Prof. Dr. Pascal Johann
Prof. Dr. Pascal Johann
Professor für Experimentelle Pädiatrie
Kinder- und Jugendmedizin
- Telefon: +49 (0) 821 400-9201
Publikationen
2023
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2022
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2021
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2020
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2010
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2023 |
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Kruchen Anne, Johann Pascal-David, Rekowski Laura, Müller Ingo.
Epigenetic modification of mesenchymal stromal cells derived from bone marrow and embryonal tumors to facilitate immunotherapeutic approaches in pediatric malignancies.
https://doi.org/10.3390/cimb45030136
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Kuhlen Michaela, Kunstreich Marina, Wudy Stefan A., Holterhus Paul-Martin, Lessel Lienhard, Schneider Dominik T., Brecht Ines B., Schewe Denis M., Seitz Guido, Roecken Christoph, Vokuhl Christian, Johann Pascal-David, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Outcome for pediatric adreno-cortical tumors is best predicted by the COG stage and five-item microscopic score — report from the German MET studies.
https://doi.org/10.3390/cancers15010225
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Johann Pascal-David, Altendorf Lea, Efremova Emma-Maria, Holsten Till, Steinbügl Mona, Nemes Karolina, Eckhardt Alicia, Kresbach Catena, Bockmayr Michael, Koch Arend, Haberler Christine, Antonelli Manila, DeSisto John, Schuhmann Martin U., Hauser Peter, Siebert Reiner, Bens Susanne, Kool Marcel, Green Adam L., Hasselblatt Martin, Frühwald Michael C., Schüller Ulrich.
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.
https://doi.org/10.1007/s00401-023-02608-7
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Kuhlen Michaela, Kunstreich Marina, Lessel Lienhard, Wudy Stefan A., Holterhus Paul-Martin, Vokuhl Christian, Juettner Eva, Roecken Christoph, Seitz Guido, Slavetinsky Christoph, Fuchs Jörg, Schewe Denis M., Claus Rainer, Johann Pascal-David, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Refractory and relapsed paediatric ACC in the MET studies – a challenging situation necessitating novel diagnostic and therapeutic concepts.
https://doi.org/10.1016/j.ejcped.2023.100015
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Nemes Karolina, Benesch Martin, Kolarova Julia, Johann Pascal-David, Hasselblatt Martin, Thomas Christian, Bens Susanne, Glaser Selina, Ammerpohl Ole, Liaugaudiene Olga, Sadeghipour Alireza, von der Weid Nicolas, Schmid Irene, Gidding Corrie, Erdreich-Epstein Anat, Khurana Claudia, Ebetsberger-Dachs Georg, Lemmer Andreas, Khatib Ziad, Hernández Marqués Carmen, Pears Jane, Quehenberger Franz, Kordes Uwe, Vokuhl Christian, Gerss Joachim, Schwarz Heike, Bison Brigitte, Biegel Jaclyn A., Siebert Reiner, Frühwald Michael C..
Rhabdoid tumors in patients conceived following ART: is there an association?.
https://doi.org/10.1093/humrep/dead154
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2022 |
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Federico Aniello, Thomas Christian, Miskiewicz Katarzyna, Woltering Niklas, Zin Francesca, Nemes Karolina, Bison Brigitte, Johann Pascal-David, Hawes Debra, Bens Susanne, Kordes Uwe, Albrecht Steffen, Dohmen Hildegard, Hauser Peter, Keyvani Kathy, van Landeghem Frank K. H., Lund Eva Løbner, Scheie David, Mawrin Christian, Monoranu Camelia-Maria, Parm Ulhøi Benedicte, Pietsch Torsten, Reinhard Harald, Riemenschneider Markus J., Sehested Astrid, Sumerauer David, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.
https://doi.org/10.1007/s00401-022-02424-5
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Nemes Karolina, Johann Pascal-David, Tüchert Stefanie, Melchior Patrick, Vokuhl Christian, Siebert Reiner, Furtwängler Rhoikos, Frühwald Michael C..
Current and emerging therapeutic approaches for extracranial malignant rhabdoid tumors.
