Dickenmann Michael, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Garzoni Christian, Golshayan Déla, Goossens Nicolas, Haidar Fadi, Halter Jörg, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans H., Hirt Patricia, Hoessly Linard, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Merçay Aurélia, Mettler Karin, Mueller Nicolas J., Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Passweg Jakob, Pazeller Rosemarie, Posfay-Barbe Klara, Rick Juliane, Rosselet Anne, Rossi Simona, Rothlin Silvia, Ruschitzka Frank, Schachtner Thomas, Schaub Stefan, Scherrer Alexandra, Schnyder Aurelia, Schuurmans Macé, Schwab Simon, Sengstag Thierry, Simonetta Federico, Stampf Susanne, Steiger Jürg, Stirnimann Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhelm Markus, Yerly Patrick. Surgical site infections after kidney transplantation are independently associated with graft loss. American Journal of Transplantation 2024;24(5):795-802. https://doi.org/10.1016/j.ajt.2023.11.013 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study (STCS). Please see publisher's website for further details.

2023

Nagabhushana Priyanka, Rütsche Cyrill, Nakas Christos, Leichtle Alexander B.. Deployment of an automated Method Verification-Graphical User Interface (MV-GUI) software. BioMedInformatics 2023;3(3):632-648. https://doi.org/10.3390/biomedinformatics3030043 PDF | BibTeX | RIS | DOI

de Rougemont Olivier, Deng Yun, Frischknecht Lukas, Wehmeier Caroline, Villard Jean, Ferrari-Lacraz Sylvie, Golshayan Déla, Gannagé Monique, Binet Isabelle, Wirthmueller Urs, Sidler Daniel, Schachtner Thomas, Schaub Stefan, Nilsson Jakob. Donation type and the effect of pre-transplant donor specific antibodies – data from the Swiss Transplant Cohort Study. Frontiers in Immunology 2023;14:1104371. https://doi.org/10.3389/fimmu.2023.1104371 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Atkinson Andrew, Ellenberger Benjamin, Piezzi Vanja, Kaspar Tanja, Salazar-Vizcaya Luisa, Endrich Olga, Leichtle Alexander B., Marschall Jonas. Extending outbreak investigation with machine learning and graph theory: benefits of new tools with application to a nosocomial outbreak of a multidrug-resistant organism. Infection Control und Hospital Epidemiology 2023;44(2):246-252. https://doi.org/10.1017/ice.2022.66 PDF | BibTeX | RIS | DOI

Sokollik Christiane, Pahud de Mortanges Aurélie, Leichtle Alexander B., Juillerat Pascal, Horn Michael P.. Machine learning in antibody diagnostics for inflammatory bowel disease subtype classification. Diagnostics 2023;13(15):2491. https://doi.org/10.3390/diagnostics13152491 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss IBD Cohort Study Group. Please see publisher's website for further details.

Mottin Luc, Goldman Jean-Philippe, Jäggli Christoph, Achermann Rita, Gobeill Julien, Knafou Julien, Ehrsam Julien, Wicky Alexandre, Gérard Camille L., Schwenk Tanja, Charrier Mélinda, Tsantoulis Petros, Lovis Christian, Leichtle Alexander, Kiessling Michael K., Michielin Olivier, Pradervand Sylvain, Foufi Vasiliki, Ruch Patrick. Multilingual RECIST classification of radiology reports using supervised learning. Frontiers in Digital Health 2023;5:1195017. https://doi.org/10.3389/fdgth.2023.1195017 PDF | BibTeX | RIS | DOI

Buttia Chepkoech, Llanaj Erand, Raeisi-Dehkordi Hamidreza, Kastrati Lum, Amiri Mojgan, Meçani Renald, Taneri Petek Eylul, Gómez Ochoa Sergio Alejandro, Raguindin Peter Francis, Wehrli Faina, Khatami Farnaz, Espínola Octavio Pano, Rojas Lyda Z., Pahud de Mortanges Aurélie, Macharia-Nimietz Eric Francis, Alijla Fadi, Minder Beatrice, Leichtle Alexander B., Lüthi Nora, Ehrhard Simone, Que Yok-Ai, Kopp Fernandes Laurenz, Hautz Wolf, Muka Taulant. Prognostic models in COVID-19 infection that predict severity: a systematic review. European Journal of Epidemiology 2023;38(4):355-372. https://doi.org/10.1007/s10654-023-00973-x PDF | BibTeX | RIS | DOI

Wittwer Marco Fabian, Kim Soung-Yung, Leichtle Alexander, Berezowska Sabina, Guler Sabina A., Geiser Thomas, Heverhagen Johannes, Maurer Britta, Poellinger Alexander. Signs of alveolar collapse in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and systemic sclerosis revealed by inspiration and expiration computed tomography. BioMed 2023;3(4):471-483. https://doi.org/10.3390/biomed3040038 PDF | BibTeX | RIS | DOI

Witte Harald, Blatter Tobias U., Nagabhushana Priyanka, Schär David, Ackermann James, Cadamuro Janne, Leichtle Alexander B.. Statistical learning and big data applications. Journal of Laboratory Medicine 2023;47(4):181-186. https://doi.org/10.1515/labmed-2023-0037 PDF | BibTeX | RIS | DOI

Abawi Ozair, Sommer Grit, Groessl Michael, Halbsguth Ulrike, Hannema Sabine E., de Bruin Christiaan, Charmandari Evangelia, van den Akker Erica L. T., Leichtle Alexander B., Flueck Christa E.. THU208 Predicting treatment quality assessment of children with congenital adrenal hyperplasia using 24h urine metabolomics profiling and a machine learning-assisted approach [Abstract]. Journal of the Endocrine Society 2023;7(Supplement_1):bvad114.1459. https://doi.org/10.1210/jendso/bvad114.1459 PDF | BibTeX | RIS | DOI

Blatter Tobias Ueli, Witte Harald, Fasquelle-Lopez Jules, Nakas Christos Theodoros, Raisaro Jean Louis, Leichtle Alexander Benedikt. The BioRef infrastructure, a framework for real-time, federated, privacy-preserving, and personalized reference intervals: design, development, and application. Journal of Medical Internet Research 2023;25:e47254. https://doi.org/10.2196/47254 PDF | BibTeX | RIS | DOI

Walti Laura N., Mugglin Catrina, Mombelli Matteo, Manuel Oriol, Hirsch Hans H., Khanna Nina, Mueller Nicolas J., Berger Christoph, Boggian Katia, Garzoni Christian, Neofytos Dionysios, van Delden Christian, Mäusezahl Mirjam, Hirzel Cédric. Vaccine-preventable infections among solid organ transplant recipients in Switzerland. JAMA Network Open 2023;6(4):e2310687. https://doi.org/10.1001/jamanetworkopen.2023.10687 PDF | BibTeX | RIS | DOI Published for the Swiss Transplant Cohort Study. Please see publisher's website for further details.

2022

Atkinson A., Ellenberger B., Piezzi V., Kaspar T., Endrich O., Leichtle Alexander B., Zwahlen M., Marschall J.. A Bayesian spatiotemporal model for prevalence estimation of a VRE outbreak in a tertiary care hospital. Journal of Hospital Infection 2022;122:108-114. https://doi.org/10.1016/j.jhin.2021.12.024 PDF | BibTeX | RIS | DOI

Beckmann Sonja, Mauthner Oliver, Schick Liz, Rochat Jessica, Lovis Christian, Boehler Annette, Binet Isabelle, Huynh-Do Uyen, De Geest Sabina. A national survey comparing patients' and transplant professionals' research priorities in the Swiss Transplant Cohort Study. Transplant International 2022;35:10255. https://doi.org/10.3389/ti.2022.10255 PDF | BibTeX | RIS | DOI Published on behalf of the Psychosocial Interest Group and the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Blatter Tobias Ueli, Witte Harald, Nakas Christos Theodoros, Leichtle Alexander Benedikt. Big data in laboratory medicine - FAIR quality for AI?. Diagnostics 2022;12(8):1923. https://doi.org/10.3390/diagnostics12081923 PDF | BibTeX | RIS | DOI

Blatter Tobias U., Witte Harald, Fasquelle-Lopez Jules, Raisaro Jean Louis, Leichtle Alexander B.. Cohort profile: Swiss BioRef: the building blocks of a nationwide IT infrastructure in Switzerland for generating precise reference intervals. preprint; 2022. https://doi.org/10.1101/2022.08.30.22279391 BibTeX | RIS | DOI

Franchini Filippo, Kusejko Katharina, Marzolini Catia, Tellenbach Christoph, Rossi Simona, Stampf Susanne, Koller Michael, Stoyanov Jivko, Möller Burkhard, Leichtle Alexander Benedikt. Collaborative challenges of multi-cohort projects in pharmacogenetics — why time is essential for meaningful collaborations. JMIR Formative Research 2022;6(9):e36759. https://doi.org/10.2196/36759 PDF | BibTeX | RIS | DOI

Liniger Zara, Ellenberger Benjamin, Leichtle Alexander Benedikt. Computational evidence for laboratory diagnostic pathways: extracting predictive analytes for myocardial ischemia from routine hospital data. Diagnostics 2022;12(12):3148. https://doi.org/10.3390/diagnostics12123148 PDF | BibTeX | RIS | DOI

