PD. Dr. Kristin Pogoda

Arbeitsgruppenleiterin „Zell-Zell-Kommunikation“ (im Aufbau)
Physiologie
Telefon: +49 821 598 - 3152
E-Mail: kristin.pogoda@med.uni-augsburg.de
Raum: 10F 1006 (SHS)
Adresse: Werner-von-Siemens-Straße 6 (Sigma Technopark), 86159 Augsburg

Forschungsschwerpunkte

Role of connexins during vascular remodeling processes
Mutations within the PKA phosphorylation site of Cx43 additionally increase the migration enhancing effect of Cx43. Modified from: Kameritsch P, Kiemer F, Beck H, Mannell H, Pohl U and Pogoda K. PKA negatively modulates the migration enhancing effect of © Universität Augsburg
Regulation of myoendothelial gap junctions in the vascular system
Composition and regulation of myoendothelial gap junctions. Pogoda K and Kameritsch P. Molecular regulation of myoendothelial gap junctions. Curr Opin Pharmacol. 2019 Apr 15;45:16-22. © Universität Augsburg
Functional impact of small connexin isoforms
Channel-independent and channel-dependent functions of connexins are regulated via posttranslational modifications (PTM) and/or protein-protein interactions at the cytoplasmic carboxyl tail. © Universität Augsburg

 

 

 

Functional impact and regulation of connexins and gap junctions in the vascular system

Role of connexins during vascular remodeling processes

Role of connexins during vascular remodeling processes

Functional impact of small connexin isoforms

Functional impact of small connexin isoforms

Regulation of myoendothelial gap junctions in the vascular system

Regulation of myoendothelial gap junctions in the vascular system

 

 

Publikationen

Kristin Pogoda
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2006 | 2004 | 2003 | 2002 | 2001

2022

Müller Martin Bernhard, Hübner Max, Li Lei, Tomasi Stephanie, Ließke Valena, Effinger David, Hirschberger Simon, Pogoda Kristin, Sperandio Markus, Kreth Simone. Cell-crossing functional network driven by microRNA-125a regulates endothelial permeability and monocyte trafficking in acute inflammation. https://doi.org/10.3389/fimmu.2022.826047
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Mannell Hanna, Kameritsch Petra, Beck Heike, Pfeifer Alexander, Pohl Ulrich, Pogoda Kristin. Cx43 promotes endothelial cell migration and angiogenesis via the tyrosine phosphatase SHP-2. https://doi.org/10.3390/ijms23010294
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2021

Kameritsch Petra, Singer Miriam, Nuernbergk Christoph, Rios Natalia, Reyes Aníbal M., Schmidt Kjestine, Kirsch Julian, Schneider Holger, Müller Susanna, Pogoda Kristin, Cui Ruicen, Kirchner Thomas, de Wit Cor, Lange-Sperandio Bärbel, Pohl Ulrich, Conrad Marcus, Radi Rafael, Beck Heike. The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity. https://doi.org/10.1073/pnas.1921828118
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2020

Rivière Thibaud, Bader Almke, Pogoda Kristin, Walzog Barbara, Maier-Begandt Daniela. Structure and emerging functions of LRCH proteins in leukocyte biology. https://doi.org/10.3389/fcell.2020.584134
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Hübner Max, Effinger David, Wu Tingting, Strauß Gabriele, Pogoda Kristin, Kreth Friedrich-Wilhelm, Kreth Simone. The IL-1 antagonist anakinra attenuates glioblastoma aggressiveness by dampening tumor-associated inflammation. https://doi.org/10.3390/cancers12020433
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Kameritsch Petra, Pogoda Kristin. The role of connexin 43 and pannexin 1 during acute inflammation. https://doi.org/10.3389/fphys.2020.594097
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2019