https://doi.org/10.2147/cmar.s289544
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Jurmeister Philipp, Glöß Stefanie, Roller Renée, Leitheiser Maximilian, Schmid Simone, Mochmann Liliana H., Payá Capilla Emma, Fritz Rebecca, Dittmayer Carsten, Friedrich Corinna, Thieme Anne, Keyl Philipp, Jarosch Armin, Schallenberg Simon, Bläker Hendrik, Hoffmann Inga, Vollbrecht Claudia, Lehmann Annika, Hummel Michael, Heim Daniel, Haji Mohamed, Harter Patrick, Englert Benjamin, Frank Stephan, Hench Jürgen, Paulus Werner, Hasselblatt Martin, Hartmann Wolfgang, Dohmen Hildegard, Keber Ursula, Jank Paul, Denkert Carsten, Stadelmann Christine, Bremmer Felix, Richter Annika, Wefers Annika, Ribbat-Idel Julika, Perner Sven, Idel Christian, Chiariotti Lorenzo, Della Monica Rosa, Marinelli Alfredo, Schüller Ulrich, Bockmayr Michael, Liu Jacklyn, Lund Valerie J., Forster Martin, Lechner Matt, Lorenzo-Guerra Sara L., Hermsen Mario, Johann Pascal-David, Agaimy Abbas, Seegerer Philipp, Koch Arend, Heppner Frank, Pfister Stefan M., Jones David T. W., Sill Martin, von Deimling Andreas, Snuderl Matija, Müller Klaus-Robert, Forgó Erna, Howitt Brooke E., Mertins Philipp, Klauschen Frederick, Capper David.
DNA methylation-based classification of sinonasal tumors.
https://doi.org/10.1038/s41467-022-34815-3
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Nemes Karolina, Johann Pascal-David, Steinbügl Mona, Gruhle Miriam, Bens Susanne, Kachanov Denis, Teleshova Margarita, Hauser Peter, Simon Thorsten, Tippelt Stephan, Eberl Wolfgang, Chada Martin, Lopez Vicente Santa-Maria, Grigull Lorenz, Hernáiz-Driever Pablo, Eyrich Matthias, Pears Jane, Milde Till, Reinhard Harald, Leipold Alfred, van de Wetering Marianne, Gil-da-Costa Maria João, Ebetsberger-Dachs Georg, Kerl Kornelius, Lemmer Andreas, Boztug Heidrun, Furtwängler Rhoikos, Kordes Uwe, Vokuhl Christian, Hasselblatt Martin, Bison Brigitte, Kröncke Thomas, Melchior Patrick, Timmermann Beate, Gerss Joachim, Siebert Reiner, Frühwald Michael C..
Infants and newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB registry: a unique and challenging population.
https://doi.org/10.3390/cancers14092185
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Hasselblatt Martin, Thomas Christian, Federico Aniello, Bens Susanne, Hellström Mats, Casar‐Borota Olivera, Kordes Uwe, Neumann Julia E., Dottermusch Matthias, Rodriguez Fausto J., Lo Andrea C., Cheng Sylvia, Hendson Glenda, Hukin Juliette, Hartmann Christian, Koch Arend, Capper David, Siebert Reiner, Paulus Werner, Nemes Karolina, Johann Pascal-David, Frühwald Michael C., Kool Marcel.
Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant: a clinical and histopathological distinct entity showing epigenetic similarity with ATRT‐MYC.
https://doi.org/10.1111/nan.12797
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Blümel Lena, Qin Nan, Berlandi Johannes, Paisana Eunice, Cascão Rita, Custódia Carlos, Pauck David, Picard Daniel, Langini Maike, Stühler Kai, Meyer Frauke-Dorothee, Göbbels Sarah, Malzkorn Bastian, Liebau Max C., Barata João T., Jeibmann Astrid, Kerl Kornelius, Erkek Serap, Kool Marcel, Pfister Stefan M., Johann Pascal-David, Frühwald Michael C., Borkhardt Arndt, Reifenberger Guido, Faria Claudia C., Fischer Ute, Hasselblatt Martin, Bartl Jasmin, Remke Marc.
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1038/s41419-022-05243-4
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Fincke Victoria E., Krulik Mateja E., Joshi Piyush, Frühwald Michael C., Chen Ying-Bei, Johann Pascal-David.
Renal medullary carcinomas harbor a distinct methylation phenotype and display aberrant methylation of genes related to early nephrogenesis.
https://doi.org/10.3390/cancers14205044
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Hasselblatt Martin, Thomas Christian, Federico Aniello, Nemes Karolina, Johann Pascal-David, Bison Brigitte, Bens Susanne, Dahlum Sonja, Kordes Uwe, Redlich Antje, Lessel Lienhard, Pajtler Kristian W., Mawrin Christian, Schüller Ulrich, Nolte Kay, Kramm Christof M., Hinz Felix, Sahm Felix, Giannini Caterina, Penkert Judith, Kratz Christian P., Pfister Stefan M., Siebert Reiner, Paulus Werner, Kool Marcel, Frühwald Michael C..
SMARCB1-deficient and SMARCA4-deficient malignant brain tumors with complex copy number alterations and TP53 mutations may represent the first clinical manifestation of Li-Fraumeni syndrome.
https://doi.org/10.1097/pas.0000000000001905
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Graf Monika, Interlandi Marta, Moreno Natalia, Holdhof Dörthe, Göbel Carolin, Melcher Viktoria, Mertins Julius, Albert Thomas K., Kastrati Dennis, Alfert Amelie, Holsten Till, de Faria Flavia, Meisterernst Michael, Rossig Claudia, Warmuth-Metz Monika, Nowak Johannes, Meyer zu Hörste Gerd, Mayère Chloe, Nef Serge, Johann Pascal-David, Frühwald Michael C., Dugas Martin, Schüller Ulrich, Kerl Kornelius.