Boehl Gabriela, Raguindin Peter Francis, Valido Ezra, Bertolo Alessandro, Itodo Oche Adam, Minder Beatrice, Lampart Patricia, Scheel-Sailer Anke, Leichtle Alexander, Glisic Marija, Stoyanov Jivko. Endocrinological and inflammatory markers in individuals with spinal cord injury: a systematic review and meta-analysis. Reviews in Endocrine and Metabolic Disorders 2022;23(5):1035-1050. https://doi.org/10.1007/s11154-022-09742-9 PDF | BibTeX | RIS | DOI

Pham Truong-Thanh, Andrey Diego O., Stampf Susanne, Burkhard Sara H., Hirzel Cédric, Tschopp Johnathan, Ullrich Kathrin, Strahm Carol, Schreiber Peter W., Boillat-Blanco Noémie, Garzoni Christian, Khanna Nina, Manuel Oriol, Mueller Nicolas J., Suva Domizio, van Delden Christian, Uçkay Ilker, Neofytos Dionysios. Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients. American Journal of Transplantation 2022;22(12):3031-3046. https://doi.org/10.1111/ajt.17184 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Witte Harald, Nakas Christos, Bally Lia, Leichtle Alexander Benedikt. Machine learning prediction of hypoglycemia and hyperglycemia from electronic health records: algorithm development and validation. JMIR Formative Research 2022;6(7):e36176. https://doi.org/10.2196/36176 PDF | BibTeX | RIS | DOI

Triep Karen, Leichtle Alexander Benedikt, Meister Martin, Fiedler Georg Martin, Endrich Olga. Real-world health data and precision for the diagnosis of acute kidney injury, acute-on-chronic kidney disease, and chronic kidney disease: observational study. JMIR Medical Informatics 2022;10(1):e31356. https://doi.org/10.2196/31356 PDF | BibTeX | RIS | DOI

Magyar Benjamin P., Santi Maristella, Sommer Grit, Nuoffer Jean-Marc, Leichtle Alexander, Grössl Michael, Fluck Christa E.. Short-term fasting attenuates overall steroid hormone biosynthesis in healthy young women. Journal of the Endocrine Society 2022;6(7):bvac075. https://doi.org/10.1210/jendso/bvac075 PDF | BibTeX | RIS | DOI

Schreiber P. W., Laager M., Boggian K., Neofytos D., van Delden C., Egli A., Dickenmann M., Hirzel C., Manuel O., Koller M., Rossi S., Schmied B., Gürke L., Matter M., Berney T., de Rougemont O., Kuster S. P., Stampf S., Mueller N. J., Amico P., Aubert J.-D., Banz V., Beckmann S., Beldi G., Berger C., Berishvili E., Berzigotti A., Binet I., Bochud P.-Y., Branca S., Bucher H., Catana E., Cairoli A., Chalandon Y., De Geest S., De Rougemont O., De Seigneux S., Dickenmann M., Dreifuss J. L., Duchosal M., Fehr T., Ferrari-Lacraz S., Garzoni C., Golshayan D., Goossens N., Halter F. H. J., Heim D., Hess C., Hillinger S., Hirsch H. H., Hirt P., Hofbauer G., Huynh-Do U., Immer F., Koller M., Laager M., Laesser B., Lamoth F., Lehmann R., Leichtle Alexander, Manuel O., Marti H. P., Martinelli M., McLin V., Mellac K., Merçay A., Mettler K., Müller A., Mueller N. J., Müller-Arndt U., Müllhaupt B., Nägeli M., Oldani G., Pascual M., Passweg J., Pazeller R., Posfay-Barbe K., Rick J., Rosselet A., Rossi S., Rothlin S., Ruschitzka F., Schachtner T., Schanz U., Schaub S., Scherrer A., Schnyder A., Schuurmans M., Schwab S., Sengstag T., Simonetta F., Stampf S., Steiger J., Stirnimann G., Stürzinger U., Van Delden C., Venetz J.-P., Villard J., Vionnet J., Wick M., Wilhelm M., Yerly P.. Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study. Journal of Hospital Infection 2022;128:47-53. https://doi.org/10.1016/j.jhin.2022.07.009 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Dirchwolf Melisa, Becchetti Chiara, Gschwend Sarah G., Toso Christian, Dutkowski Philipp, Immer Franz, Beyeler Franziska, Rossi Simona, Schropp Jonas, Dufour Jean-François, Banz Vanessa, Amico Patrizia, Axel Andres, Aubert John-David, Banz Vanessa, Sonja Beckmann, Beldi Guido, Benden Christian, Berger Christoph, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Carrel Thierry, Catana Emmanuelle, Chalandon Yves, de Geest Sabina, de Rougemont Olivier, Dickenmann Michael, Dreifuss Joëlle L., Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Garzoni Christian, Soccal Paola G., Gaudet Christophe, Giostra Emiliano, Golshayan Déla, Hadaya Karine, Halter Jörg, Hauri Dimitri, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans, Hirt Patricia, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Laesser Bettina, Lang Brian, Lehmann Roger, Leichtle Alexander, Lovis Christian, Manuel Oriol, Marti Hans-Peter, Martin Pierre Y., Martinelli Michele, Mellac Katell, Merçay Aurélia, Mettler Karin, Meylan Pascal, Mueller Nicolas, Müller Antonia, Müller Thomas, Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Pascual Manuel, Posfay-Barbe Klara, Rick Juliane, Rosselet Anne, Rossi Simona, Rothlin Silvia, Ruschitzka Frank, Schanz Urs, Schaub Stefan, Schnyder Aurelia, Schuurmans Macé, Simonetta Federico, Staufer Katharina, Stampf Susanne, Steiger Jürg, Stirniman Guido, Stürzinger Ueli, Toso Christian, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhlem Markus, Yerly Patrick. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality. HPB 2022;24(7):1168-1176. https://doi.org/10.1016/j.hpb.2021.12.009 BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Müller Martin, Sägesser Nadine, Keller Peter M., Arampatzis Spyridon, Steffens Benedict, Ehrhard Simone, Leichtle Alexander B.. Urine flow cytometry parameter cannot safely predict contamination of urine — a cohort study of a swiss emergency department using machine learning techniques. Diagnostics 2022;12(4):1008. https://doi.org/10.3390/diagnostics12041008 PDF | BibTeX | RIS | DOI

2021

Stampf Susanne, Mueller Nicolas J., van Delden Christian, Pascual Manuel, Manuel Oriol, Banz Vanessa, Binet Isabelle, De Geest Sabina, Bochud Pierre-Yves, Leichtle Alexander, Schaub Stefan, Steiger Jürg, Koller Michael. Cohort profile: the Swiss Transplant Cohort Study (STCS): a nationwide longitudinal cohort study of all solid organ recipients in Switzerland. BMJ Open 2021;11(12):e051176. https://doi.org/10.1136/bmjopen-2021-051176 PDF | BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

Arnold Markus, Schweizer Juliane, Nakas Christos T., Schütz Valerie, Westphal Laura P., Inauen Corinne, Pokorny Thomas, Luft Andreas, Leichtle Alexander, Arnold Marcel, Bicvic Antonela, Fischer Urs, De Marchis Gian Marco, Bonati Leo H., Müller Mandy D., Kahles Timo, Nedeltchev Krassen, Cereda Carlo W., Kägi Georg, Bustamante Alejandro, Montaner Joan, Ntaios George, Foerch Christian, Spanaus Katharina, von Eckardstein Arnold, Katan Mira. Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: results from the BIOSIGNAL study. European Heart Journal 2021;42(22):2186-2196. https://doi.org/10.1093/eurheartj/ehab081 BibTeX | RIS | DOI

Cadamuro Janne, Hillarp Andreas, Unger Axel, von Meyer Alexander, Bauçà Josep Miquel, Plekhanova Olga, Linko-Parvinen Anna, Watine Joseph, Leichtle Alexander, Buchta Christoph, Haschke-Becher Elisabeth, Eisl Christoph, Winzer Johannes, Kristoffersen Ann Helen. Presentation and formatting of laboratory results: a narrative review on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group "postanalytical phase" (WG-POST). Critical Reviews in Clinical Laboratory Sciences 2021;58(5):329-353. https://doi.org/10.1080/10408363.2020.1867051 BibTeX | RIS | DOI

Denhaerynck Kris, Goldfarb‐Rumyantzev Alexander S., Sandhu Gurprataap, Beckmann Sonja, Huynh‐Do Uyen, Binet Isabelle, De Geest Sabina. Pre‐transplant Social Adaptability Index and clinical outcomes in renal transplantation: the Swiss Transplant Cohort study. Clinical Transplantation 2021;35(4):e14218. https://doi.org/10.1111/ctr.14218 BibTeX | RIS | DOI Published for the Psychosocial Interest Group, Swiss Transplant Cohort Study. Please see publisher's website for further details.

