Prof. Dr. Dorothea Weckermann

2023 | 2022 | 2020 | 2018 | 2015 | 2014 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986

2023

Rinscheid Andreas, Gäble Alexander, Wienand Georgine, Pfob Christian, Dierks Alexander, Kircher Malte, Trepel Martin, Weckermann Dorothea, Lapa Constantin, Bundschuh Ralph A.. An intrapatient dosimetry comparison of 177 Lu-rhPSMA-10.1 and 177 Lu-PSMA-I&T in patients with metastatic castration-resistant prostate cancer. https://doi.org/10.2967/jnumed.123.265970
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2022

Kranz Jennifer, Weckermann Dorothea. Genderaspekte in der Urologie. https://doi.org/10.1007/s00120-022-01930-4
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Gakis Georgios, Weckermann Dorothea. Geschlechtsassoziierte Unterschiede beim Harnblasenkarzinom. https://doi.org/10.1007/s00120-022-01914-4
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Maccagno Andrea, Grosser Bianca, Füzesi László, Konukiewitz Björn, Vlasenko Dmytro, Weckermann Dorothea, Raab Stephan, Zenk Johannes, Agaimy Abbas, Märkl Bruno. IgG4-related pseudotumours: a series of 12 cases and a review of the literature. https://doi.org/10.1016/j.pathol.2021.11.015
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2020

Pallauf Maximilian, Hempel Marie C., Hupe Marie C., May Matthias, Haccius Marlene, Weckermann Dorothea, Lebentrau Steffen, Hoschke Bernd, Necknig Ulrike, Pfitzenmaier Jesco, Manka Lukas, Nuhn Philipp, Törzsök Peter, Lusuardi Lukas, Merseburger Axel S.. Adherence to the EAU guideline recommendations for local tumor treatment in penile cancer: results of the European PROspective Penile cancer Study group survey (E-PROPS). https://doi.org/10.1007/s12325-020-01514-8
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2018

Necknig U., Borowitz R., Wöhr M., Leyh H., Weckermann Dorothea. Wie wird der Berufsalltag von Weiterbildungsassistenten in der Urologie in Deutschland bewertet: eine Fragebogenanalyse. https://doi.org/10.1007/s00120-018-0674-7
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2015

Polzer Bernhard, Guzvic Miodrag, Ganzer Roman, Weckermann Dorothea, Braun Bernhard, Appel Inka, Obradovic Milan, Lieb, geb. Huppert Verena Karola, Klein Christoph A.. Identification and molecular characterization of different subpopulations of EpCAM-positive single disseminated cancer cells in prostate cancer.
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2014

Weckermann Dorothea. Re: Metformin use and all-cause and prostate cancer–specific mortality among men with diabetes. https://doi.org/10.1016/j.eururo.2014.03.037
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2012

Gužvić Miodrag, Polzer Bernhard, Ganzer Roman, Weckermann Dorothea, Braun Bernhard, Appel Inka, Maneck Matthias, Wieland Wolfgang, Klein Christoph A.. Identification and molecular characterization of single disseminated metastasis progenitor cells in prostate cancer: the significance of EpCAM-positive cells [Abstract]. https://doi.org/10.1158/1538-7445.prca2012-a63
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Weckermann Dorothea. Re: Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. https://doi.org/10.1016/j.eururo.2012.04.011
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2011

Winter A., Vogt C., Weckermann Dorothea, Wawroschek F.. Komplikationsrate der pelvinen Lymphadenektomie beim klinisch lokalisierten Prostatakarzinom: unterschiedliche Techniken im Vergleich und Abhängigkeit von der Anzahl entfernter Lymphknoten. https://doi.org/10.1055/s-0031-1271389
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Weckermann Dorothea. Priapismus. https://doi.org/10.1007/bf03368858
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2010

Weckermann Dorothea. RANKL-Inhibition beim Prostatakarzinom. https://doi.org/10.1007/bf03369595
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2009