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.
https://doi.org/10.1038/s41467-022-29152-4
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Johann Pascal-David.
“Adult rhabdoid tumors—a riddle inside an enigma?”.
https://doi.org/10.1038/s41379-022-01144-1
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2021 |
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Thomas Christian, Federico Aniello, Sill Martin, Bens Susanne, Oyen Florian, Nemes Karolina, Johann Pascal-David, Hartmann Christian, Hartmann Wolfgang, Sumerauer David, Paterno Vincenzo, Samii Amir, Kordes Uwe, Siebert Reiner, Frühwald Michael C., Paulus Werner, Kool Marcel, Hasselblatt Martin.
Atypical teratoid/rhabdoid tumor (AT/RT) with molecular features of pleomorphic xanthoastrocytoma.
https://doi.org/10.1097/pas.0000000000001694
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Steinbügl Mona, Nemes Karolina, Johann Pascal-David, Kröncke Thomas, Tüchert Stefanie, da Costa Maria Joao Gil, Ebinger Martin, Schüller Ulrich, Sehested Astrid, Hauser Peter, Reinhard Harald, Sumerauer David, Hettmer Simone, Jakob Marcus, Hasselblatt Martin, Siebert Reiner, Witt Olaf, Gerss Joachim, Kerl Kornelius, Frühwald Michael C..
Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors.
https://doi.org/10.1002/pbc.29267
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Johann Pascal-David, Wuchter Patrick, Trojanova Lenka, Sturm Dominik, Lu Kevin Hai-Ning, Kulozik Andreas E., Kunz Joachim B..
Cui Bono? Identifying patient groups that may benefit from granulocyte transfusions in pediatric hematology and oncology.
https://doi.org/10.1097/mph.0000000000002349
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Zin Francesca, Cotter Jennifer A., Haberler Christine, Dottermusch Matthias, Neumann Julia, Schüller Ulrich, Schweizer Leonille, Thomas Christian, Nemes Karolina, Johann Pascal-David, Kool Marcel, Frühwald Michael C., Paulus Werner, Judkins Alexander, Hasselblatt Martin.
Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
https://doi.org/10.1111/bpa.12967
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Pathak Rajiv, Zin Francesca, Thomas Christian, Bens Susanne, Gayden Tenzin, Karamchandani Jason, Dudley Roy W., Nemes Karolina, Johann Pascal-David, Oyen Florian, Kordes Uwe, Jabado Nada, Siebert Reiner, Paulus Werner, Kool Marcel, Frühwald Michael C., Albrecht Steffen, Kalpana Ganjam V., Hasselblatt Martin.
Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s00401-021-02328-w
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Marcu Ana, Schlosser Andreas, Keupp Anne, Trautwein Nico, Johann Pascal-David, Wölfl Matthias, Lager Johanna, Monoranu Camelia Maria, Walz Juliane S, Henkel Lisa M, Krauß Jürgen, Ebinger Martin, Schuhmann Martin, Thomale Ulrich Wilhelm, Pietsch Torsten, Klinker Erdwine, Schlegel Paul G, Oyen Florian, Reisner Yair, Rammensee Hans-Georg, Eyrich Matthias.
Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
https://doi.org/10.1136/jitc-2021-003404
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Johann Pascal-David, Lenz Dominic, Ries Markus.
The drug development pipeline for glioblastoma: a cross sectional assessment of the FDA orphan drug product designation database.
https://doi.org/10.1371/journal.pone.0252924
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van Tilburg Cornelis M., Pfaff Elke, Pajtler Kristian W., Langenberg Karin P. S., Fiesel Petra, Jones Barbara C., Balasubramanian Gnana Prakash, Stark Sebastian, Johann Pascal-David, Blattner-Johnson Mirjam, Schramm Kathrin, Dikow Nicola, Hirsch Steffen, Sutter Christian, Grund Kerstin, von Stackelberg Arend, Kulozik Andreas E., Lissat Andrej, Borkhardt Arndt, Meisel Roland, Reinhardt Dirk, Klusmann Jan-Henning, Fleischhack Gudrun, Tippelt Stephan, von Schweinitz Dietrich, Schmid Irene, Kramm Christof M., von Bueren Andre O., Calaminus Gabriele, Vorwerk Peter, Graf Norbert, Westermann Frank, Fischer Matthias, Eggert Angelika, Burkhardt Birgit, Wossmann Wilhelm, Nathrath Michaela, Hecker-Nolting Stefanie, Frühwald Michael C., Schneider Dominik T., Brecht Ines B, Ketteler Petra, Fulda Simone, Koscielniak Ewa, Meister Michael T., Scheer Monika, Hettmer Simone, Schwab Matthias, Tremmel Roman, Ora Ingrid, Hutter Caroline, Gerber Nicolas U., Lohi Olli, Kazanowska Bernarda, Kattamis Antonis, Filippidou Maria, Goemans Bianca, Zwaan C. Michel, Milde Till, Jager Natalie, Wolf Stephan, Reuss David, Sahm Felix, von Deimling Andreas, Dirksen Uta, Freitag Angelika, Witt Ruth, Lichter Peter, Kopp-Schneider Annette, Jones David T. W., Molenaar Jan J., Capper David, Pfister Stefan M., Witt Olaf.