Bietenbeck Andreas, Cadamuro Janne, Holdenrieder Stefan, Leichtle Alexander Benedikt, Ludwig Amei, von Meyer Alexander, Nauck Matthias, Orth Matthias, Özçürümez Mustafa, Ponader Alexander, Streichert Thomas, Strobl Dominik, Tolios Alexander, Wiegel Bernhard, Gassner Ulrich M.. Requirements for electronic laboratory reports according to the German guideline Rili-BAEK and ISO 15189. Journal of Laboratory Medicine 2021;45(4-5):197-203. https://doi.org/10.1515/labmed-2020-0130 PDF | BibTeX | RIS | DOI

Musy Sarah N., Endrich Olga, Leichtle Alexander B., Griffiths Peter, Nakas Christos T., Simon Michael. The association between nurse staffing and inpatient mortality: a shift-level retrospective longitudinal study. International Journal of Nursing Studies 2021;120:103950. https://doi.org/10.1016/j.ijnurstu.2021.103950 PDF | BibTeX | RIS | DOI

Maurer Martin H., Brönnimann Michael, Schroeder Christophe, Ghadamgahi Ehssan, Streitparth Florian, Heverhagen Johannes T., Leichtle Alexander, de Bucourt Maximilian, Meyl Tobias Philipp. Time requirement and feasibility of a systematic quality peer review of reporting in radiology. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 2021;193(2):160-167. https://doi.org/10.1055/a-1178-1113 BibTeX | RIS | DOI

Schweiger M., Erdil T., Di Bernardo S., Balmer C., Yildiz M., Kadner A., Amico Patrizia, Axel Andres, Aubert John-David, Banz Vanessa, Sonja Beckmann, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Carrel Thierry, Catana Emmanuelle, Chalandon Yves, De Geest Sabina, De Rougemont Olivier, Dickenmann Michael, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Garzoni Christian, Soccal Paola Gasche, Gaudet Christophe, Golshayan Déla, Goossens Nicolas, Hadaya Karine, Halter Jörg, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans, Hirt Patricia, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Laager Mirjam, Laesser Bettina, Lehmann Roger, Leichtle Alexander, Lovis Christian, Manuel Oriol, Marti Hans-Peter, Martin Pierre Yves, Martinelli Michele, McLin Valérie, Mellac Katell, Merçay Aurélia, Mettler Karin, Mueller Nicolas, Müller Antonia, Müller Thomas, Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Posfay-Barbe Klara, Rick Juliane, Rosselet Anne, Rossi Simona, Rothlin Silvia, Ruschitzka Frank, Schanz Urs, Schaub Stefan, Schnyder Aurelia, Schuurmans Macé, Sengstag Thierry, Simonetta Federico, Staufer Katharina, Stampf Susanne, Steiger Jürg, Stirniman Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhlem Markus, Yerly Patrick. Use of induction therapy in pediatric heart transplant recipients in Switzerland – analysis of the Swiss national database. Transplant Immunology 2021;68:101443. https://doi.org/10.1016/j.trim.2021.101443 BibTeX | RIS | DOI Published on behalf of the Swiss Transplant Cohort Study. Please see publisher's website for further details.

2020

Freiburghaus Katrin, Leichtle Alexander B., Nakas Christos T., Fiedler Georg M., Largiadèr Carlo R.. Effects of freezing and thawing procedures on selected clinical chemistry parameters in plasma. Biopreservation and Biobanking 2020;18(4):297-304. https://doi.org/10.1089/bio.2020.0005 BibTeX | RIS | DOI

Arnold M., Nakas C., Luft A., Christ-Crain M., Leichtle Alexander B., Katan M.. Independent prognostic value of MR-proANP levels in stroke patients is unaltered over time [Abstract]. International Journal of Stroke 2020;15(1_suppl):629. https://doi.org/10.1177/1747493020963387 BibTeX | RIS | DOI

Arnold Markus, Nakas Christos, Luft Andreas, Christ-Crain Mirjam, Leichtle Alexander, Katan Mira. Independent prognostic value of MRproANP (Midregional Proatrial Natriuretic Peptide) levels in patients with stroke is unaltered over time. Stroke 2020;51(6):1873-1875. https://doi.org/10.1161/strokeaha.120.029333 BibTeX | RIS | DOI

Musy Sarah N., Endrich Olga, Leichtle Alexander B., Griffiths Peter, Nakas Christos T., Simon Michael. Longitudinal study of the variation in patient turnover and patient-to-nurse ratio: descriptive analysis of a Swiss university hospital. Journal of Medical Internet Research 2020;22(4):e15554. https://doi.org/10.2196/15554 PDF | BibTeX | RIS | DOI

Endrich Olga, Leichtle Alexander. Nierendiagnostik – neue Aspekte durch Data Science. Pipette - Swiss Laboratory Medicine 2020;2020(6):13-15. BibTeX | RIS | URL

Dhayat Nasser A., Pruijm Menno, Ponte Belen, Ackermann Daniel, Leichtle Alexander Benedikt, Devuyst Olivier, Ehret Georg, Guessous Idris, Pechère-Bertschi Antoinette, Pastor Johanne, Martin Pierre-Yves, Burnier Michel, Fiedler Georg-Martin, Vogt Bruno, Moe Orson W., Bochud Murielle, Fuster Daniel G.. Parathyroid hormone and plasma phosphate are predictors of soluble α-klotho levels in adults of European descent. The Journal of Clinical Endocrinology & Metabolism 2020;105(4):e1135-e1143. https://doi.org/10.1210/clinem/dgz232 BibTeX | RIS | DOI

Diem Lara, Bürge Maxine, Leichtle Alexander, Hakim Arsany, Chan Andrew, Salmen Anke, Evangelopoulos Maria-Eleptheria, Hoepner Robert. Pathological cerebrospinal fluid protein concentration and albumin quotient at relapse predicts short-term disability progression in multiple sclerosis: a retrospective single center observational study. Therapeutic Advances in Neurological Disorders 2020;13:1-7. https://doi.org/10.1177/1756286420975909 PDF | BibTeX | RIS | DOI

Schefold Joerg C., Gerber Joël L., Angehrn Michelle C., Müller Martin, Messmer Anna S., Leichtle Alexander B., Fiedler Georg M., Exadaktylos Aristomenis K., Pfortmueller Carmen A.. Renal function–adjusted d-dimer levels in critically ill patients with suspected thromboembolism. Critical Care Medicine 2020;48(4):e270-e276. https://doi.org/10.1097/ccm.0000000000004204 BibTeX | RIS | DOI

Raisaro Jean Louis, Troncoso-Pastoriza Juan Ramòn, Pradervand Sylvain, Cuendet Michel, Misbach Mickael, Sa Joao, Marino Francesco, Freundler Nicolas, Rosat Nicolas, Cavin David, Leichtle Alexander, Fellay Jacques, Michielin Olivier, Hubaux Jean-Pierre. SPHN/PHRT – MedCo in action: empowering the swiss molecular tumor board with privacy-preserving and real-time patient discovery. Pape-Haugaard Louise B., Lovis Christian, Madsen Inge Cort, Weber Patrick, Hostrup Nielsen Per, Scott Philip, editors. Digital personalized health and medicine: proceedings of MIE 2020 Amsterdam: IOS Press; 2020. 1161-1162. https://doi.org/10.3233/shti200345 PDF | BibTeX | RIS | DOI

Rindlisbacher Barbara, Schild Christof, Egger Florence, Bacher Vera U., Pabst Thomas, Leichtle Alexander, Andres Martin, Sédille-Mostafaie Nazanin. Serum free light chain assay: shift toward a higher κ/λ ratio. The Journal of Applied Laboratory Medicine 2020;5(1):114-125. https://doi.org/10.1093/jalm.2019.029330 BibTeX | RIS | DOI

Kohl Schwarz A. S., Burkard S., Mitter V. R., Leichtle Alexander B., Fink A., von Wolff M.. Short-term application of ibuprofen before ovulation. Facts, Views & Vision in ObGyn 2020;12(3):179-184. PDF | BibTeX | RIS | URL

Herzig David, Nakas Christos T., Stalder Janine, Kosinski Christophe, Laesser Céline, Dehais Joachim, Jaeggi Raphael, Leichtle Alexander Benedikt, Dahlweid Fried-Michael, Stettler Christoph, Bally Lia. Volumetric food quantification using computer vision on a depth-sensing smartphone: preclinical study. JMIR mHealth and uHealth 2020;8(3):e15294. https://doi.org/10.2196/15294 PDF | BibTeX | RIS | DOI

2019

Schütz Narayan, Leichtle Alexander B., Riesen Kaspar. A comparative study of pattern recognition algorithms for predicting the inpatient mortality risk using routine laboratory measurements. Artificial Intelligence Review 2019;52(4):2559-2573. https://doi.org/10.1007/s10462-018-9625-3 BibTeX | RIS | DOI

van Hoek Jasper, Huber Adrian, Leichtle Alexander, Härmä Kirsi, Hilt Daniella, von Tengg-Kobligk Hendrik, Heverhagen Johannes, Poellinger Alexander. A survey on the future of radiology among radiologists, medical students and surgeons: students and surgeons tend to be more skeptical about artificial intelligence and radiologists may fear that other disciplines take over. European Journal of Radiology 2019;121:108742. https://doi.org/10.1016/j.ejrad.2019.108742 BibTeX | RIS | DOI