Rotter Ch., Fretschner M., Weckermann Dorothea. Alternative Therapieverfahren bei der BPH: interstitielle Laserkoagulation und transurethrale Mikrowellen-Thermotherapie im Vergleich zur TUR. https://doi.org/10.1515/bmte.1994.39.s1.394
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Weckermann Dorothea, Polzer Bernhard, Ragg Thomas, Blana Andreas, Schlimok Günter, Arnholdt Hans, Bertz Simone, Harzmann Rolf, Klein Christoph A.. Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. https://doi.org/10.1200/jco.2008.17.0563
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Weckermann Dorothea, Forst Helmuth, Polzer Bernhard, Klein Christoph A.. Reply to J. Moss and R. J. Israel. https://doi.org/10.1200/jco.2009.23.7990
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Weckermann Dorothea. Steht ein Strategiewechsel bevor?. https://doi.org/10.1007/bf03369286
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Holl G., Dorn R., Wengenmair H., Weckermann Dorothea, Sciuk J.. Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients. https://doi.org/10.1007/s00259-009-1157-2
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2008

Weckermann Dorothea, Harzmann R.. Belastungssonographie des oberen Harntraktes. https://doi.org/10.1055/s-2007-1011703
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Weckermann Dorothea, Thalgott Mark, Holl Gabriele, Wagner Theodor, Harzmann Rolf. Radioguided surgery in urological malignancies. https://doi.org/10.4103/0970-1591.38595
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Winter Alexander, Vogt Harry, Weckermann Dorothea, Harzmann Rolf, Wawroschek Friedhelm. Sentinel lymph node biopsy in prostatic cancer. https://doi.org/10.1007/978-0-387-38327-9_15
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Harzmann R., Weckermann Dorothea. Ultraschallkontrollierte perkutane Nierenbiopsie. https://doi.org/10.1055/s-2007-1011950
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2007

Mecklenburg Ingo, Weckermann Dorothea, Zippelius Alfred, Schoberth Alexandra, Petersen Stephanie, Prang Nadja, Riethmüller Gert, Kufer Peter. A multimarker real-time RT-PCR for MAGE-A gene expression allows sensitive detection and quantification of the minimal systemic tumor load in patients with localized cancer. https://doi.org/10.1016/j.jim.2007.04.006
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Weckermann Dorothea, Polzer B., Klein C.. Bedeutung Cytokeratin-positiver Zellen im Knochenmark bei Patienten mit klinisch organbegrenztem Prostatakarzinom. https://doi.org/10.1007/s00120-007-1432-4
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Weckermann Dorothea. Editorial Comment on: Detection rate and operating time required for γ probe-guided sentinel lymph node resection after injection of technetium-99m nanocolloid into the prostate with and without preoperative imaging. https://doi.org/10.1016/j.eururo.2007.01.051
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Weckermann Dorothea, Dorn Robert, Holl Gabriele, Wagner Theodor, Harzmann Rolf. Limitations of radioguided surgery in high-risk prostate cancer. https://doi.org/10.1016/j.eururo.2006.08.049
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Weckermann Dorothea, Goppelt Markus, Dorn Robert, Wagner Theodor, Harzmann Rolf. Lymph node metastases detected by radioguided surgery and their influence on PSA progression free survival after radical prostatectomy. https://doi.org/10.1016/s0022-5347(18)31359-4
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Weckermann Dorothea, Holl Gabriele, Dorn Robert, Wagner Theodor, Harzmann Rolf. Reliability of preoperative diagnostics and location of lymph node metastases in presumed unilateral prostate cancer. https://doi.org/10.1111/j.1464-410x.2007.06791.x
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Weckermann Dorothea, Dorn Robert, Trefz M., Wagner Theodor, Wawroschek Friedhelm, Harzmann Rolf. Sentinel lymph node dissection for prostate cancer: experience with more than 1,000 patients. https://doi.org/10.1016/j.juro.2006.10.074
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Weckermann Dorothea, Holl G., Wagner T., Harzmann R. Sentinel-Lymphadenektomie beim Prostatakarzinom: aktueller Stand. https://doi.org/10.1007/s00120-007-1564-6
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2006