The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets.
https://doi.org/10.1158/2159-8290.cd-21-0094
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2020 |
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Bremer Juliane, Kottke Raimund, Johann Pascal-David, Hoff Katja, Brazzola Pierluigi, Grotzer Michael A., Kool Marcel, Rushing Elisabeth, Gerber Nicolas U..
A single supratentorial high‐grade neuroepithelial tumor with two distinct BCOR mutations, exceptionally long complete remission and survival.
https://doi.org/10.1002/pbc.28384
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Holdhof Dörthe, Johann Pascal-David, Spohn Michael, Bockmayr Michael, Safaei Sepehr, Joshi Piyush, Masliah-Planchon Julien, Ho Ben, Andrianteranagna Mamy, Bourdeaut Franck, Huang Annie, Kool Marcel, Upadhyaya Santhosh A., Bendel Anne E., Indenbirken Daniela, Foulkes William D., Bush Jonathan W., Creytens David, Kordes Uwe, Frühwald Michael C., Hasselblatt Martin, Schüller Ulrich.
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
https://doi.org/10.1007/s00401-020-02250-7
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Thomas Christian, Wefers Annika, Bens Susanne, Nemes Karolina, Agaimy Abbas, Oyen Florian, Vogelgesang Silke, Rodriguez Fausto J., Brett Francesca M., McLendon Roger, Bodi Istvan, Burel-Vandenbos Fanny, Keyvani Kathy, Tippelt Stefan, Poulsen Frantz R., Lipp Eric S., Giannini Caterina, Reifenberger Guido, Kuchelmeister Klaus, Pietsch Torsten, Kordes Uwe, Siebert Reiner, Frühwald Michael C., Johann Pascal-David, Sill Martin, Kool Marcel, Deimling Andreas von, Paulus Werner, Hasselblatt Martin.
Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults.
https://doi.org/10.1007/s00401-019-02094-w
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Johann Pascal-David.
Invited review: dysregulation of chromatin remodellers in paediatric brain tumours – SMARCB1 and beyond.
https://doi.org/10.1111/nan.12616
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Theruvath Johanna, Sotillo Elena, Mount Christopher W., Graef Claus Moritz, Delaidelli Alberto, Heitzeneder Sabine, Labanieh Louai, Dhingra Shaurya, Leruste Amaury, Majzner Robbie G., Xu Peng, Mueller Sabine, Yecies Derek W., Finetti Martina A., Williamson Daniel, Johann Pascal-David, Kool Marcel, Pfister Stefan, Hasselblatt Martin, Frühwald Michael C., Delattre Olivier, Surdez Didier, Bourdeaut Franck, Puget Stephanie, Zaidi Sakina, Mitra Siddhartha S., Cheshier Samuel, Sorensen Poul H., Monje Michelle, Mackall Crystal L..
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1038/s41591-020-0821-8
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Kuwahara Yasumichi, Iehara Tomoko, Ichise Eisuke, Katsumi Yoshiki, Ouchi Kazutaka, Tsuchiya Kunihiko, Miyachi Mitsuru, Konichi Eiichi, Sasajima Hiroyasu, Nakamura Satoaki, Fumino Shigehisa, Tajiri Tatsuro, Johann Pascal-David, Frühwald Michael C., Yoshida Tatsushi, Okuda Tsukasa, Hosoi Hajime.
Novel two MRT cell lines established from multiple sites of a synchronous MRT patient.
https://doi.org/10.21873/anticanres.14636
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Hasselblatt M., Thomas C., Nemes K., Monoranu C.‐M., Riemenschneider M. J., Koch A., Sumerauer D., Hauser P., Paulus W., Johann Pascal-David, Kool M., Frühwald Michael C..
Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT‐TYR).
https://doi.org/10.1111/nan.12560
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2019 |
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Frühwald Michael C., Hasselblatt Martin, Nemes Karolina, Bens Susanne, Steinbügl Mona, Johann Pascal-David, Kerl Kornelius, Hauser Peter, Quiroga Eduardo, Solano-Paez Palma, Biassoni Veronica, Gil-da-Costa Maria Joao, Perek-Polnik Martha, van de Wetering Marianne, Sumerauer David, Pears Jane, Stabell Niklas, Holm Stefan, Hengartner Heinz, Gerber Nicolas U., Grotzer Michael, Boos Joachim, Ebinger Martin, Tippelt Stefan, Paulus Werner, Furtwängler Rhoikos, Hernáiz-Driever Pablo, Reinhard Harald, Rutkowski Stefan, Schlegel Paul-Gerhardt, Schmid Irene, Kortmann Rolf-Dieter, Timmermann Beate, Warmuth-Metz Monika, Kordes Uwe, Gerss Joachim, Nysom Karsten, Schneppenheim Reinhard, Siebert Reiner, Kool Marcel, Graf Norbert.
Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors.
https://doi.org/10.1093/neuonc/noz244
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Erkek Serap, Johann Pascal-David, Finetti Martina A., Drosos Yiannis, Chou Hsien-Chao, Zapatka Marc, Sturm Dominik, Jones David T. W., Korshunov Andrey, Rhyzova Marina, Wolf Stephan, Mallm Jan-Philipp, Beck Katja, Witt Olaf, Kulozik Andreas E., Frühwald Michael C., Northcott Paul A., Korbel Jan O., Lichter Peter, Eils Roland, Gajjar Amar, Roberts Charles W. M., Williamson Daniel, Hasselblatt Martin, Chavez Lukas, Pfister Stefan M., Kool Marcel.
Comprehensive analysis of chromatin states in atypical teratoid/rhabdoid tumor identifies diverging roles for SWI/SNF and polycomb in gene regulation.
https://doi.org/10.1016/j.ccell.2018.11.014
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Tegeder Isabel, Thiel Katharina, Erkek Serap, Johann Pascal-David, Berlandi Johannes, Thatikonda Venu, Frühwald Michael C., Kool Marcel, Jeibmann Astrid, Hasselblatt Martin.
Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s11060-018-03018-6
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Bleeke Matthias, Johann Pascal-David, Gröbner Susanne, Alten Julia, Cario Gunnar, Schäfer Hansjörg, Klapper Wolfram, Khoury Joseph, Pfister Stefan, Müller Ingo.
Genome‐wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients.
https://doi.org/10.1002/pbc.28074
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Chun Hye-Jung E., Johann Pascal-David, Milne Katy, Zapatka Marc, Buellesbach Annette, Ishaque Naveed, Iskar Murat, Erkek Serap, Wei Lisa, Tessier-Cloutier Basile, Lever Jake, Titmuss Emma, Topham James T., Bowlby Reanne, Chuah Eric, Mungall Karen L., Ma Yussanne, Mungall Andrew J., Moore Richard A., Taylor Michael D., Gerhard Daniela S., Jones Steven J. M., Korshunov Andrey, Gessler Manfred, Kerl Kornelius, Hasselblatt Martin, Frühwald Michael C., Perlman Elizabeth J., Nelson Brad H., Pfister Stefan M., Marra Marco A., Kool Marcel.
Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration.
https://doi.org/10.1016/j.celrep.2019.10.013
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Ho Ben, Johann Pascal-David, Grabovska Yura, De Dieu Andrianteranagna Mamy Jean, Yao Fupan, Frühwald Michael C., Hasselblatt Martin, Bourdeaut Franck, Williamson Daniel, Huang Annie, Kool Marcel.
Molecular subgrouping of atypical teratoid/rhabdoid tumors: a reinvestigation and current consensus.
https://doi.org/10.1093/neuonc/noz235
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Johann Pascal-David, Jäger Natalie, Pfister Stefan M., Sill Martin.
RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression.
https://doi.org/10.1186/s12859-019-3014-z
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Thomas Christian, Knerlich-Lukoschus Friederike, Reinhard Harald, Johann Pascal-David, Sturm Dominik, Sahm Felix, Bens Susanne, Vogt Julia, Nemes Karolina, Oyen Florian, Kordes Uwe, Siebert Reiner, Schneppenheim Reinhard, Messing-Jünger Martina, Pietsch Torsten, von Deimling Andreas, Paulus Werner, Pfister Stefan M., Kool Marcel, Frühwald Michael C., Hasselblatt Martin.
Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1.
https://doi.org/10.1007/s00401-019-02001-3
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2018 |
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Galarza Natalia Moreno, Holdhof Dörthe, Interlandi Marta, Melcher Viktoria, Graf Monika, Kastrati Dennis, Meisterernst Michael, Johann Pascal-David, Kool Marcel, Frühwald Michael C., Schüller Ulrich, Kerl Kornelius.