Bally L., Herzig D., Leichtle Alexander, Previtali N., Briner A., Stettler C.. ATTD19-0163 Towards automated macronutrient assessment [Abstract]. Diabetes Technology & Therapeutics 2019;21(S1):A16. https://doi.org/10.1089/dia.2019.2525.abstracts BibTeX | RIS | DOI

Franco-Pereira Alba M., Nakas Christos T., Leichtle Alexander B., Pardo M. Carmen. Bootstrap-based testing approaches for the assessment of the diagnostic accuracy of biomarkers subject to a limit of detection. Statistical Methods in Medical Research 2019;28(5):1564-1578. https://doi.org/10.1177/0962280218769334 BibTeX | RIS | DOI

Schuh Sabine K., Seidenberg Ruth, Arampatzis Spyridon, Leichtle Alexander B., Hautz Wolf E., Exadaktylos Aristomenis K., Schechter Clyde B., Müller Martin. Diagnosis of urinary tract infections by urine flow cytometry: adjusted cut-off values in different clinical presentations. Disease Markers 2019;2019:5853486. https://doi.org/10.1155/2019/5853486 PDF | BibTeX | RIS | DOI

Wolfensberger Nathan, Georgiou Georgios, Giabbani Evelyne, Reusser Marianne, Njue Linet M., Fiedler Martin, Leichtle Alexander B., Nagler Michael. Rapid centrifugation in the routine hemostasis laboratory. Thrombosis and Haemostasis 2019;119(12):2025-2033. https://doi.org/10.1055/s-0039-1696712 PDF | BibTeX | RIS | DOI

Scholz Godehard A., Leichtle Alexander B., Scherer Almut, Arndt Uta, Fiedler Martin, Aeberli Daniel, Finckh Axel, Gabay Cem, Kyburz Diego, Villiger Peter M., Möller Burkhard. The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis. British Journal of Haematology 2019;186(1):101-112. https://doi.org/10.1111/bjh.15895 BibTeX | RIS | DOI

Egli-Spichtig Daniela, Imenez Silva Pedro Henrique, Glaudemans Bob, Gehring Nicole, Bettoni Carla, Zhang Martin Y.H., Pastor-Arroyo Eva M., Schönenberger Désirée, Rajski Michal, Hoogewijs David, Knauf Felix, Misselwitz Benjamin, Frey-Wagner Isabelle, Rogler Gerhard, Ackermann Daniel, Ponte Belen, Pruijm Menno, Leichtle Alexander, Fiedler Georg-Martin, Bochud Murielle, Ballotta Virginia, Hofmann Sandra, Perwad Farzana, Föller Michael, Lang Florian, Wenger Roland H., Frew Ian, Wagner Carsten A.. Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation. Kidney International 2019;96(4):890-905. https://doi.org/10.1016/j.kint.2019.04.009 BibTeX | RIS | DOI

Müller M., Schefold J. C., Leichtle Alexander B., Srivastava D., Lindner G., Exadaktylos A. K., Pfortmueller C. A.. qSOFA score not predictive of in-hospital mortality in emergency patients with decompensated liver cirrhosis. Medizinische Klinik - Intensivmedizin und Notfallmedizin 2019;114(8):724-732. https://doi.org/10.1007/s00063-018-0477-z BibTeX | RIS | DOI

2018

Findeisen P., Zahn I., Fiedler G. M., Leichtle Alexander B., Wang S., Soria G., Johnson P., Henzell J., Hegel J. K., Bendavid C., Collet N., McGovern M., Klopprogge K.. Doubling immunochemistry laboratory testing efficiency with the cobas e 801 module while maintaining consistency in analytical performance. Clinical Biochemistry 2018;58:86-93. https://doi.org/10.1016/j.clinbiochem.2018.05.019 BibTeX | RIS | DOI

Rindlisbacher Barbara, Strebel Carina, Guler Sabina, Kollár Attila, Geiser Thomas, Martin Fiedler Georg, Leichtle Alexander Benedikt, Bovet Cédric, Funke-Chambour Manuela. Exhaled breath condensate as a potential biomarker tool for idiopathic pulmonary fibrosis — a pilot study. Journal of Breath Research 2018;12(1):016003. https://doi.org/10.1088/1752-7163/aa840a BibTeX | RIS | DOI

Dahlweid Fried-Michael, Kämpf Matthias, Leichtle Alexander. Interoperability of laboratory data in Switzerland – a spotlight on Bern. Journal of Laboratory Medicine 2018;42(6):251-258. https://doi.org/10.1515/labmed-2018-0314 PDF | BibTeX | RIS | DOI

Horn Michael P., Peter Anna Maria, Righini Grunder Franziska, Leichtle Alexander B., Spalinger Johannes, Schibli Susanne, Sokollik Christiane. PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease. PLoS ONE 2018;13(12):e0208974. https://doi.org/10.1371/journal.pone.0208974 PDF | BibTeX | RIS | DOI

Lesche Dorothea, Sigurdardottir Vilborg, Leichtle Alexander B., Nakas Christos T., Christians Uwe, Englberger Lars, Fiedler Martin, Largiadèr Carlo R., Mohacsi Paul, Sistonen Johanna. Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement. Metabolomics 2018;14(1):3. https://doi.org/10.1007/s11306-017-1294-8 BibTeX | RIS | DOI

Müller Martin, Seidenberg Ruth, Schuh Sabine K., Exadaktylos Aristomenis K., Schechter Clyde B., Leichtle Alexander B., Hautz Wolf E.. The development and validation of different decision-making tools to predict urine culture growth out of urine flow cytometry parameter. PLoS ONE 2018;13(2):e0193255. https://doi.org/10.1371/journal.pone.0193255 PDF | BibTeX | RIS | DOI

Walder Anna, Müller Martin, Dahdal Suzan, Sidler Daniel, Devetzis Vasilios, Leichtle Alexander B., Fiedler Martin G., Popp Albrecht W., Lippuner Kurt, Vogt Bruno, Uehlinger Dominik, Huynh-Do Uyen, Arampatzis Spyridon. The effect of a previous created distal arteriovenous-fistula on radial bone DXA measurements in prevalent renal transplant recipients. PLoS ONE 2018;13(7):e0200708. https://doi.org/10.1371/journal.pone.0200708 PDF | BibTeX | RIS | DOI

2017

Bally Lia, Bovet Cédric, Nakas Christos T., Zueger Thomas, Prost Jean-Christophe, Nuoffer Jean-Marc, Leichtle Alexander B., Fiedler Georg Martin, Stettler Christoph. A metabolomics approach to uncover effects of different exercise modalities in type 1 diabetes. Metabolomics 2017;13(7):78. https://doi.org/10.1007/s11306-017-1217-8 BibTeX | RIS | DOI

Kattner Andreas, Ahmad Sufian S., Leichtle Alexander Benedikt, Fiedler Georg-Martin, Exadaktylos Aristomenis K., Heverhagen Johannes, Haider Dominik G.. Assessment of acute cardiac function via post-resuscitation triple-rule-out computed tomography. Emergency Medicine: Open Access 2017;7(1):1000346. PDF | BibTeX | RIS | URL

Zinkernagel Martin S., Zysset-Burri Denise C., Keller Irene, Berger Lieselotte E., Leichtle Alexander B., Largiadèr Carlo R., Fiedler Georg M., Wolf Sebastian. Association of the intestinal microbiome with the development of neovascular age-related macular degeneration. Scientific Reports 2017;7(1):40826. https://doi.org/10.1038/srep40826 PDF | BibTeX | RIS | DOI

Haider Dominik G., Klemenz Thomas, Fiedler Georg Martin, Nakas Christos T., Exadaktylos Aristomenis K., Leichtle Alexander B.. High sensitive cardiac troponin T: testing the test. International Journal of Cardiology 2017;228:779-783. https://doi.org/10.1016/j.ijcard.2016.10.043 BibTeX | RIS | DOI

Haider Dominik, Klemenz Thomas, Fiedler Georg Martin, Nakas Christos T., Exadaktylos Aristomeins K., Leichtle Alexander. In response to the letter to the editor on our manuscript "High sensitive cardiac troponin T: Testing the test" by Dr. Badertscher [Letter]. International Journal of Cardiology 2017;234:127. https://doi.org/10.1016/j.ijcard.2017.01.114 BibTeX | RIS | DOI

Pfortmueller Carmen A., Lindner Gregor, Funk Georg-Christian, Leichtle Alexander B., Fiedler Georg M., Schwarz Christoph, Exadaktylos Aristomenis K.. Role of D-Dimer testing in venous thromboembolism with concomitant renal insufficiency in critical care [Letter]. Intensive Care Medicine 2017;43(3):470-471. https://doi.org/10.1007/s00134-016-4646-3 BibTeX | RIS | DOI

Conrad Tim O. F., Genzel Martin, Cvetkovic Nada, Wulkow Niklas, Leichtle Alexander, Vybiral Jan, Kutyniok Gitta, Schütte Christof. Sparse proteomics analysis – a compressed sensing-based approach for feature selection and classification of high-dimensional proteomics mass spectrometry data. BMC Bioinformatics 2017;18(1):160. https://doi.org/10.1186/s12859-017-1565-4 PDF | BibTeX | RIS | DOI

von Meyer Alexander, Cadamuro Janne, Streichert Thomas, Gurr Eberhard, Fiedler G. Martin, Leichtle Alexander, Petersmann Astrid, Pick Karl-Heinz, Orth Matthias, Risch Lorenz, Sonntag Oswald, Schmitt York, Wiegel Bernhard, Töpfer Gottfried, Guder Walter G.. Standard-Arbeitsanleitung zur peripher venösen Blutentnahme für die labormedizinische Diagnostik. LaboratoriumsMedizin 2017;41(6):333-340. https://doi.org/10.1515/labmed-2017-0127 BibTeX | RIS | DOI Veröffentlicht für die Arbeitsgruppe „Extraanalytische Qualität“ der Deutschen Gesellschaft für Klinische Chemie und Laboratoriumsmedizin (DGKL), der Schweizerischen Gesellschaft für Klinische Chemie (SGKC/SSCC) und der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC). Siehe Verlagswebseite für weitere Informationen.