Aasen Trond, Leithe Edward, Graham Sheila V., Kameritsch Petra, Mayán María D., Mesnil Marc, Pogoda Kristin, Tabernero Arantxa. Connexins in cancer: bridging the gap to the clinic. https://doi.org/10.1038/s41388-019-0741-6
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Pogoda Kristin, Kameritsch P., Mannell H., Pohl U.. Connexins in the control of vasomotor function. https://doi.org/10.1111/apha.13108
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Heun Yvonn, Pircher Joachim, Czermak Thomas, Bluem Philipp, Hupel Georg, Bohmer Monica, Kraemer Bjoern F., Pogoda Kristin, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Hübner Max, Kreth Simone, Claus Ralf A., Weis Sebastian, Ungelenk Luisa, Krötz Florian, Pohl Ulrich, Mannell Hanna. Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in sepsis. https://doi.org/10.1016/j.ebiom.2019.03.034
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Pogoda Kristin, Kameritsch Petra. Molecular regulation of myoendothelial gap junctions. https://doi.org/10.1016/j.coph.2019.03.006
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Kameritsch Petra, Kiemer Felizitas, Mannell Hanna, Beck Heike, Pohl Ulrich, Pogoda Kristin. PKA negatively modulates the migration enhancing effect of Connexin 43. https://doi.org/10.1016/j.bbamcr.2019.02.001
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Heun Yvonn, Grundler Groterhorst Katharina, Pogoda Kristin, Kraemer Bjoern F., Pfeifer Alexander, Pohl Ulrich, Mannell Hanna. The phosphatase SHP-2 activates HIF-1α in wounds in vivo by inhibition of 26S proteasome activity. https://doi.org/10.3390/ijms20184404
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2018

Mesnil Marc, Aasen Trond, Boucher Jonathan, Chépied Amandine, Cronier Laurent, Defamie Norah, Kameritsch Petra, Laird Dale W., Lampe Paul D., Lathia Justin D., Leithe Edward, Mehta Parmender P., Monvoisin Arnaud, Pogoda Kristin, Sin Wun-Chey, Tabernero Arantxa, Yamasaki Hiroshi, Yeh Elizabeth S., Dagli Maria Lucia Zaidan, Naus Christian C.. An update on minding the gap in cancer. https://doi.org/10.1016/j.bbamem.2017.06.015
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2017

Heun Yvonn, Pogoda Kristin, Anton Martina, Pircher Joachim, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Kameritsch Petra, Mykhaylyk Olga, Plank Christian, Kroetz Florian, Pohl Ulrich, Mannell Hanna. HIF-1α dependent wound healing angiogenesis in vivo can be controlled by site-specific lentiviral magnetic targeting of SHP-2. https://doi.org/10.1016/j.ymthe.2017.04.007
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Pogoda Kristin, Mannell Hanna, Blodow Stephanie, Schneider Holger, Schubert Kai Michael, Qiu Jiehua, Schmidt Andreas, Imhof Axel, Beck Heike, Tanase Laurentia Irina, Pfeifer Alexander, Pohl Ulrich, Kameritsch Petra. NO augments endothelial reactivity by reducing myoendothelial calcium signal spreading: a novel role for Cx37 (Connexin 37) and the protein tyrosine phosphatase SHP-2. https://doi.org/10.1161/atvbaha.117.309913
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2016

Kirsch Julian, Schneider Holger, Pagel Judith-Irina, Rehberg Markus, Singer Miriam, Hellfritsch Juliane, Chillo Omary, Schubert Kai Michael, Qiu Jiehua, Pogoda Kristin, Kameritsch Petra, Uhl Bernd, Pircher Joachim, Deindl Elisabeth, Müller Susanna, Kirchner Thomas, Pohl Ulrich, Conrad Marcus, Beck Heike. Endothelial dysfunction, and a prothrombotic, proinflammatory phenotype is caused by loss of mitochondrial thioredoxin reductase in endothelium. https://doi.org/10.1161/atvbaha.116.307843
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Pogoda Kristin, Kameritsch Petra, Retamal Mauricio A., Vega José L.. Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision. https://doi.org/10.1186/s12860-016-0099-3
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2015