Oberneder Ralf, Weckermann Dorothea, Ebner Beatrice, Quadt Cornelia, Kirchinger Petra, Raum Tobias, Locher Mathias, Prang Nadja, Baeuerle Patrick A., Leo Eugen. A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients. https://doi.org/10.1016/j.ejca.2006.05.029
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Weckermann Dorothea, Goppelt Marcus, Dorn Robert, Wawroschek Friedhelm, Harzmann Rolf. Incidence of positive pelvic lymph nodes in patients with prostate cancer, a prostate-specific antigen (PSA) level of ≤10 ng/mL and biopsy Gleason score of ≤6, and their influence on PSA progression-free survival after radical prostatectomy. https://doi.org/10.1111/j.1464-410X.2006.06166.x
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Weckermann Dorothea, Hamm M., Dorn R., Wagner T., Wawroschek F., Harzmann R.. Sentinel-Lymphadenektomie beim Prostatakarzinom: Erfahrungen nach über 800 Eingriffen. https://doi.org/10.1007/s00120-006-1030-x
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Weckermann Dorothea, Dorn Robert, Gronau Eckart, Wagner Theodor, Harzmann Rolf. The sentinel lymph node concept in prostate cancer: experiences after more than 6 years. https://doi.org/10.1016/s0022-5347(18)33602-4
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2005

Gronau E., Arnholdt H., Harzmann R., Weckermann Dorothea. Das Schwannom der Niere: eine seltene Differenzialdiagnose renaler Raumforderungen. https://doi.org/10.1007/s00120-005-0858-9
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Weckermann Dorothea, Wawroschek Friedhelm, Harzmann Rolf. Is there a need for pelvic lymph node dissection in low risk prostate cancer patients prior to definitive local therapy?. https://doi.org/10.1016/j.eururo.2004.07.017
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Gronau Eckart, Goppelt Marcus, Harzmann Rolf, Weckermann Dorothea. Prostate cancer relapse after therapy with curative intention: a diagnostic and therapeutic dilemma. https://doi.org/10.1159/000085661
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Weckermann Dorothea. Reply to Ph. Weston, B.-E. Persson. https://doi.org/10.1016/j.eururo.2004.11.016
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Weckermann Dorothea, Harzmann R.. Schmerztherapie bei urologischen Tumoren - Prophylaxe und Therapie der Nebenwirkungen. https://doi.org/10.1055/s-2004-830208
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Gronau Eckart, Weckermann Dorothea, Harzmann Rolf. Sentinel lymph node resection in prostate cancer patients with PSA higher than 20 NG/ML. https://doi.org/10.1016/s0022-5347(18)35735-5
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Wawroschek F., Harzmann R., Weckermann Dorothea. Wertigkeit der Sentinel-Lymphknotenbiopsie bei urologischen Tumoren. https://doi.org/10.1007/s00120-005-0834-4
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2004

Weckermann Dorothea, Harzmann Rolf. Hormone therapy in prostate cancer: LHRH antagonists versus LHRH analogues. https://doi.org/10.1016/j.eururo.2004.05.006
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Weckermann Dorothea. Langzeit-Hormontherapie beim Prostatakarzinom - Hohe Lebensqualität durch optimales Therapiemanagement.
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Peters M., Dasilva A., Weckermann Dorothea, Oberneder R., Ebner B., Kirchinger P., Fetter A., Köhne-Volland R., Baeuerle P., Gjorstrup P.. Phase I study of the novel fully human monoclonal antibody MT201, directed against epithelial cellular adhesion molecule (Ep-CAM), in patients with hormone-refractory prostate cancer (HRPC). https://doi.org/10.1200/jco.2004.22.90140.2600
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Weckermann Dorothea. The role of hormonal therapy in the treatment of locally advanced prostate cancer—regional perspectives: Europe. https://doi.org/10.1016/j.eursup.2003.12.003
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2003

Wawroschek Friedhelm, Hamm Michael, Weckermann Dorothea, Vogt Harry, Harzmann Rolf. Lymph node staging in clinically localized prostate cancer. https://doi.org/10.1159/000071833
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Wawroschek Friedhelm, Vogt Harry, Wengenmair Hermann, Weckermann Dorothea, Hamm Michael, Keil Mathias, Graf Gerhard, Heidenreich Peter, Harzmann Rolf. Prostate lymphoscintigraphy and radio-guided surgery for sentinel lymph node identification in prostate cancer. https://doi.org/10.1159/000070140
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Wawroschek F., Dorn R., Hamm M., Fretschner M., Wengenmair H., Harzmann R., Weckermann Dorothea. Sentinel-Lymphknoten-Chirurgie bei urologischen Malignomen. https://doi.org/10.1007/s00761-003-0520-3
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Wawroschek Friedhelm, Wagner Theodor, Hamm Michael, Weckermann Dorothea, Vogt Harry, Märkl Bruno, Gordijn Ronald, Harzmann Rolf. The influence of serial sections, immunohistochemistry, and extension of pelvic lymph node dissection on the lymph node Status in clinically localized prostate cancer. https://doi.org/10.1016/s0302-2838(02)00450-5
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2002

