Publikationen

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2024

Dragano Nathalia R. V., Milbank Edward, Haddad-Tóvolli Roberta, Garrido-Gil Pablo, Nóvoa Eva, Fondevilla Marcos F., Capelli Valentina, Zanesco Ariane Maria, Solon Carina, Morari Joseane, Pires Leticia, Estevez-Salguero Ánxela, Beiroa Daniel, González-García Ismael, Barca-Mayo Olga, Diéguez Carlos, Nogueiras Ruben, Labandeira-García José L., Rexen Ulven Elisabeth, Ulven Trond, Claret Marc, Velloso Licio A., López Miguel. Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance. https://doi.org/10.1016/j.molmet.2023.101840
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Maccioni Riccardo, Travisan Caterina, Badman Jack, Zerial Stefania, Wagener Annika, Andrade-Talavera Yuniesky, Picciau Federico, Grassi Caterina, Chen Gefei, Lemoine Laetitia, Fisahn André, Jiang Richeng, Fluhrer Regina, Mentrup Torben, Schröder Bernd, Nilsson Per, Tambaro Simone. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. https://doi.org/10.1016/j.pneurobio.2024.102585
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Mentrup Torben, Leinung Nadja, Patel Mehul, Fluhrer Regina, Schröder Bernd. The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis. https://doi.org/10.1111/febs.16941
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2023

Glunk Viktoria, Laber Samantha, Sinnott-Armstrong Nasa, Sobreira Debora R., Strobel Sophie M., Batista Thiago M., Kubitz Phil, Moud Bahareh Nemati, Ebert Hannah, Huang Yi, Brandl Beate, Garbo Garrett, Honecker Julius, Stirling David R., Abdennur Nezar, Calabuig-Navarro Virtu, Skurk Thomas, Ocvirk Soeren, Stemmer Kerstin, Cimini Beth A., Carpenter Anne E., Dankel Simon N., Lindgren Cecilia M., Hauner Hans, Nobrega Marcelo A., Claussnitzer Melina. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. https://doi.org/10.1038/s42255-023-00807-w
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Kulaj Konxhe, Harger Alexandra, Bauer Michaela, Caliskan Özüm S., Gupta Tilak Kumar, Chiang Dapi Menglin, Milbank Edward, Reber Josefine, Karlas Angelos, Kotzbeck Petra, Sailer David N., Volta Francesco, Lutter Dominik, Prakash Sneha, Merl-Pham Juliane, Ntziachristos Vasilis, Hauner Hans, Pfaffl Michael W., Tschöp Matthias H., Müller Timo D., Hauck Stefanie M., Engel Benjamin D., Gerdes Jantje M., Pfluger Paul T., Krahmer Natalie, Stemmer Kerstin. Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo. https://doi.org/10.1038/s41467-023-36148-1
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Sulewska Małgorzata, Berger Monika, Damerow Manuela, Schwarzer David, Büttner Falk F. R., Bethe Andrea, Taft Manuel H., Bakker Hans, Mühlenhoff Martina, Gerardy-Schahn Rita, Priem Bernard, Fiebig Timm. Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection. https://doi.org/10.1016/j.carbpol.2023.121182
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Stemmer Kerstin, Müller Timo D.. GLP-1-Mimetika — wegweisend zur Behandlung von Diabetes und Adipositas. https://doi.org/10.1007/s12268-023-1919-6
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Smit P., Buehring-Uhle C., Nather C., Negraschus A., Goldmann U., Papadopoulou Alkmini A., Riviere J., Morath V., Henkel E., Bromberger T., Goetze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. Inhibiting MGAT1-mediated N-glycosylation reduces proliferation and adhesion of AML cells and increases affinities of anti-SLC3A2 directed immunotherapies [Abstract]. https://doi.org/10.1159/000533576