Müller Martin, Guignard Viviane, Schefold Joerg C., Leichtle Alexander B., Exadaktylos Aristomenis K., Pfortmueller Carmen A.. Utility of quick sepsis-related organ failure assessment (qSOFA) to predict outcome in patients with pneumonia. PLoS ONE 2017;12(12):e0188913. https://doi.org/10.1371/journal.pone.0188913 PDF | BibTeX | RIS | DOI

2016

Züger T., Bally L., Speck C., Kempf P., Pasi N., Rosset R., Feller K., Fiedler M., Leichtle Alexander, Tappy L., Wilhelm M., Laimer M., Stettler C.. 506 Metabolic effects of combined glucose-fructose supplementation versus glucose alone in exercising individuals with type 1 diabetes [Abstract]. Diabetologia 2016;59(Supplement 1):S243-S244. https://doi.org/10.1007/s00125-016-4046-9 BibTeX | RIS | DOI

Nakas Christos T., Schütz Narayan, Werners Marcus, Leichtle Alexander B.. Accuracy and calibration of computational approaches for inpatient mortality predictive modeling. PLoS ONE 2016;11(7):e0159046. https://doi.org/10.1371/journal.pone.0159046 PDF | BibTeX | RIS | DOI

Sauter Thomas C., Ziegenhorn Stephan, Ahmad Sufian S., Hautz Wolf E., Ricklin Meret E., Leichtle Alexander Benedikt, Fiedler Georg-Martin, Haider Dominik G., Exadaktylos Aristomenis K.. Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation. Journal of Negative Results in BioMedicine 2016;15(1):12. https://doi.org/10.1186/s12952-016-0055-y PDF | BibTeX | RIS | DOI

Bally Lia, Zueger Thomas, Stettler Christoph, Leichtle Alexander Benedikt. Computed exercise plasma lactate concentrations: a conversion formula. Practical Laboratory Medicine 2016;4:11-15. https://doi.org/10.1016/j.plabm.2015.11.002 PDF | BibTeX | RIS | DOI

Lesche Dorothea, Geyer Roland, Lienhard Daniel, Nakas Christos T., Diserens Gaëlle, Vermathen Peter, Leichtle Alexander B.. Does centrifugation matter? Centrifugal force and spinning time alter the plasma metabolome. Metabolomics 2016;12(10):159. https://doi.org/10.1007/s11306-016-1109-3 PDF | BibTeX | RIS | DOI

Dhayat Nasser A., Ackermann Daniel, Pruijm Menno, Ponte Belen, Ehret Georg, Guessous Idris, Leichtle Alexander Benedikt, Paccaud Fred, Mohaupt Markus, Fiedler Georg-Martin, Devuyst Olivier, Pechère-Bertschi Antoinette, Burnier Michel, Martin Pierre-Yves, Bochud Murielle, Vogt Bruno, Fuster Daniel G.. Fibroblast growth factor 23 and markers of mineral metabolism in individuals with preserved renal function. Kidney International 2016;90(3):648-657. https://doi.org/10.1016/j.kint.2016.04.024 BibTeX | RIS | DOI

Pichler Hefti Jacqueline, Leichtle Alexander, Stutz Monika, Hefti Urs, Geiser Thomas, Huber Andreas R., Merz Tobias M.. Increased endothelial microparticles and oxidative stress at extreme altitude. European Journal of Applied Physiology 2016;116(4):739-748. https://doi.org/10.1007/s00421-015-3309-3 BibTeX | RIS | DOI

Dhayat Nasser, Ackermann Daniel, Pruijm Menno, Ponte Belen, Ehret Georg, Guessous Idris, Leichtle Alexander Benedikt, Paccaud Fred, Mohaupt Markus, Fiedler Georg-Martin, Devuyst Olivier, Pechère-Bertschi Antoinette, Burnier Michel, Martin Pierre-Yves, Bochud Murielle, Vogt Bruno, Fuster Daniel G.. MP359 FGF23 and markers of mineral metabolism in subjects with preserved renal function [Abstract]. Nephrology Dialysis Transplantation (ndt) 2016;31(suppl_1):i459. https://doi.org/10.1093/ndt/gfw190.16 BibTeX | RIS | DOI

Pfortmueller Carmen Andrea, Drexel Christian, Krähenmann-Müller Simone, Leichtle Alexander Benedikt, Fiedler Georg Martin, Lindner Gregor, Exadaktylos Aristomenis Konstantinos. S-100 B concentrations are a predictor of decreased survival in patients with major trauma, independently of head injury. PLoS ONE 2016;11(3):e0152822. https://doi.org/10.1371/journal.pone.0152822 PDF | BibTeX | RIS | DOI

Möller B., Leichtle Alexander B., Meyer P., Fiedler M., Finckh A., Kyburz D., Gabay C., Villiger P. M.. THU0088 Iron deficiency and low erythropoietin concentrations are frequent anemia causing factors in rheumatoid arthritis [Abstract]. Annals of the Rheumatic Diseases 2016;75(Supplement 2):210-211. https://doi.org/10.1136/annrheumdis-2016-eular.2226 BibTeX | RIS | DOI

Haider Dominik G., Lindner Gregor, Wolzt Michael, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Sauter Thomas C., Fuhrmann Valentin, Exadaktylos Aristomenis K.. Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study. Journal of Negative Results in BioMedicine 2016;15(1):1. https://doi.org/10.1186/s12952-016-0044-1 PDF | BibTeX | RIS | DOI

2015

Leichtle Alexander, Findeisen Peter. 7.7 Biobanking. In: Guder Walter G., Narayanan Sheshadri, editors. Pre-examination procedures in laboratory diagnostics: preanalytical aspects and their impact on the quality of medical laboratory results. Berlin: DeGruyter; 2015. p. 328-333. https://doi.org/10.1515/9783110334043-038 BibTeX | RIS | DOI

Studer Martina, Goeggel Simonetti Barbara, Heinks Theda, Steinlin Maja, Leichtle Alexander, Berger Steffen, Joeris Alexander. Acute S100B in serum is associated with cognitive symptoms and memory performance 4 months after paediatric mild traumatic brain injury. Brain Injury 2015;29(13-14):1667-1673. https://doi.org/10.3109/02699052.2015.1075250 BibTeX | RIS | DOI

Leichtle Alexander. Biomarker – vom Sein und Wesen. LaboratoriumsMedizin 2015;39(2):97-101. https://doi.org/10.1515/labmed-2015-0033 PDF | BibTeX | RIS | DOI | URL

Sauter Thomas C., Lindner Gregor, Ahmad Sufian S., Leichtle Alexander Benedikt, Fiedler Georg-Martin, Exadaktylos Aristomenis K., Haider Dominik G.. Calcium disorders in the emergency department: independent risk factors for mortality. PLoS ONE 2015;10(7):e0132788. https://doi.org/10.1371/journal.pone.0132788 PDF | BibTeX | RIS | DOI

Dhayat Nasser, Ackermann Daniel, Pruijm Menno, Ponte Belen, Ehret Georg, Guessous Idris, Leichtle Alexander Benedikt, Paccaud Fred, Mohaupt Markus, Fiedler Georg-Martin, Burnier Michel, Pechere-Bertschi Antoinette, Martin Pierre-Yves, Bochud Murielle, Vogt Bruno, Fuster Daniel. FGF23 and markers of mineral metabolism in subjects with preserved renal function [Abstract]. Swiss Medical Weekly 2015;145(Supplement):4S-5S. BibTeX | RIS

Haider Dominik G., Lindner Gregor, Ahmad Sufian S., Sauter Thomas, Wolzt Michael, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Exadaktylos Aristomenis K., Fuhrmann Valentin. Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study. European Journal of Internal Medicine 2015;26(7):504-507. https://doi.org/10.1016/j.ejim.2015.05.013 BibTeX | RIS | DOI