ATRT-07. Murine Sox2-positive early precursor cells give rise to rhabdoid tumors with features of the human ATRT-MYC group.
https://doi.org/10.1093/neuonc/noy059.006
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Marcu Ana, Trautwein Nico, Stevanovic Stefan, Johann Pascal-David, Technau Antje, Lager Johanna, Monoranu Camelia-Maria, Henkel Lisa, Krauß Jürgen, Ebinger Martin, Schuhmann Martin, Thomale Ulrich, Pietsch Torsten, Wölfl Matthias, Schlegel Paul Gerhardt, Frühwald Michael C., Oyen Florian, Reisner Yair, Rammensee Hans-Georg, Eyrich Matthias.
IMMU-28. Deciphering the AT/RT ligandome.
https://doi.org/10.1093/neuonc/noy059.344
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Johann Pascal-David, Bens S., Oyen F., Wagener R., Giannini C., Perry A., Raisanen J. M., Reis G. F., Nobusawa S., Arita K., Felsberg J., Reifenberger G., Agaimy A., Buslei R., Capper D., Pfister S. M., Schneppenheim R., Siebert R., Frühwald Michael C., Paulus W., Kool M., Hasselblatt M..
Sellar region atypical teratoid/rhabdoid tumors (ATRT) in adults display DNA methylation profiles of the ATRT-MYC subgroup.
https://doi.org/10.1097/PAS.0000000000001023
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Gröbner Susanne N., Worst Barbara C., Weischenfeldt Joachim, Buchhalter Ivo, Kleinheinz Kortine, Rudneva Vasilisa A., Johann Pascal-David, Balasubramanian Gnana Prakash, Segura-Wang Maia, Brabetz Sebastian, Bender Sebastian, Hutter Barbara, Sturm Dominik, Pfaff Elke, Hübschmann Daniel, Zipprich Gideon, Heinold Michael, Eils Jürgen, Lawerenz Christian, Erkek Serap, Lambo Sander, Waszak Sebastian, Blattmann Claudia, Borkhardt Arndt, Kuhlen Michaela, Eggert Angelika, Fulda Simone, Gessler Manfred, Wegert Jenny, Kappler Roland, Baumhoer Daniel, Burdach Stefan, Kirschner-Schwabe Renate, Kontny Udo, Kulozik Andreas E., Lohmann Dietmar, Hettmer Simone, Eckert Cornelia, Bielack Stefan, Nathrath Michaela, Niemeyer Charlotte, Richter Günther H., Schulte Johannes, Siebert Reiner, Westermann Frank, Molenaar Jan J., Vassal Gilles, Witt Hendrik, Burkhardt Birgit, Kratz Christian P., Witt Olaf, van Tilburg Cornelis M., Kramm Christof M., Fleischhack Gudrun, Dirksen Uta, Rutkowski Stefan, Frühwald Michael C., von Hoff Katja, Wolf Stephan, Klingebiel Thomas, Koscielniak Ewa, Landgraf Pablo, Koster Jan, Resnick Adam C., Zhang Jinghui, Liu Yanling, Zhou Xin, Waanders Angela J., Zwijnenburg Danny A., Raman Pichai, Brors Benedikt, Weber Ursula D., Northcott Paul A., Pajtler Kristian W., Kool Marcel, Piro Rosario M., Korbel Jan O., Schlesner Matthias, Eils Roland, Jones David T. W., Lichter Peter, Chavez Lukas, Zapatka Marc, Pfister Stefan M..
The landscape of genomic alterations across childhood cancers.
https://doi.org/10.1038/nature25480
PDF | BibTeX | RIS | DOI Correction (2018): Nature 559, E10, DOI: 10.1038/s41586-018-0167-2 |
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2017 |
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Johann Pascal-David, Hovestadt Volker, Thomas Christian, Jeibmann Astrid, Heß Katharina, Bens Susanne, Oyen Florian, Hawkins Cynthia, Pierson Christopher R., Aldape Kenneth, Kim Sang-Pyo, Widing Eva, Sumerauer David, Hauser Péter, van Landeghem Frank, Ryzhova Marina, Korshunov Andrey, Capper David, Jones David T.W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome.
https://doi.org/10.1111/bpa.12413
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Hasselblatt Martin, Johann Pascal-David, Kool Marcel, Frühwald Michael C..
Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
https://doi.org/10.1007/s00401-017-1766-y
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Jeibmann Astrid, Schulz Jacqueline, Eikmeier Kristin, Johann Pascal-David, Thiel Katharina, Tegeder Isabel, Ambrée Oliver, Frühwald Michael C., Pfister Stefan M., Kool Marcel, Paulus Werner, Hasselblatt Martin.
SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s11060-016-2326-3
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2016 |
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Thomas Christian, Hovestadt Volker, Schrimpf Daniel, Johann Pascal-David, Bens Susanne, Oyen Florian, Vogel Hannes, Giangaspero Felice, Antonelli Manila, Riemenschneider Markus, Bernardo Marie Christine, Giannini Caterina, Din Nasir Ud, Perry Arie, Keyvani Kathy, van Landeghem Frank, Sumerauer David, Hauser Peter, Capper David, Korshunov Andrey, Jones David T. W., Pfister Stefan, Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
AT-10: atypical teratoid rhabdoid tumors and poorly differentiated chordomas: distinct molecular entities with SMARCB1/INI1 loss and dismal prognosis.
https://doi.org/10.1093/neuonc/now065.09
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Hasselblatt Martin, Thomas Christian, Heß Katharina, Hovestadt Volker, Johann Pascal-David, Bens Susanne, Oyen Florian, Hawkins Cynthia, Pierson Christopher R., Aldape Kenneth, Kim Sang Pyo, Widing Eva, Capper David, Jones David T.W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel.
AT-11: cribriform neuroepithelial tumor (crinet): molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome.
https://doi.org/10.1093/neuonc/now065.10
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Johann Pascal-David, Erkek Serap, Zapatka Marc, Kerl Kornelius, Buchhalter Ivo, Hovestadt Volker, Jones David T. W., Sturm Dominik, Hermann Carl, Segura Wang Maia, Korshunov Andrey, Rhyzova Marina, Gröbner Susanne, Brabetz Sebastian, Chavez Lukas, Bens Susanne, Gröschel Stefan, Kratochwil Fabian, Wittmann Andrea, Sieber Laura, Geörg Christina, Wolf Stefan, Beck Katja, Oyen Florian, Capper David, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Deimling Andreas von, Milde Till, Witt Olaf, Kulozik Andreas E., Ebinger Martin, Shalaby Tarek, Grotzer Michael, Sumerauer David, Zamecnik Josef, Mora Jaume, Jabado Nada, Taylor Michael D., Huang Annie, Aronica Eleonora, Bertoni Anna, Radlwimmer Bernhard, Pietsch Torsten, Schüller Ulrich, Schneppenheim Reinhard, Northcott Paul A., Korbel Jan O., Siebert Reiner, Frühwald Michael C., Lichter Peter, Eils Roland, Gajjar Amar, Hasselblatt Martin, Pfister Stefan M., Kool Marcel.
Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes.
https://doi.org/10.1016/j.ccell.2016.02.001
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Erkek Serap, Johann Pascal-David, Kerl Kornelius, Finetti Martina, Zapatka Marc, Frühwald Michael C., Chavez Lukas, Gajjar Amar, Williamson Daniel, Hasselblatt Martin, Pfister Stefan M., Kool Marcel.
GENT-28: the epigenetic landscape of atypical teratoid/rhabdoid tumors reveals a repressed methylome and epigenetic switches at SMARCB1 binding sites.
https://doi.org/10.1093/neuonc/now212.334
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Sturm Dominik, Orr Brent A., Toprak Umut H., Hovestadt Volker, Jones David T.W., Capper David, Sill Martin, Buchhalter Ivo, Northcott Paul A., Leis Irina, Ryzhova Marina, Koelsche Christian, Pfaff Elke, Allen Sariah J., Balasubramanian Gnanaprakash, Worst Barbara C., Pajtler Kristian W., Brabetz Sebastian, Johann Pascal-David, Sahm Felix, Reimand Jüri, Mackay Alan, Carvalho Diana M., Remke Marc, Phillips Joanna J., Perry Arie, Cowdrey Cynthia, Drissi Rachid, Fouladi Maryam, Giangaspero Felice, Łastowska Maria, Grajkowska Wiesława, Scheurlen Wolfram, Pietsch Torsten, Hagel Christian, Gojo Johannes, Lötsch Daniela, Berger Walter, Slavc Irene, Haberler Christine, Jouvet Anne, Holm Stefan, Hofer Silvia, Prinz Marco, Keohane Catherine, Fried Iris, Mawrin Christian, Scheie David, Mobley Bret C., Schniederjan Matthew J., Santi Mariarita, Buccoliero Anna M., Dahiya Sonika, Kramm Christof M., von Bueren André O., von Hoff Katja, Rutkowski Stefan, Herold-Mende Christel, Frühwald Michael C., Milde Till, Hasselblatt Martin, Wesseling Pieter, Rößler Jochen, Schüller Ulrich, Ebinger Martin, Schittenhelm Jens, Frank Stephan, Grobholz Rainer, Vajtai Istvan, Hans Volkmar, Schneppenheim Reinhard, Zitterbart Karel, Collins V. Peter, Aronica Eleonora, Varlet Pascale, Puget Stephanie, Dufour Christelle, Grill Jacques, Figarella-Branger Dominique, Wolter Marietta, Schuhmann Martin U., Shalaby Tarek, Grotzer Michael, van Meter Timothy, Monoranu Camelia-Maria, Felsberg Jörg, Reifenberger Guido, Snuderl Matija, Forrester Lynn Ann, Koster Jan, Versteeg Rogier, Volckmann Richard, van Sluis Peter, Wolf Stephan, Mikkelsen Tom, Gajjar Amar, Aldape Kenneth, Moore Andrew S., Taylor Michael D., Jones Chris, Jabado Nada, Karajannis Matthias A., Eils Roland, Schlesner Matthias, Lichter Peter, Deimling Andreas von, Pfister Stefan M., Ellison David W., Korshunov Andrey, Kool Marcel.