Kufer Peter, Zippelius Alfred, Lutterbüse Ralf, Mecklenburg Ingo, Enzmann Thomas, Montag Anthony, Weckermann Dorothea, Passlick Bernward, Prang Nadja, Reichardt Peter, Dugas Martin, Köllermann Manfred W., Pantel Klaus, Riethmüller Gert. Heterogeneous expression of MAGE-A genes in occult disseminated tumor cells: a novel multimarker reverse transcription-polymerase chain reaction for diagnosis of micrometastatic disease.
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Hamm Michael, Knopfle Egbert, Wartenberg Susanne, Wawroschek Friedhelm, Weckermann Dorothea, Harzmann Rolf. Low dose unenhanced helical computerized tomography for the evaluation of acute flank pain. https://doi.org/10.1016/S0022-5347(05)65178-6
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Wawroschek F., Hamm M., Vogt H., Wagner T., Weckermann Dorothea, Harzmann R.. Sentinel-Lymphadenektomie beim Prostatakarzinom. https://doi.org/10.1007/s00131-002-0241-8
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2001

Weckermann Dorothea, Wawroschek Friedhelm, Hamm Michael, Haude Karlheinz, Harzmann Rolf. Biochemical course after radical retropubic prostatectomy: preliminary results. https://doi.org/10.1159/000052479
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Weckermann Dorothea, Müller Peter, Wawroschek Friedhelm, Harzmann Rolf, Riethmüller Gert, Schlimok Günther. Disseminated cytokeratin positive tumor cells in the bone marrow of patients with prostate cancer: detection and prognostic value. https://doi.org/10.1016/s0022-5347(05)66046-6
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Wawroschek F., Vogt H., Bachter D., Weckermann Dorothea, Hamm M., Wagner T., Harzmann R.. Gamma-Sonden geführte Lymphadenektomie beim Harnröhren- und Peniskarzinom. https://doi.org/10.1055/s-2001-14362
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Hamm M., Häckel T., Wawroschek F., Knöpfle E., Häuser H., Weckermann Dorothea, Harzmann R.. Native Spiral-Computertomographie in der Akutdiagnostik von Flankenschmerzen: Untersuchung bei Kontraindikationen zur Kontrastmittelgabe. https://doi.org/10.1007/s001200170026
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Hamm M., Weckermann Dorothea, Wawroschek F., Harzmann R.. Palliation und Supportivtherapie beim inkurablen Nierenzellkarzinom. https://doi.org/10.1007/s007610170081
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Wawroschek Friedhelm, Vogt Harry, Weckermann Dorothea, Wagner Theodor, Hamm Michael, Harzmann Rolf. Radioisotope guided pelvic lymph node dissection for prostate cancer. https://doi.org/10.1016/S0022-5347(05)65659-5
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Hamm Michael, Wawroschek Friedhelm, Weckermann Dorothea, Knöpfle Egbert, Häckel Thomas, Häuser Hannes, Krawczak Gunnar, Harzmann Rolf. Unenhanced helical computed tomography in the evaluation of acute flank pain. https://doi.org/10.1159/000052486
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2000