Haider Dominik G., Lindner Gregor, Wolzt Michael, Ahmad Sufian S., Sauter Thomas, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Fuhrmann Valentin, Exadaktylos Aristomenis K.. Hyperphosphatemia is an independent risk factor for mortality in critically ill patients: results from a cross-sectional study. PLoS ONE 2015;10(8):e0133426. https://doi.org/10.1371/journal.pone.0133426 PDF | BibTeX | RIS | DOI

Pfortmueller C., Wiemann C., Funk G. C., Leichtle Alexander B., Lindner G., Fiedler G. M., Exadaktylos A.. P01 Hypoglycemia is associated with increased mortality in patients with acute decompensated liver cirrhosis [Abstract]. Medizinische Klinik - Intensivmedizin und Notfallmedizin 2015;110(4):299. https://doi.org/10.1007/s00063-015-0036-9 BibTeX | RIS | DOI

Lindner G., Heldner Mirjam Rachel, Bernasconi Corrado Angelo, Funk G. C., Arnold Marcel, Schwarz C., Leichtle Alexander Benedikt, Fiedler Georg Martin, Gralla Jan, Mattle Heinrich, Exadaktylos Aristomenis, Fischer Urs Martin. Prevalence of dysnatremias and their implication on outcome during acute ischemic stroke and transient ischemic attack: a cross-sectional analysis [Abstract]. International Journal of Stroke 2015;10(Supplement 2):241. https://doi.org/10.1111/ijs.12479 BibTeX | RIS | DOI

Pfortmueller Carmen A., Pauchard-Neuwerth Sandra E., Leichtle Alexander Benedikt, Fiedler Georg M., Exadaktylos Aristomenis K., Lindner Gregor. Primary hyperventilation in the emergency department: a first overview. PLoS ONE 2015;10(6):e0129562. https://doi.org/10.1371/journal.pone.0129562 PDF | BibTeX | RIS | DOI

Pfortmueller C. A., Drexel C., Krähenmann-Müller S., Leichtle Alexander B., Fiedler G. M., Lindner G., Exadaktylos A. K.. S-100 B concentrations are a predictor of decreased survival in patients with major trauma independently of head injury [Abstract]. Intensive Care Medicine Experimental 2015;3(S1):A31. https://doi.org/10.1186/2197-425x-3-s1-a31 PDF | BibTeX | RIS | DOI

2014

Lindner Gregor, Pfortmüller Carmen A., Leichtle Alexander B., Fiedler Georg M., Exadaktylos Aristomenis K.. Age-related variety in electrolyte levels and prevalence of dysnatremias and dyskalemias in patients presenting to the emergency department. Gerontology 2014;60(5):420-423. https://doi.org/10.1159/000360134 BibTeX | RIS | DOI

Leichtle Alexander, Liniger Z., Lindner G., Fiedler G. M.. Big Data: time to remodel diagnostic paths [Abstract]. European Journal of Preventive Cardiology 2014;21(2_suppl):41. https://doi.org/10.1177/2047487314553173 BibTeX | RIS | DOI

Lindner Gregor, Funk Georg-Christian, Pfortmueller Carmen A., Leichtle Alexander B., Fiedler Georg M., Schwarz Christoph, Exadaktylos Aristomenis K., Puig Stefan. D-dimer to rule out pulmonary embolism in renal insufficiency. The American Journal of Medicine 2014;127(4):343-347. https://doi.org/10.1016/j.amjmed.2013.12.003 BibTeX | RIS | DOI

Pfortmueller Carmen Andrea, Lindner Gregor, Leichtle Alexander Benedikt, Fiedler Georg Martin, Exadaktylos Aristomenis Konstantinos. Diagnostic significance of high sensitivity troponin in diagnosis of blunt cardiac injury [Letter]. Intensive Care Medicine 2014;40(4):623-624. https://doi.org/10.1007/s00134-013-3204-5 BibTeX | RIS | DOI

Pfortmueller Carmen A., Funk Georg-Christian, Leichtle Alexander B., Fiedler Georg M., Schwarz Christoph, Exadaktylos Aristomenis K., Lindner Gregor. Electrolyte disorders and in-hospital mortality during prolonged heat periods: a cross-sectional analysis. PLoS ONE 2014;9(3):e92150. https://doi.org/10.1371/journal.pone.0092150 PDF | BibTeX | RIS | DOI

Marti Grischa, Schwarz Christoph, Leichtle Alexander B., Fiedler Georg-Martin, Arampatzis Spyridon, Exadaktylos Aristomenis K., Lindner Gregor. Etiology and symptoms of severe hypokalemia in emergency department patients. European Journal of Emergency Medicine 2014;21(1):46-51. https://doi.org/10.1097/mej.0b013e3283643801 BibTeX | RIS | DOI | URL

Pfortmueller Carmen Andrea, Wiemann Christoph, Funk Georg-Christian, Leichtle Alexander Benedikt, Fiedler Georg Martin, Exadaktylos Aristomenis Konstantinos, Lindner Gregor. Hypoglycemia is associated with increased mortality in patients with acute decompensated liver cirrhosis. Journal of Critical Care 2014;29(2):316.e7-316.e12. https://doi.org/10.1016/j.jcrc.2013.11.002 BibTeX | RIS | DOI

Lindner G., Funk G.-C., Leichtle Alexander B., Fiedler G. M., Schwarz C., Eleftheriadis T., Pasch A., Mohaupt M. G., Exadaktylos A. K., Arampatzis S.. Impact of proton pump inhibitor use on magnesium homoeostasis: a cross-sectional study in a tertiary emergency department. International Journal of Clinical Practice 2014;68(11):1352-1357. https://doi.org/10.1111/ijcp.12469 BibTeX | RIS | DOI

Dysli Chantal, Quellec Gwénolé, Abegg Mathias, Menke Marcel N., Wolf-Schnurrbusch Ute, Kowal Jens, Blatz Johannes, La Schiazza Olivier, Leichtle Alexander B., Wolf Sebastian, Zinkernagel Martin S.. Quantitative analysis of fluorescence lifetime measurements of the macula using the fluorescence lifetime imaging ophthalmoscope in healthy subjects. Investigative Opthalmology & Visual Science 2014;55(4):2106-2113. https://doi.org/10.1167/iovs.13-13627 BibTeX | RIS | DOI

Studer M., Hartmann S., Goeggel Simonetti B., Heinks T., Steinlin M., Leichtle Alexander, Berger S., Joeris A.. Serum marker S100B is associated with cognitive outcome and ongoing cognitive symptoms in children after mild traumatic brain injury [Abstract]. Swiss Medical Weekly 2014;144(Supplement):25S. BibTeX | RIS

2013

Pfortmueller Carmen A., Funk Georg-Christian, Marti Grischa, Leichtle Alexander B., Fiedler Georg M., Schwarz Christoph, Exadaktylos Aristomenis K., Lindner Gregor. Diagnostic performance of high-sensitive troponin T in patients with renal insufficiency. The American Journal of Cardiology 2013;112(12):1968-1972. https://doi.org/10.1016/j.amjcard.2013.08.028 BibTeX | RIS | DOI

Lindner Gregor, Pfortmueller Carmen A., Funk Georg-Christian, Leichtle Alexander B., Fiedler Georg Martin, Exadaktylos Aristomenis K.. High-sensitive troponin measurement in emergency department patients presenting with syncope: a retrospective analysis. PLoS ONE 2013;8(6):e66470. https://doi.org/10.1371/journal.pone.0066470 PDF | BibTeX | RIS | DOI

Lindner Gregor, Felber Rainer, Schwarz Christoph, Marti Grischa, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Zimmermann Heinz, Arampatzis Spyridon, Exadaktylos Aristomenis Konstantinos. Hypercalcemia in the ED: prevalence, etiology, and outcome. The American Journal of Emergency Medicine 2013;31(4):657-660. https://doi.org/10.1016/j.ajem.2012.11.010 BibTeX | RIS | DOI

Pfortmüller Carmen Andrea, Leichtle Alexander Benedikt, Fiedler Georg Martin, Exadaktylos Aristomenis Konstantinos, Lindner Gregor. Hyperkalemia in the emergency department: etiology, symptoms and outcome of a life threatening electrolyte disorder [Letter]. European Journal of Internal Medicine 2013;24(5):e59-e60. https://doi.org/10.1016/j.ejim.2013.02.010 BibTeX | RIS | DOI

Arampatzis Spyridon, Funk Georg-Christian, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Schwarz Christoph, Zimmermann Heinz, Exadaktylos Aristomenis Konstantinos, Lindner Gregor. Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis. BMC Medicine 2013;11(1):83. https://doi.org/10.1186/1741-7015-11-83 PDF | BibTeX | RIS | DOI

Arampatzis Spiros, Lindner Gregor, Funk Georg-Christian, Leichtle Alexander Benedikt, Fiedler Georg-Martin, Pasch Andreas, Mohaupt Markus, Exadaktylos Aristomenis. Impact of proton-pump inhibitors and diuretics on the risk of hypomagnesemia in patients admitted to the emergency department [Abstract]. Swiss Medical Weekly 2013;143(Supplement):4S. BibTeX | RIS

Leichtle Alexander. Neue "-omics"-Technologien und die Herausforderungen der Dateninterpretation. Pipette - Swiss Laboratory Medicine 2013;2013(4):10-11. BibTeX | RIS | URL