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Krause Christin, Britsemmer Jan H., Bernecker Miriam, Molenaar Anna, Taege Natalie, Geißler Cathleen, Kaehler Meike, Iben Katharina, Judycka Anna, Wagner Jonas, Wolter Stefan, Mann Oliver, Pfluger Paul T., Cascorbi Ingolf, Lehnert Hendrik, Stemmer Kerstin, Schriever Sonja C., Kirchner Henriette. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity. https://doi.org/10.1101/2023.10.02.560594
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Kespohl Birte, Hegele Anna‐Lena, Düsterhöft Stefan, Bakker Hans, Büttner Falk F. R., Hartig Roland, Lokau Juliane, Garbers Christoph. Molecular characterization of the craniosynostosis‐associated interleukin‐11 receptor variants p.T306_S308dup and p.E364_V368del. https://doi.org/10.1111/febs.17015
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Moreira Inês B., Rossdam Charlotte, Beimdiek Julia, Vicente Manuel M., Schmitz Jessica, Oberbeck Astrid, Bräsen Jan H., Tezval Hossein, Büttner Falk F. R.. Neolactotetraosylceramide: a novel non-invasive urinary biomarker for bladder cancer. https://doi.org/10.1101/2023.08.08.552442
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Burock Robert, Cajic Samanta, Hennig René, Büttner Falk F. R., Reichl Udo, Rapp Erdmann. Reliable N-glycan analysis–removal of frequently occurring oligosaccharide impurities by enzymatic degradation. https://doi.org/10.3390/molecules28041843
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Hoeppner Sabine, Schröder Bernd, Fluhrer Regina. Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling. https://doi.org/10.1111/febs.16968
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Rossdam Charlotte, Brand Smilla, Beimdiek Julia, Oberbeck Astrid, Albers Marco Darius, Naujok Ortwin, Büttner Falk F. R.. Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells. https://doi.org/10.1101/2023.08.30.555456
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Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Sörensen-Zender Inga, Fenske Arno, Weinhold Birgit, Schmitt Roland, Tiede Andreas, Büttner Falk F. R., Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects against complement attack. https://doi.org/10.1038/s41420-023-01686-6
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2022

Hütte Hermann J., Tiemann Birgit, Shcherbakova Aleksandra, Grote Valerian, Hoffmann Marcus, Povolo Lorenzo, Lommel Mark, Strahl Sabine, Vakhrushev Sergey Y., Rapp Erdmann, Büttner Falk F. R., Halim Adnan, Imberty Anne, Bakker Hans. A bacterial mannose binding lectin as a tool for the enrichment of C- and O-mannosylated peptides. https://doi.org/10.1021/acs.analchem.2c00742
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Abuhattum Shada, Kotzbeck Petra, Schlüßler Raimund, Harger Alexandra, Ariza de Schellenberger Angela, Kim Kyoohyun, Escolano Joan-Carles, Müller Torsten, Braun Jürgen, Wabitsch Martin, Tschöp Matthias, Sack Ingolf, Brankatschk Marko, Guck Jochen, Stemmer Kerstin, Taubenberger Anna V.. Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens. https://doi.org/10.1038/s41598-022-13324-9
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Heard Amanda, Landmann Jack H., Hansen Ava R., Papadopolou Alkmini, Hsu Yu-Sung, Selli Mehmet Emrah, Warrington John M., Lattin John, Chang Jufang, Ha Helen, Haug-Kröper Martina, Doray Balraj, Gill Saar, Ruella Marco, Hayer Katharina E., Weitzman Matthew D., Green Abby M., Fluhrer Regina, Singh Nathan. Antigen glycosylation regulates efficacy of CAR T cells targeting CD19. https://doi.org/10.1038/s41467-022-31035-7
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Seegers Carla I. I., Ramón Roth Isabel, Zarnovican Patricia, Büttner Falk F. R., Routier Françoise H.. Characterization of a gene cluster involved in Aspergillus fumigatus zwitterionic glycosphingolipid synthesis. https://doi.org/10.1093/glycob/cwac036