New brain tumor entities emerge from molecular classification of CNS-PNETs.
https://doi.org/10.1016/j.cell.2016.01.015
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Hasselblatt Martin, Thomas Christian, Hovestadt Volker, Schrimpf Daniel, Johann Pascal-David, Bens Susanne, Oyen Florian, Peetz-Dienhart Susanne, Crede Yvonne, Wefers Annika, Vogel Hannes, Riemenschneider Markus J., Antonelli Manila, Giangaspero Felice, Bernardo Marie Christine, Giannini Caterina, Ud Din Nasir, Perry Arie, Keyvani Kathy, van Landeghem Frank, Sumerauer David, Hauser Peter, Capper David, Korshunov Andrey, Jones David T. W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C., Kool Marcel.
Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.
https://doi.org/10.1007/s00401-016-1574-9
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2015 |
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Johann Pascal-David, Müller Ingo.
Multipotent mesenchymal stromal cells: possible culprits in solid tumors?.
https://doi.org/10.1155/2015/914632
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Jeibmann A., Schulz J., Thiel K., Tegeder I., Johann Pascal-David, Kool M., Paulus W., Frühwald Michael C., Hasselblatt M..
TGF-BETA signaling is involved in the detrimental effects of smarcb1 deficiency in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1002/pbc.25715
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2014 |
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Johann Pascal-David, Korshunov A., Ryzhova M., Kerl K., Milde T., Witt O., Jones D. T. W., Hovestadt V., Gajjar A., Hasselblatt M., Frühwald Michael C., Pfister S., Kool M..
Atypical teratoid/rhabdoid tumour is a heterogeneous entity that comprises subgroups with distinct molecular profiles.
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Johann Pascal-David, Korshunov Andrey, Kerl Kornelius, Huang Annie, Jabado Nada, Hasselblatt Martin, Frühwald Michael C., Pfister Stefan, Kool Marcel.
CNS AT/RTs are a heterogeneous entity that comprises subgroups with distinct molecular profiles.
https://doi.org/10.1016/j.cancergen.2014.09.011
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Hasselblatt M., Jeibmann A., Eikmeier K., Linge A., Johann Pascal-David, Koos B., Bartelheim K., Kool M., Pfister S. M., Frühwald Michael C., Paulus W..
Hippo signaling is essential for the phenotype associated with SNR1 loss in drosophila melanogaster and involved in the biology of SMARCB1-deficient atypical teratoid/rhabdoid tumors.
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2013 |
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Bender Sebastian, Tang Yujie, Lindroth Anders M., Hovestadt Volker, Jones David T.W., Kool Marcel, Zapatka Marc, Northcott Paul A., Sturm Dominik, Wang Wei, Radlwimmer Bernhard, Højfeldt Jonas W., Truffaux Nathalène, Castel David, Schubert Simone, Ryzhova Marina, Şeker-Cin Huriye, Gronych Jan, Johann Pascal-David, Stark Sebastian, Meyer Jochen, Milde Till, Schuhmann Martin, Ebinger Martin, Monoranu Camelia-Maria, Ponnuswami Anitha, Chen Spenser, Jones Chris, Witt Olaf, Collins V. Peter, von Deimling Andreas, Jabado Nada, Puget Stephanie, Grill Jacques, Helin Kristian, Korshunov Andrey, Lichter Peter, Monje Michelle, Plass Christoph, Cho Yoon-Jae, Pfister Stefan M..
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
https://doi.org/10.1016/j.ccr.2013.10.006
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2012 |
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Döring Michaela, Müller Carsten, Johann Pascal-David, Erbacher Annika, Kimmig Astrid, Schwarze Carl-Philipp, Lang Peter, Handgretinger Rupert, Müller Ingo.
Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation.
https://doi.org/10.1186/1471-2334-12-263
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2010 |
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Johann Pascal-David, Vaegler Martin, Gieseke Friederike, Mang Philippa, Armeanu-Ebinger Sorin, Kluba Torsten, Handgretinger Rupert, Müller Ingo.
Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity.
https://doi.org/10.1186/1471-2407-10-501
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