Leichtle Alexander Benedikt, Ceglarek Uta, Weinert Peter, Nakas Christos T., Nuoffer Jean-Marc, Kase Julia, Conrad Tim, Witzigmann Helmut, Thiery Joachim, Fiedler Georg Martin. Pancreatic carcinoma, pancreatitis, and healthy controls: metabolite models in a three-class diagnostic dilemma. Metabolomics 2013;9(3):677-687. https://doi.org/10.1007/s11306-012-0476-7 PDF | BibTeX | RIS | DOI

Leichtle Alexander Benedikt, Dufour Jean-François, Fiedler Georg Martin. Potentials and pitfalls of clinical peptidomics and metabolomics. Swiss Medical Weekly 2013;143(2324):w13801. https://doi.org/10.4414/smw.2013.13801 PDF | BibTeX | RIS | DOI

Mai Manuel, Tönjes Anke, Kovacs Peter, Stumvoll Michael, Fiedler Georg Martin, Leichtle Alexander Benedikt. Serum levels of acylcarnitines are altered in prediabetic conditions. PLoS ONE 2013;8(12):0082459. https://doi.org/10.1371/journal.pone.0082459 PDF | BibTeX | RIS | DOI

2012

Arampatzis Spyridon, Frauchiger Bettina, Fiedler Georg-Martin, Leichtle Alexander Benedikt, Buhl Daniela, Schwarz Christoph, Funk Georg-Christian, Zimmermann Heinz, Exadaktylos Aristomenis K., Lindner Gregor. Characteristics, symptoms, and outcome of severe dysnatremias present on hospital admission. The American Journal of Medicine 2012;125(11):1125.e1-1125.e7. https://doi.org/10.1016/j.amjmed.2012.04.041 BibTeX | RIS | DOI

Leichtle Alexander Benedikt, Nuoffer Jean-Marc, Ceglarek Uta, Kase Julia, Conrad Tim, Witzigmann Helmut, Thiery Joachim, Fiedler Georg Martin. Serum amino acid profiles and their alterations in colorectal cancer. Metabolomics 2012;8(4):643-653. https://doi.org/10.1007/s11306-011-0357-5 PDF | BibTeX | RIS | DOI

Schwarz C., Leichtle Alexander Benedikt, Arampatzis S., Fiedler G. M., Zimmermann H., Exadaktylos A. K., Lindner G.. Thyroid function and serum electrolytes: does an association really exist?. Swiss Medical Weekly 2012;142(3738):w13669. https://doi.org/10.4414/smw.2012.13669 PDF | BibTeX | RIS | DOI

2011

Leichtle Alexander, Ceglarek U., Conrad T., Hauss J., Witzigmann H., Thiery J., Fiedler G. M.. 0112 Metabolome alterations in coclorectal cancer [Abstract]. Clinical Chemistry and Laboratory Medicine 2011;49(Supplement 1):S249. https://doi.org/10.1515/cclm.2011.507 BibTeX | RIS | DOI

Ceglarek U., Leichtle Alexander, Kortz L., Thiery J., Fiedler G. M.. 1091 Protein quantificationin humanserum byfast chromatography and quadrupol/linear iontrap massspectrometry [Abstract]. Clinical Chemistry and Laboratory Medicine 2011;49(Supplement 1):S751. https://doi.org/10.1515/cclm.2011.528 BibTeX | RIS | DOI

Leichtle Alexander B., Helmschrodt Christin, Ceglarek Uta, Shai Iris, Henkin Yaakov, Schwarzfuchs Dan, Golan Rachel, Gepner Yftach, Stampfer Meir J., Blüher Matthias, Stumvoll Michael, Thiery Joachim, Fiedler Georg M.. Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. The American Journal of Clinical Nutrition 2011;94(5):1189-1195. https://doi.org/10.3945/ajcn.111.018119 BibTeX | RIS | DOI

Schumann Julia, Leichtle Alexander, Thiery Joachim, Fuhrmann Herbert. Fatty acid and peptide profiles in plasma membrane and membrane rafts of PUFA supplemented RAW264.7 macrophages. PLoS ONE 2011;6(8):e24066. https://doi.org/10.1371/journal.pone.0024066 PDF | BibTeX | RIS | DOI

Brauer Romy, Leichtle Alexander Benedikt, Fiedler Georg Martin, Thiery Joachim, Ceglarek Uta. Preanalytical standardization of amino acid and acylcarnitine metabolite profiling in human blood using tandem mass spectrometry. Metabolomics 2011;7(3):344-352. https://doi.org/10.1007/s11306-010-0256-1 BibTeX | RIS | DOI

2010

Teupser Daniel, Baber Ronny, Ceglarek Uta, Scholz Markus, Illig Thomas, Gieger Christian, Holdt Lesca M., Leichtle Alexander, Greiser Karin H., Huster Dominik, Linsel-Nitschke Patrick, Schäfer Arne, Braund Peter S., Tiret Laurence, Stark Klaus, Raaz-Schrauder Dorette, Fiedler Georg M., Wilfert Wolfgang, Beutner Frank, Gielen Stephan, Großhennig Anika, König Inke R., Lichtner Peter, Heid Iris M., Kluttig Alexander, El Mokhtari Nour E., Rubin Diana, Ekici Arif B., Reis André, Garlichs Christoph D., Hall Alistair S., Matthes Gert, Wittekind Christian, Hengstenberg Christian, Cambien Francois, Schreiber Stefan, Werdan Karl, Meitinger Thomas, Loeffler Markus, Samani Nilesh J., Erdmann Jeanette, Wichmann H.-Erich, Schunkert Heribert, Thiery Joachim. Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circulation: Cardiovascular Genetics 2010;3(4):331-339. https://doi.org/10.1161/circgenetics.109.907873 BibTeX | RIS | DOI

Mütze U., Beblo S., Ceglarek U., Brügel M., Kortz L., Fiedler G. M., Leichtle Alexander, Thiery J., Kiess W.. MS78 Monitoring of platelet function and eicosanoid release using LC-MS/MS in patients with phenylketonuria (PKU) [Abstract]. Atherosclerosis Supplements 2010;11(2):125. https://doi.org/10.1016/s1567-5688(10)70579-1 BibTeX | RIS | DOI

Leichtle Alexander Benedikt, Ceglarek Uta, Witzigmann Helmut, Gäbel Gábor, Thiery Joachim, Fiedler Georg Martin. Potential of dried blood self-sampling for cyclosporine-2 monitoring in transplant outpatients. Journal of Transplantation 2010;2010:201918. https://doi.org/10.1155/2010/201918 PDF | BibTeX | RIS | DOI

Fiedler Georg Martin, Ceglarek Uta, Leichtle Alexander, Thiery Joachim. Standardized preprocessing of urine for proteome analysis. In: Rai Alex J., editor. The urinary proteome: methods and protocols. Totowa, NJ: Humana Press; 2010. p. 47-63. https://doi.org/10.1007/978-1-60761-711-2_4 BibTeX | RIS | DOI

2009

Ceglarek Uta, Leichtle Alexander, Brügel Mathias, Kortz Linda, Brauer Romy, Bresler Kristin, Thiery Joachim, Fiedler Georg Martin. Challenges and developments in tandem mass spectrometry based clinical metabolomics. Molecular and Cellular Endocrinology 2009;301(1-2):266-271. https://doi.org/10.1016/j.mce.2008.10.013 BibTeX | RIS | DOI

Walther Claudia, Gaede Luise, Adams Volker, Gelbrich Götz, Leichtle Alexander, Erbs Sandra, Sonnabend Melanie, Fikenzer Kati, Körner Antje, Kiess Wieland, Bruegel Mathias, Thiery Joachim, Schuler Gerhard. Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial. Circulation 2009;120(22):2251-2259. https://doi.org/10.1161/circulationaha.109.865808 BibTeX | RIS | DOI

Ceglarek Uta, Kortz Linda, Leichtle Alexander, Fiedler Georg M., Kratzsch Jürgen, Thiery Joachim. Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography–triple quadrupole linear ion trap mass spectrometry. Clinica Chimica Acta 2009;401(1-2):114-118. https://doi.org/10.1016/j.cca.2008.11.022 BibTeX | RIS | DOI

Fiedler Georg Martin, Leichtle Alexander Benedikt, Kase Julia, Baumann Sven, Ceglarek Uta, Felix Klaus, Conrad Tim, Witzigmann Helmut, Weimann Arved, Schütte Christof, Hauss Johann, Büchler Markus, Thiery Joachim. Serum peptidome profiling revealed platelet factor 4 as a potential discriminating peptide associated with pancreatic cancer. Clinical Cancer Research 2009;15(11):3812-3819. https://doi.org/10.1158/1078-0432.ccr-08-2701 BibTeX | RIS | DOI

Kortz Linda, Geyer Roland, Ludwig Ute, Planert Mathis, Bruegel Mathias, Leichtle Alexander, Fiedler Georg Martin, Thiery Joachim, Ceglarek Uta. Simultaneous eicosanoid profiling and identification by liquid chromatography and hybrid triple quadrupole-linear ion trap mass spectrometry for metabolomic studies in human plasma. LaboratoriumsMedizin 2009;33(6):341-348. https://doi.org/10.1515/jlm.2009.057 PDF | BibTeX | RIS | DOI