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Quarta Carmelo, Stemmer Kerstin, Novikoff Aaron, Yang Bin, Klingelhuber Felix, Harger Alex, Bakhti Mostafa, Bastidas-Ponce Aimee, Baugé Eric, Campbell Jonathan E., Capozzi Megan, Clemmensen Christoffer, Collden Gustav, Cota Perla, Douros Jon, Drucker Daniel J., DuBois Barent, Feuchtinger Annette, Garcia-Caceres Cristina, Grandl Gerald, Hennuyer Nathalie, Herzig Stephan, Hofmann Susanna M., Knerr Patrick J., Kulaj Konxhe, Lalloyer Fanny, Lickert Heiko, Liskiewicz Arek, Liskiewicz Daniela, Maity Gandhari, Perez-Tilve Diego, Prakash Sneha, Sanchez-Garrido Miguel A., Zhang Qian, Staels Bart, Krahmer Natalie, DiMarchi Richard D., Tschöp Matthias H., Finan Brian, Müller Timo D.. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. https://doi.org/10.1038/s42255-022-00617-6
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Pradhan Pooja, Vijayan Vijith, Cirksena Karsten, Büttner Falk F. R., Igarashi Kazuhiko, Motterlini Roberto, Foresti Roberta, Immenschuh Stephan. Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. https://doi.org/10.1016/j.redox.2022.102265
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Cumin Cécile, Huang Yen-Lin, Rossdam Charlotte, Ruoff Felix, Céspedes Susana Posada, Liang Ching-Yeu, Lombardo Flavio C., Coelho Ricardo, Rimmer Natalie, Konantz Martina, López Mónica Núñez, Alam Shahidul, Schmidt Alexander, Calabrese Diego, Fedier Andre, Vlajnic Tatjana, von Itzstein Mark, Templin Markus, Büttner Falk F. R., Everest-Dass Arun, Heinzelmann-Schwarz Viola, Jacob Francis. Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. https://doi.org/10.1016/j.celrep.2022.111181
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Evers Simon S., Shao Yikai, Ramakrishnan Sadeesh K., Shin Jae Hoon, Bozadjieva-Kramer Nadejda, Irmler Martin, Stemmer Kerstin, Sandoval Darleen A., Shah Yatrik M., Seeley Randy J.. Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion. https://doi.org/10.1016/j.celrep.2021.110270
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Papadopoulou Alkmini A., Stelzer Walter, Silber Mara, Schlosser Christine, Spitz Charlotte, Haug-Kröper Martina, Straub Tobias, Müller Stephan A., Lichtenthaler Stefan F., Muhle-Goll Claudia, Langosch Dieter, Fluhrer Regina. Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage. https://doi.org/10.1038/s41598-022-24772-8
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Janciauskiene Sabina, Tumpara Srinu, Schebb Nils Helge, Büttner Falk F. R., Mainka Malwina, Sivaraman Kokilavani, Immenschuh Stephan, Grau Veronika, Welte Tobias, Olejnicka Beata. Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs. https://doi.org/10.3389/fphar.2022.995869
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Mentrup Torben, Stumpff-Niggemann Anna Yamina, Leinung Nadja, Schlosser Christine, Schubert Katja, Wehner Rebekka, Tunger Antje, Schatz Valentin, Neubert Patrick, Gradtke Ann-Christine, Wolf Janina, Rose-John Stefan, Saftig Paul, Dalpke Alexander, Jantsch Jonathan, Schmitz Marc, Fluhrer Regina, Jacobsen Ilse D., Schröder Bernd. Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. https://doi.org/10.1038/s41467-022-29474-3
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Beimdiek Julia, Janciauskiene Sabina, Wrenger Sabine, Volland Sonja, Rozy Adriana, Fuge Jan, Olejnicka Beata, Pink Isabell, Illig Thomas, Popov Alexander, Chorostowska Joanna, Büttner Falk F. R., Welte Tobias. Plasma markers of COVID-19 severity: a pilot study. https://doi.org/10.1186/s12931-022-02272-7
