• molecular mechanisms of epigenetic programming
• epigenetic control of differentiation in health and disease
• statistical testing and modeling for multi-omics data
• performant NGS data processing

Melinda Czeh, Sina Stäble, Stephen Krämer, Lena Tepe, Sweta Talyan, Joana Carrelha, Yiran Meng, Barbara Heitplatz, Marius Schwabenland, Michael D. Milsom, Christoph Plass, Marco Prinz, Matthias Schlesner, Miguel A. Andrade-Navarro, Claus Nerlov, Sten Eiric W. Jacobsen, Daniel B. Lipka and Frank Rosenbauer. 2022. DNMT1 deficiency impacts on plasmacytoid dendritic cells in homeostasis and autoimmune Disease. The Journal of Immunology 208, 2, 358–370.

DOI: 10.4049/jimmunol.2100624

Marina Scheller, Anne Kathrin Ludwig, Stefanie Göllner, Christian Rohde, Stephen Krämer, Sina Stäble, Maike Janssen, James-Arne Müller, Lixiazi He, Nicole Bäumer, Christian Arnold, Joachim Gerß, Maximilian Schönung, Christian Thiede, Christian Niederwieser, Dietger Niederwieser, Hubert Serve, Wolfgang E. Berdel, Ulrich Thiem, Inga Hemmerling, Florian Leuschner, Christoph Plass, Matthias Schlesner, Judith Zaugg, Michael D. Milsom, Andreas Trumpp, Caroline Pabst, Daniel B. Lipka and Carsten Müller-Tidow. 2021. Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response. Nature Cancer 2, 5, 527–544. DOI: 10.1038/s43018-021-00213-9

Ani Grigoryan, Johannes Pospiech, Stephen Krämer, Daniel Lipka, Thomas Liehr, Hartmut Geiger, Hiroshi Kimura, Medhanie A. Mulaw and  Maria C. Florian. 2021. Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells. Stem Cell Reports 16, 4, 708–716.

Daniel Hübschmann, Lea Jopp‐Saile, Carolin Andresen, Stephen Krämer, Zuguang Gu, Christoph E. Heilig, Simon Kreutzfeldt, Veronica Teleanu, Stefan Fröhling, Roland Eils and Matthias Schlesner. 2020. Analysis of mutational signatures with yet another package for signature analysis. Genes, Chromosomes and Cancer 60, 5, 314–331. DOI: 10.1002/gcc.22918