Bruegel Mathias, Planert Mathis, Baumann Sven, Focke Almut, Then Bergh Florian, Leichtle Alexander, Ceglarek Uta, Thiery Joachim, Fiedler Georg Martin. Standardized peptidome profiling of human cerebrospinal fluid by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Proteomics 2009;72(4):608-615. https://doi.org/10.1016/j.jprot.2008.11.018 BibTeX | RIS | DOI

2008

Buchbinder S., Kratzsch J., Fiedler G. M., Yar V., Brügel M., Leichtle Alexander, Weber W., Alexander H., Matthes G., Thiery J.. Body weight and oral contraceptives are the most important modulators of serum CRP levels. Scandinavian Journal of Clinical and Laboratory Investigation 2008;68(2):140-144. https://doi.org/10.1080/00365510701487727 BibTeX | RIS | DOI

Busse Franziska, Omidi Leyla, Leichtle Alexander, Windgassen Michael, Kluge Eyleen, Stumvoll Michael. Lead poisoning due to adulterated marijuana [Letter]. New England Journal of Medicine 2008;358(15):1641-1642. https://doi.org/10.1056/nejmc0707784 BibTeX | RIS | DOI

Busse Franziska P., Fiedler Georg Martin, Leichtle Alexander, Hentschel Helmut, Stumvoll Michael. Lead poisoning due to adulterated marijuana in Leipzig. Deutsches Ärzteblatt International 2008;105(44):757-762. https://doi.org/10.3238/arztebl.2008.0757 BibTeX | RIS | DOI

Lobstein S., Kaiser T., Liebert U., Wojan M., Leichtle Alexander, Mössner J., Wiegand J., Tillmann H.. Prevalence, aetiology and associated co-morbidities of elevated aminotransferases in a German cohort of orthopaedic surgery patients. Zeitschrift für Gastroenterologie 2008;46(5):415-420. https://doi.org/10.1055/s-2008-1027157 BibTeX | RIS | DOI

2007

Fiedler Georg Martin, Baumann Sven, Leichtle Alexander, Oltmann Anke, Kase Julia, Thiery Joachim, Ceglarek Uta. Standardized peptidome profiling of human urine by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clinical Chemistry 2007;53(3):421-428. https://doi.org/10.1373/clinchem.2006.077834 BibTeX | RIS | DOI

2006

Leichtle Alexander, Fiedler Georg Martin, Gäbel Gábor, Ceglarek Uta, Baumann Sven, Witzigmann Helmut, Hauss Johann, Thiery Joachim. Abstract 1824: Clinical evaluation of self obtained capillary blood and dried blood spots for cyclosporine C0 and C2 monitoring in transplant recipients [Abstract]. Circulation 2006;114(suppl_18):1824. BibTeX | RIS | URL

Ceglarek Uta, Fiedler Georg Martin, Leichtle Alexander, Baumann Sven, Lang Olga, Loewel Hannelore, Thiery Joachim, Doering Angela. Abstract 4004: Body mass is significantly associated with decreased sterol resorption and increased cholesterol synthesis: results of the population-based MONICA/KORA survey 1994/95 [Abstract]. Circulation 2006;114(suppl_18):II_861. BibTeX | RIS | URL

Thiery Joachim, Ceglarek Uta, Fiedler Georg Martin, Leichtle Alexander, Baumann Sven, Teupser Daniel, Lang Olga, Baumer Jens, Meisinger Christa, Löwel Hannelore, Döring Angela. Abstract 4099: Elevated campesterol serum levels - a significant predictor of incident myocardial infarction: results of the population-based MONICA/KORA follow-up study 1994 to 2005 [Abstract]. Circulation 2006;114(suppl_18):II_884. BibTeX | RIS | URL

Leichtle Alexander, Teupser Daniel, Thiery Joachim. Alpha-tocopherol distribution in lipoproteins and anti-inflammatory effects differ between CHD-patients and healthy subjects. Journal of the American College of Nutrition 2006;25(5):420-428. https://doi.org/10.1080/07315724.2006.10719555 BibTeX | RIS | DOI

Conrad Tim O. F., Leichtle Alexander, Hagehülsmann Andre, Diederichs Elmar, Baumann Sven, Thiery Joachim, Schütte Christof. Beating the noise: new statistical methods for detecting signals in MALDI-TOF spectra below noise level. Berthold Michael R., Glen Robert C., Fischer Ingrid, editors. Computational Life Sciences II: Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006, proceedings Cham: Springer; 2006. 119-128. https://doi.org/10.1007/11875741_12 BibTeX | RIS | DOI

Kratzsch J., Gäbel G., Leichtle Alexander, Otto L., Thiery J.. Is recovery testing a relevant tool to validate the assessment of serum thyroglobulin levels? [Abstract]. Experimental and Clinical Endocrinology & Diabetes 2006;114(S 1):P02_029. https://doi.org/10.1055/s-2006-932915 BibTeX | RIS | DOI

Baumann Sven, Fiedler Georg Martin, Ceglarek Uta, Leichtle Alexander, Mayer Christoph, Stumvoll Michael, Thiery Joachim. MP180 Standardization and evaluation of magnetic bead-based urine proteome profiling with MALDI-TOF MS for the detection of new biomarkers [Abstract]. Nephrology Dialysis Transplantation 2006;21(Supplement 4):iv358. https://doi.org/10.1093/ndt/21.suppl_4.iv355 BibTeX | RIS | DOI

Ceglarek U., Fiedler G. M., Lembeke J., Baumann S., Leichtle Alexander, Döring A., Löwel H., Wichmann E., Thiery J.. Mo-P1:115 Evaluation of plant sterol serum levels in 4222 volunteers of the Monica survey [Abstract]. Atherosclerosis Supplements 2006;7(3):71. https://doi.org/10.1016/s1567-5688(06)80250-3 BibTeX | RIS | DOI

2005

Baumann S., Ceglarek U., Fiedler G., Lembcke J., Leichtle Alexander, Thiery J.. 14.5 Standardization and evaluation of magnetic bead-based proteome profiling with MALDI-TOF-MS for the detection of new biomarkers in human blood [Abstract]. Molecular & Cellular Proteomics 2005;4(8, Supplement 1):S141. https://doi.org/10.1016/S1535-9476(20)34749-6 PDF | BibTeX | RIS | DOI

Ceglarek Uta, Fiedler Georg Martin, Baumann Sven, Lembcke Jan, Leichtle Alexander, Thiery Joachim. Klinische Proteomics – Chance für die Labormedizin?. Laborwelt 2005;6(3):15-16. BibTeX | RIS

Kratzsch Juergen, Fiedler Georg Martin, Leichtle Alexander, Brügel Matthias, Buchbinder Susanne, Otto Lothar, Sabri Osama, Matthes Gert, Thiery Joachim. New reference intervals for thyrotropin and thyroid hormones based on national academy of clinical biochemistry criteria and regular ultrasonography of the thyroid. Clinical Chemistry 2005;51(8):1480-1486. https://doi.org/10.1373/clinchem.2004.047399 BibTeX | RIS | DOI

Lembcke Jan, Ceglarek Uta, Fiedler Georg Martin, Baumann Sven, Leichtle Alexander, Thiery Joachim. Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. Journal of Lipid Research 2005;46(1):21-26. https://doi.org/10.1194/jlr.c400004-jlr200 PDF | BibTeX | RIS | DOI

Baumann Sven, Ceglarek Uta, Fiedler Georg Martin, Lembcke Jan, Leichtle Alexander, Thiery Joachim. Standardized approach to proteome profiling of human serum based on magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clinical Chemistry 2005;51(6):973-980. https://doi.org/10.1373/clinchem.2004.047308 BibTeX | RIS | DOI

2004

Fiedler G. M., Ceglarek U., Lembcke J., Baumann S., Leichtle Alexander, Thiery J.. Anwendungsgebiete der Massenspektrometrie in der Klinischen Chemie und Laboratoriumsmedizin. LaboratoriumsMedizin 2004;28(3):185-194. https://doi.org/10.1515/labmed.2004.027 PDF | BibTeX | RIS | DOI

Kratzsch J., Fiedler G. M., Yar V., Buchbinder S., Kunkel P., Leichtle Alexander, Brügel M., Matthes G., Thiery J.. Evaluation of serum measures of thyroid function and disease in healthy subjects with sonographically assessed thyroid gland [Abstract]. Experimental and Clinical Endocrinology & Diabetes 2004;112(S1):P29. https://doi.org/10.1055/s-2004-819147 BibTeX | RIS | DOI

Lembcke J., Ceglarek U., Fiedler G., Baumann S., Leichtle Alexander, Thiery J.. F10 Rapid quantification of free and esterified phytosterols in serum using atmospheric pressure photoionization liquid chromatography tandem mass spectrometry [Abstract]. Clinical Chemistry and Laboratory Medicine 2004;42(10):A137. https://doi.org/10.1515/cclm.2004.240 BibTeX | RIS | DOI