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Bühring-Uhle C., Smit P., Negraschus A., Morath V., Goldmann U., Papadopoulou Alkmini A., Heider M., Riviere J., Götze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. SPPL3 and its substrate glycosyltransferases regulate the N-glycosylation of SLC3A2 and alter the affinities of anti-SLC3A2 immunotherapies in AML [Abstract]. https://doi.org/10.1159/000526456
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Beimdiek Julia, Hennig René, Burock Robert, Puk Oliver, Biskup Saskia, Rapp Erdmann, Lesinski-Schiedat Anke, Büttner Falk F. R., Das Anibh M.. Serum N-glycomics of a novel CDG-IIb patient reveals aberrant IgG glycosylation. https://doi.org/10.1093/glycob/cwac003
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Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Tiede Andreas, Büttner Falk F. R., Weinhold Birgit, Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects trophoblasts, erythrocytes and endothelial cells against complement attack. https://doi.org/10.1101/2022.01.24.477475
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2021

Aliluev Alexandra, Tritschler Sophie, Sterr Michael, Oppenländer Lena, Hinterdobler Julia, Greisle Tobias, Irmler Martin, Beckers Johannes, Sun Na, Walch Axel, Stemmer Kerstin, Kindt Alida, Krumsiek Jan, Tschöp Matthias H., Luecken Malte D., Theis Fabian J., Lickert Heiko, Böttcher Anika. Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice. https://doi.org/10.1038/s42255-021-00458-9
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Janosz Ewa, Hetzel Miriam, Spielmann Hanna, Tumpara Srinu, Rossdam Charlotte, Schwabbauer Marc, Kloos Doreen, von Kaisenberg Constantin, Schambach Axel, Büttner Falk F. R., Janciauskiene Sabina, Lachmann Nico, Moritz Thomas. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. https://doi.org/10.1038/s41434-021-00269-3
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Taubert Richard, Engel Bastian, Diestelhorst Jana, Hupa‐Breier Katharina L., Behrendt Patrick, Baerlecken Niklas T., Sühs Kurt‐Wolfram, Janik Maciej K., Zachou Kalliopi, Sebode Marcial, Schramm Christoph, Londoño María‐Carlota, Habes Sarah, Oo Ye H., Lalanne Claudine, Pape Simon, Schubert Maren, Hust Michael, Dübel Stefan, Thevis Mario, Jonigk Danny, Beimdiek Julia, Büttner Falk F. R., Drenth Joost P. H., Muratori Luigi, Adams David H., Dyson Jessica K., Renand Amédée, Graupera Isabel, Lohse Ansgar W., Dalekos George N., Milkiewicz Piotr, Stangel Martin, Maasoumy Benjamin, Witte Torsten, Wedemeyer Heiner, Manns Michael P., Jaeckel Elmar. Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis. https://doi.org/10.1002/hep.32134
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Novikoff Aaron, O'Brien Shannon L., Bernecker Miriam, Grandl Gerald, Kleinert Maximilian, Knerr Patrick J., Stemmer Kerstin, Klingenspor Martin, Zeigerer Anja, DiMarchi Richard, Tschöp Matthias H., Finan Brian, Calebiro Davide, Müller Timo D.. Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists. https://doi.org/10.1016/j.molmet.2021.101181
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Cirksena Karsten, Hütte Hermann J., Shcherbakova Aleksandra, Thumberger Thomas, Sakson Roman, Weiss Stefan, Jensen Lars Riff, Friedrich Alina, Todt Daniel, Kuss Andreas W., Ruppert Thomas, Wittbrodt Joachim, Bakker Hans, Büttner Falk F. R.. The C-mannosylome of human induced pluripotent stem cells implies a role for ADAMTS16 C-mannosylation in eye development. https://doi.org/10.1016/j.mcpro.2021.100092