Hamm M., Wawroschek F., Weckermann Dorothea, Wagner T., v. Klinggräff G., Harzmann R.. Bedeutung testikulärer Mikroverkalkungen („Sternhimmelhoden”) in der Frühdiagnostik maligner Keimzellneoplasie. https://doi.org/10.1055/s-2000-8244
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Blana A., Wawroschek F., Höpfner W., Weckermann Dorothea. Differentialdiagnose und Therapie intra- und periprostatischer zystischer Raumforderungen: Fallbeispiele und Literaturübersicht. https://doi.org/10.1007/s001310050012
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Wawroschek Friedhelm, Vogt Harry, Bachter Dieter, Weckermann Dorothea, Hamm Michael, Harzmann Rolf. First experience with gamma probe guided sentinel lymph node surgery in penile cancer. https://doi.org/10.1007/s002400000125
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Braun M., Engelmann U., Harzmann R., Höfner K., Jonas U., Madersbacher S., Marberger M., Weckermann Dorothea, Wawroschek F., Zumbé J.. Wärmeanwendung. https://doi.org/10.1007/978-3-642-59580-6_12
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1999

Wawroschek F., Weckermann Dorothea. Aktueller Stand der perioperativen Thromboembolie-prophylaxe in der Urologie. https://doi.org/10.1007/s001310050381
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Weckermann Dorothea, Wawroschek Friedhelm, Krawczak Gunnar, Haude Karl-Heinz, Harzmann Rolf. Does the immunocytochemical detection of epithelial cells in bone marrow (micrometastasis) influence the time to biochemical relapse after radical prostatectomy?. https://doi.org/10.1007/s002400050125
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Weckermann Dorothea, Maassen C., Wawroschek Friedhelm, Harzmann R.. Improved discrimination of prostate cancer and benign prostatic hyperplasia by means of the quotient of free and total PSA. https://doi.org/10.1023/A:1007178203861
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Weckermann Dorothea, Wawroschek Friedhelm, Schipp J., Krawczak G., Harzmann R.. Metabolic changes and urodynamic findings after continent urinary diversion. https://doi.org/10.1023/A:1007164722942
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Weckermann Dorothea, Müller Peter, Wawroschek Friedhelm, Krawczak Gunnar, Riethmüller Gert, Schlimok Günter. Micrometastases of bone marrow in localized prostate cancer: correlation with established risk factors. https://doi.org/10.1200/jco.1999.17.11.3438
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Weckermann Dorothea, Wawroschek F., Harzmann R.. Pathophysiologie des Schmerzes: Grundlagen der Tumorschmerztherapie. https://doi.org/10.1007/s001310050280
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Wawroschek F., Weckermann Dorothea, Harzmann R.. Praxisrelevante Hinweise zur Arzneimitteltherapie tumorbedingter Schmerzen. https://doi.org/10.1007/s001310050279
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Wawroschek Friedhelm, Vogt Harry, Weckermann Dorothea, Wagner Theodor, Harzmann Rolf. The sentinel lymph node concept in prostate cancer – first results of gamma probe-guided sentinel lymph node identification. https://doi.org/10.1159/000020054
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Weckermann Dorothea, Harzmann R., Haude KH., Wawroschek Friedhelm. Wertigkeit von Cytokeratin 18-positiven Zellen im Knochenmark beim lokalisierten Prostatakarzinom.
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Wawroschek F., Vogt H., Weckermann Dorothea, Wagner Th., Harzmann R.. Wie sicher ist die modifizierte pelvine Lymphadenektomie beim Prostatakarzinom? Ergebnisse eines neuen Staging-Verfahrens. https://doi.org/10.1055/s-1999-13323
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1998

Weckermann Dorothea, Wawroschek Friedhelm, Harzmann R.. Grundlagen der Tumorschmerztherapie. https://doi.org/10.1007/s001200050230
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Harzmann R., Weckermann Dorothea. Pain therapy and quality of life. https://doi.org/10.1007/s001200050168
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Wawroschek Friedhelm, Weckermann Dorothea, Harzmann R.. Pharmakologische Aspekte bei der Therapie tumorbedingter Schmerzen. https://doi.org/10.1007/s001310050250
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1996

Müller Peter, Weckermann Dorothea, Riethmüller Gert, Schlimok Günter. Detection of genetic alterations in micrometastatic cells in bone marrow of cancer patients by fluorescence in situ hybridization. https://doi.org/10.1016/0165-4608(95)00189-1
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1995