Kameritsch Petra, Kiemer Felizitas, Beck Heike, Pohl Ulrich, Pogoda Kristin. Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1. https://doi.org/10.1016/j.bbamcr.2015.08.004
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Hellfritsch Juliane, Kirsch Julian, Schneider Manuela, Fluege Tamara, Wortmann Markus, Frijhoff Jeroen, Dagnell Markus, Fey Theres, Esposito Irene, Kölle Pirkko, Pogoda Kristin, Angeli José Pedro Friedmann, Ingold Irina, Kuhlencordt Peter, Östman Arne, Pohl Ulrich, Conrad Marcus, Beck Heike. Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis. https://doi.org/10.1089/ars.2014.5889
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2014

Pogoda Kristin, Füller Monika, Pohl Ulrich, Kameritsch Petra. NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions. https://doi.org/10.1186/1478-811x-12-33
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2013

Kameritsch P., Khandoga N., Pohl U., Pogoda Kristin. Gap junctional communication promotes apoptosis in a connexin-type-dependent manner. https://doi.org/10.1038/cddis.2013.105
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2012

Kameritsch Petra, Pogoda Kristin, Pohl Ulrich. Channel-independent influence of connexin 43 on cell migration. https://doi.org/10.1016/j.bbamem.2011.11.016
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Kameritsch Petra, Pogoda Kristin, Ritter Angela, Münzing Silvia, Pohl Ulrich. Gap junctional communication controls the overall endothelial calcium response to vasoactive agonists. https://doi.org/10.1093/cvr/cvr345
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2010

Behrens Juliane, Kameritsch Petra, Wallner Stefan, Pohl Ulrich, Pogoda Kristin. The carboxyl tail of Cx43 augments p38 mediated cell migration in a gap junction-independent manner. https://doi.org/10.1016/j.ejcb.2010.06.003
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2006

Pammer Johannes, Reinisch Christine, Birner Peter, Pogoda Kristin, Sturzl Michael, Tschachler Erwin. Interferon-α prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation. https://doi.org/10.1038/labinvest.3700461
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2004

Naschberger Elisabeth, Werner Thomas, Vicente Ana B., Guenzi Eric, Töpolt Kristin, Leubert René, Lubeseder-Martellato Clara, Nelson Peter J., Stürzl Michael. Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. https://doi.org/10.1042/bj20031873
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2003

Guenzi Eric, Töpolt Kristin, Lubeseder‐Martellato Clara, Jörg Anita, Naschberger Elisabeth, Benelli Roberto, Albini Adriana, Stürzl Michael. The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. https://doi.org/10.1093/emboj/cdg382
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2002

Lubeseder-Martellato Clara, Guenzi Eric, Jörg Anita, Töpolt Kristin, Naschberger Elisabeth, Kremmer Elisabeth, Zietz Christian, Tschachler Erwin, Hutzler Peter, Schwemmle Martin, Matzen Kathrin, Grimm Thomas, Ensoli Barbara, Stürzl Michael. Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. https://doi.org/10.1016/s0002-9440(10)64452-5
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2001

Guenzi E., Töpolt Kristin, Cornali Emmanuelle, Lubeseder‐Martellato Clara, Jörg Anita, Matzen Kathrin, Zietz Christian, Kremmer Elisabeth, Nappi Filomena, Schwemmle Martin, Hohenadl Christine, Barillari Giovanni, Tschachler Erwin, Monini Paolo, Ensoli Barbara, Stürzl Michael. The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. https://doi.org/10.1093/emboj/20.20.5568
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Lebenslauf

 

Vita

 

 

1990-1995                           study of food science/biotechnology, Humboldt-University Berlin 

1995-1997                           post-graduate studies in economic sciences, Technical University Dresden

1996-1997                           erasmus scholarship, University of Rome, Italy

1998-1999                           technical assistant, Gene Center Munich, LMU Munich

2000-2004                           PhD thesis, Helmholtz Research Center Munich, Dr. rer. nat.

2004-2020                           group leader, scientific assistant, Institute of Cardiovascular Physiology and Pathophysiology, LMU, Munich

2016                                    Habilitation in Physiology, LMU Munich

03/2020 – present               scientific assistant, Institute for Theoretical Medicine, Physiology, University of Augsburg

 

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