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Zhang Qian, Delessa Challa Tenagne, Augustin Robert, Bakhti Mostafa, Colldén Gustav, Drucker Daniel J., Feuchtinger Annette, Caceres Cristina Garcia, Grandl Gerald, Harger Alexandra, Herzig Stephan, Hofmann Susanna, Holleman Cassie Lynn, Jastroch Martin, Keipert Susanne, Kleinert Maximilian, Knerr Patrick J., Kulaj Konxhe, Legutko Beata, Lickert Heiko, Liu Xue, Luippold Gerd, Lutter Dominik, Malogajski Emilija, Medina Marta Tarquis, Mowery Stephanie A., Blutke Andreas, Perez-Tilve Diego, Salinno Ciro, Sehrer Laura, DiMarchi Richard D., Tschöp Matthias H., Stemmer Kerstin, Finan Brian, Wolfrum Christian, Müller Timo D.. The Glucose-dependent Insulinotropic Polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. https://doi.org/10.1016/j.cmet.2021.01.015
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Oppenländer Lena, Palit Subarna, Stemmer Kerstin, Greisle Tobias, Sterr Michael, Salinno Ciro, Bastidas-Ponce Aimée, Feuchtinger Annette, Böttcher Anika, Ansarullah , Theis Fabian J., Lickert Heiko. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. https://doi.org/10.1016/j.molmet.2021.101330
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2020

Jirmo Adan C., Rossdam Charlotte, Grychtol Ruth, Happle Christine, Gerardy‐Schahn Rita, Büttner Falk F. R., Hansen Gesine. Differential expression patterns of glycosphingolipids and C‐type lectin receptors on immune cells in absence of functional regulatory T cells. https://doi.org/10.1002/iid3.334
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Dettmer Rabea, Cirksena Karsten, Münchhoff Julia, Kresse Jasmin, Diekmann Ulf, Niwolik Isabell, Büttner Falk F. R., Naujok Ortwin. FGF2 inhibits early pancreatic lineage specification during differentiation of human embryonic stem cells. https://doi.org/10.3390/cells9091927
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Stemmer Kerstin, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Müller Timo D.. Insights into incretin-based therapies for treatment of diabetic dyslipidemia. https://doi.org/10.1016/j.addr.2020.05.008
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Spitz Charlotte, Schlosser Christine, Guschtschin-Schmidt Nadja, Stelzer Walter, Menig Simon, Götz Alexander, Haug-Kröper Martina, Scharnagl Christina, Langosch Dieter, Muhle-Goll Claudia, Fluhrer Regina. Non-canonical shedding of TNFα by SPPL2a is determined by the conformational flexibility of its transmembrane helix. https://doi.org/10.1016/j.isci.2020.101775
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Jall Sigrid, De Angelis Meri, Lundsgaard Anne-Marie, Fritzen Andreas M., Nicolaisen Trine S., Klein Anders B., Novikoff Aaron, Sachs Stephan, Richter Erik A., Kiens Bente, Schramm Karl-Werner, Tschöp Matthias H., Stemmer Kerstin, Clemmensen Christoffer, Müller Timo D., Kleinert Maximilian. Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity. https://doi.org/10.1007/s00125-020-05117-4
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Mentrup Torben, Cabrera-Cabrera Florencia, Fluhrer Regina, Schröder Bernd. Physiological functions of SPP/SPPL intramembrane proteases. https://doi.org/10.1007/s00018-020-03470-6
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Sachs Stephan, Niu Lili, Geyer Philipp, Jall Sigrid, Kleinert Maximilian, Feuchtinger Annette, Stemmer Kerstin, Brielmeier Markus, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Wewer Albrechtsen Nicolai, Mann Matthias, Müller Timo D., Hofmann Susanna M.. Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice. https://doi.org/10.1111/dom.14215
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Klaus Christine, Hansen Jan N., Ginolhac Aurélien, Gérard Deborah, Gnanapragassam Vinayaga S., Horstkorte Rüdiger, Rossdam Charlotte, Büttner Falk F. R., Sauter Thomas, Sinkkonen Lasse, Neumann Harald, Linnartz-Gerlach Bettina. Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. https://doi.org/10.1016/j.neurobiolaging.2020.01.008