Pantel K., Dickmanns A., Zippelius A., Klein C., Shi J., Hoechtlen-Vollmar W., Schlimok G., Weckermann Dorothea, Oberneder R., Fanning E., Riethmuller G.. Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines. https://doi.org/10.1093/jnci/87.15.1162
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Rotter Ch., Weckermann Dorothea, Harzmann R.. Leiomyom der Harnblase: Differentialdiagnostik und Therapie. https://doi.org/10.1055/s-2008-1057787
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Harzmann R., Weckermann Dorothea. Tumor induction in intestinal urinary reservoirs.
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1994

Pantel Klaus, Schlimok Günther, Angstwurm Matthias, Weckermann Dorothea, Schmaus Werner, Gath Hans, Passlick Bernward, Iizbicki Jacob R., Riethmüller Gert. Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. https://doi.org/10.1089/scd.1.1994.3.165
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Zügel N., Leipprand E., Weckermann Dorothea, Witte Jil. Solitary metastasis to the head of the pancreas in hypernephroid carcinoma.
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Weckermann Dorothea, Azar R., Harzmann R.. TUR-P in lokaler Ischämie: Nutzen und Risiken. https://doi.org/10.1055/s-2008-1058242
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Rotter Ch., Weckermann Dorothea, Harzmann R.. Welche Therapie bei Lipomatosis pelvis?. https://doi.org/10.1055/s-2008-1058201
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1993

Harzmann Rolf, Weckermann Dorothea. Benign prostatic hyperplasia: newer approaches. https://doi.org/10.1097/00042307-199302010-00003
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1992

Harzmann R., Weckermann Dorothea. Evaluation of new technical alternative procedures for therapy of symptomatic benign prostatic hyperplasia.
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Weckermann Dorothea, Schlotmann R., Tietze W., Häckei Th.. Gas formation after renal artery embolisation: genesis and clinical relevance. https://doi.org/10.1159/000282428
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Harzmann R., Weckermann Dorothea. Hyperthermia or thermotherapy of benign prostatic hyperplasia: what is the difference?. https://doi.org/10.1007/978-3-642-77480-5_13
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Harzmann R., Weckermann Dorothea. Problem of secondary malignancy after urinary diversion and enterocystoplasty.
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1991

Harzmann R., Weckermann Dorothea. Lokale Hyperthermie bei Prostataerkrankungen?. https://doi.org/10.1055/s-2008-1060468
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1990

Harzmann R., Weckermann Dorothea, Hirnle P., Haefelinger G., Schweinsberg F.. Chromolymphography as a means for selective lymphadenectomy. https://doi.org/10.1055/s-2008-1060668
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Harzmann R., Weckermann Dorothea. Importance of doppler sonography in urology (with 1 color plate). https://doi.org/10.1159/000281718
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1989

Weckermann Dorothea, Harzmann R.. Grenzen der perkutanen Steintherapie im Kindesalter. https://doi.org/10.1007/978-3-642-83800-2_243
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Weckermann Dorothea, Weckermann J., Wagner Th., Karsten A.. Vesikointestinale Fistel beim malignen Lymphom. https://doi.org/10.1055/s-2008-1061184
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1988

Harzmann R., Weckermann Dorothea. Perkutane transrenale Harnleiterokklusion mit Hilfe eines neuen Verfahrens. https://doi.org/10.1055/s-2008-1061393
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Harzmann R., Weckermann Dorothea. Stage-adapted pain therapy in advanced malignant urologic diseases.
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Rüster S., Karsten A., Weckermann Dorothea, Harzmann R.. Therapeutische Aspekte des beiderseitigen Seminoms. https://doi.org/10.1007/978-3-642-73492-2_50
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Weckermann Dorothea, Karsten A., Harzmann R.. Urodynamic findings in vegetative urogenital syndrome.
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1987

Weckermann Dorothea, Harzmann R.. Uroarterieller Shunt nach Transureterouretero-Cutaneostomie. https://doi.org/10.1055/s-2008-1061416
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Harzmann R., Weckermann Dorothea, Fleischmann R.. Östrogeninduzierte intrahepatische Cholestase beim Prostatakarzinom. https://doi.org/10.1007/978-3-642-83170-6_200
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1986

Schrecker O., Weckermann Dorothea, Weckermann J., Jellinek H.. Lipoprotein changes induced by intravenously administered lipid emulsion leading to arteriosclerotic lesions in the rat.
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