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Papadopoulou Alkmini A., Fluhrer Regina. Signalling functions of intramembrane aspartyl-proteases. https://doi.org/10.3389/fcvm.2020.591787
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Fiebig Timm, Cramer Johannes T., Bethe Andrea, Baruch Petra, Curth Ute, Führing Jana I., Büttner Falk F. R., Vogel Ulrich, Schubert Mario, Fedorov Roman, Mühlenhoff Martina. Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. https://doi.org/10.1038/s41467-020-18464-y
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Starzonek Sarah, Maar Hanna, Labitzky Vera, Wicklein Daniel, Rossdam Charlotte, Büttner Falk F. R., Wolters-Eisfeld Gerrit, Guengoer Cenap, Wagener Christoph, Schumacher Udo, Lange Tobias. Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. https://doi.org/10.1093/glycob/cwaa019
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Fischer Katrin, Fenzl Anna, Liu Dianxin, Dyar Kenneth A., Kleinert Maximilian, Brielmeier Markus, Clemmensen Christoffer, Fedl Anna, Finan Brian, Gessner Andre, Jastroch Martin, Huang Jianfeng, Keipert Susanne, Klingenspor Martin, Brüning Jens C., Kneilling Manfred, Maier Florian C., Othman Ahmed E., Pichler Bernd J., Pramme-Steinwachs Ines, Sachs Stephan, Scheideler Angelika, Thaiss Wolfgang M., Uhlenhaut Henriette, Ussar Siegfried, Woods Stephen C., Zorn Julia, Stemmer Kerstin, Collins Sheila, Diaz-Meco Maria, Moscat Jorge, Tschöp Matthias H., Müller Timo D.. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. https://doi.org/10.1038/s41467-020-16230-8
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Schriever Sonja C., Kabra Dhiraj G., Pfuhlmann Katrin, Baumann Peter, Baumgart Emily V., Nagler Joachim, Seebacher Fabian, Harrison Luke, Irmler Martin, Kullmann Stephanie, Corrêa-da-Silva Felipe, Giesert Florian, Jain Ruchi, Schug Hannah, Castel Julien, Martinez Sarah, Wu Moya, Häring Hans-Ulrich, de Angelis Martin Hrabe, Beckers Johannes, Müller Timo D., Stemmer Kerstin, Wurst Wolfgang, Rozman Jan, Nogueiras Ruben, De Angelis Meri, Molkentin Jeffery D., Krahmer Natalie, Yi Chun-Xia, Schmidt Mathias V., Luquet Serge, Heni Martin, Tschöp Matthias H., Pfluger Paul T.. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. https://doi.org/10.1172/jci136363
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Brugger Manuel S., Baumgartner Kathrin, Mauritz Sophie C. F., Gerlach Stefan C., Röder Florian, Schlosser Christine, Fluhrer Regina, Wixforth Achim, Westerhausen Christoph. Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model. https://doi.org/10.1073/pnas.2005203117
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2019

Rossdam Charlotte, Konze Sarah A., Oberbeck Astrid, Rapp Erdmann, Gerardy-Schahn Rita, von Itzstein Mark, Büttner Falk F. R.. Approach for profiling of glycosphingolipid glycosylation by multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection To identify cell-surface markers of human pluripotent stem cells and derived cardiomyocytes. https://doi.org/10.1021/acs.analchem.9b01114
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Mentrup Torben, Theodorou Kosta, Cabrera-Cabrera Florencia, Helbig Andreas O., Happ Kathrin, Gijbels Marion, Gradtke Ann-Christine, Rabe Björn, Fukumori Akio, Steiner Harald, Tholey Andreas, Fluhrer Regina, Donners Marjo, Schröder Bernd. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. https://doi.org/10.1084/jem.20171438
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Fluhrer Regina, Hampe Wolfgang, editors. Biochemie hoch 2 und Molekularbiologie.
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Albuquerque-Wendt Andreia, Jacot Damien, Dos Santos Pacheco Nicolas, Seegers Carla, Zarnovican Patricia, Büttner Falk F. R., Bakker Hans, Soldati-Favre Dominique, Routier Françoise H.. C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence. https://doi.org/10.1074/jbc.ra119.010590
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Shcherbakova Aleksandra, Preller Matthias, Taft Manuel H., Pujols Jordi, Ventura Salvador, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. C-mannosylation supports folding and enhances stability of thrombospondin repeats. https://doi.org/10.7554/elife.52978
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Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Pfluger Paul T., Tschöp Matthias H.. CNS-targeting pharmacological interventions for the metabolic syndrome. https://doi.org/10.1172/jci129195
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Diekmann Ulf, Wolling Hanna, Dettmer Rabea, Niwolik Isabell, Naujok Ortwin, Büttner Falk F. R.. Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture. https://doi.org/10.1038/s41598-018-37650-z
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Müller Günter A., Herling Andreas W., Stemmer Kerstin, Lechner Andreas, Tschöp Matthias H.. Chip-based sensing for release of unprocessed cell surface proteins in vitro and in serum and its (patho)physiological relevance. https://doi.org/10.1152/ajpendo.00079.2019
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Bastek Heinke, Zubel Tabea, Stemmer Kerstin, Mangerich Aswin, Beneke Sascha, Dietrich Daniel R.. Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. https://doi.org/10.1016/j.tox.2019.03.013
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Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., Fritsche A., Gribble F., Grill H.J., Habener J.F., Holst J.J., Langhans W., Meier J.J., Nauck M.A., Perez-Tilve D., Pocai A., Reimann F., Sandoval D.A., Schwartz T.W., Seeley R.J., Stemmer Kerstin, Tang-Christensen M., Woods S.C., DiMarchi R.D., Tschöp M.H.. Glucagon-like peptide 1 (GLP-1). https://doi.org/10.1016/j.molmet.2019.09.010
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Seitz Susanne, Kwon Yun, Hartleben Götz, Jülg Julia, Sekar Revathi, Krahmer Natalie, Najafi Bahar, Loft Anne, Gancheva Sofiya, Stemmer Kerstin, Feuchtinger Annette, Hrabe de Angelis Martin, Müller Timo D., Mann Matthias, Blüher Matthias, Roden Michael, Berriel Diaz Mauricio, Behrends Christian, Gilleron Jerome, Herzig Stephan, Zeigerer Anja. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. https://doi.org/10.1038/s42255-019-0124-x
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Harger A., Stemmer Kerstin, Tschöp M. H., Müller T. D.. Inkretinbasierte Ko- und Triagonisten: innovative Polypharmakologie zur Behandlung von Adipositas und Diabetes. https://doi.org/10.1007/s00108-019-0649-9
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Fluhrer Regina. Intramembrane proteases in neurodegenerative diseases.
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Fluhrer Regina. Intramembrane proteases in the immune system.
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Konze Sarah A., Abraham Wolf-Rainer, Goethe Elke, Surges Esther, Kuypers Marcel M. M., Hoeltig Doris, Meens Jochen, Vogel Charlotte, Stiesch Meike, Valentin-Weigand Peter, Gerlach Gerald-F., Büttner Falk F. R.. Link between heterotrophic carbon fixation and virulence in the porcine lung pathogen Actinobacillus pleuropneumoniae. https://doi.org/10.1128/iai.00768-18
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Albuquerque-Wendt Andreia, Hütte Hermann J., Büttner Falk F. R., Routier Françoise H., Bakker Hans. Membrane topological model of glycosyltransferases of the GT-C superfamily. https://doi.org/10.3390/ijms20194842
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Niu Lili, Geyer Philipp E, Wewer Albrechtsen Nicolai J, Gluud Lise L, Santos Alberto, Doll Sophia, Treit Peter V, Holst Jens J, Knop Filip K, Vilsbøll Tina, Junker Anders, Sachs Stephan, Stemmer Kerstin, Müller Timo D, Tschöp Matthias H, Hofmann Susanna M, Mann Matthias. Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease. https://doi.org/10.15252/msb.20188793
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Papadopoulou Alkmini A., Müller Stephan A, Mentrup Torben, Shmueli Merav D, Niemeyer Johannes, Haug‐Kröper Martina, von Blume Julia, Mayerhofer Artur, Feederle Regina, Schröder Bernd, Lichtenthaler Stefan F., Fluhrer Regina. Signal peptide peptidase‐like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. https://doi.org/10.15252/embr.201846451
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Niemeyer Johannes, Mentrup Torben, Heidasch Ronny, Müller Stephan A, Biswas Uddipta, Meyer Rieke, Papadopoulou Alkmini A., Dederer Verena, Haug‐Kröper Martina, Adamski Vivian, Lüllmann-Rauch Renate, Bergmann Martin, Mayerhofer Artur, Saftig Paul, Wennemuth Gunther, Jessberger Rolf, Fluhrer Regina, Lichtenthaler Stefan F., Lemberg Marius K, Schröder Bernd. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. https://doi.org/10.15252/embr.201846449
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Fluhrer Regina, Schröder Bernd. What is the role of the intramembrane proteases in cancer?.
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2018

van Diepen Laura, Büttner Falk F. R., Hoffmann Dirk, Thiesler Christina T., von Bohlen und Halbach Oliver, von Bohlen und Halbach Viola, Jensen Lars R., Steinemann Doris, Edvardson Simon, Elpeleg Orly, Schambach Axel, Gerardy-Schahn Rita, Kuss Andreas W.. A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency. https://doi.org/10.1038/s41431-018-0220-5
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Stumpp Nico S., Konze Sarah A., Gerardy-Schahn Rita, Stiesch Meike, Büttner Falk F. R.. A single-step transconjugation system for gene deletion in Aggregatibacter actinomycetemcomitans. https://doi.org/10.1016/j.mimet.2018.04.002
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Fluhrer Regina. A unique family of intramembrane proteases. https://doi.org/10.26320/SCIENTIA179
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Hoppe Carolin M., Albuquerque-Wendt Andreia, Bandini Giulia, Leon Deborah R., Shcherbakova Aleksandra, Büttner Falk F. R., Izquierdo Luis, Costello Catherine E., Bakker Hans, Routier Françoise H.. Apicomplexan C-mannosyltransferases modify thrombospondin type I-containing adhesins of the TRAP family. https://doi.org/10.1093/glycob/cwy013
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Rahn Sascha, Zimmermann Vivien, Viol Fabrice, Knaack Hendrike, Stemmer Kerstin, Peters Lena, Lenk Lennart, Ungefroren Hendrik, Saur Dieter, Schäfer Heiner, Helm Ole, Sebens Susanne. Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells. https://doi.org/10.1016/j.canlet.2017.12.004
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Fluhrer Regina. Health report: the challenge of cleaving proteins in the membrane.
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Fluhrer Regina. Intramembrane proteases - regulators of cellular pathways.
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Brandt S. J., Müller T. D., DiMarchi R. D., Tschöp M. H., Stemmer Kerstin. Peptide-based multi-agonists: a new paradigm in metabolic pharmacology. https://doi.org/10.1111/joim.12837
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Lichtenthaler Stefan F., Lemberg Marius K., Fluhrer Regina. Proteolytic ectodomain shedding of membrane proteins in mammals - hardware, concepts, and recent developments. https://doi.org/10.15252/embj.201899456
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Wolling Hanna, Konze Sarah A., Höfer Anne, Erdmann Jelena, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Quantitative secretomics reveals extrinsic signals involved in human pluripotent stem cell cardiomyogenesis. https://doi.org/10.1002/pmic.201800102
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Pandey Ashutosh, Li-Kroeger David, Sethi Maya K., Lee Tom V., Büttner Falk F. R., Bakker Hans, Jafar-Nejad Hamed. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila notch signaling. https://doi.org/10.1093/glycob/cwy080
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2017

Kommerein Nadine, Stumpp Sascha N., Müsken Mathias, Ehlert Nina, Winkel Andreas, Häussler Susanne, Behrens Peter, Büttner Falk F. R., Stiesch Meike. An oral multispecies biofilm model for high content screening applications. https://doi.org/10.1371/journal.pone.0173973
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Böer Ulrike, Büttner Falk F. R., Schridde Ariane, Klingenberg Melanie, Sarikouch Samir, Haverich Axel, Wilhelmi Mathias. Antibody formation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissue proteins and αGal epitopes and is reduced in healthy vegetarian subjects. https://doi.org/10.1111/xen.12288
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Jules Felix, Sauvageau Etienne, Dumaresq-Doiron Karine, Mazzaferri Javier, Haug-Kröper Martina, Fluhrer Regina, Costantino Santiago, Lefrancois Stephane. CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein. https://doi.org/10.1016/j.yexcr.2017.04.024
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Diekmann Ulf, Wolling Hanna, Büttner Falk F. R., Naujok Ortwin. Chemisch-definierte und xenogen-freie Differenzierung humaner embryonaler Stammzellen in endodermale und pankreatische Vorläuferzellen. https://doi.org/10.1055/s-0037-1601586
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Ryan Karen K, Packard Amy E B, Larson Karlton R, Stout Jayna, Fourman Sarah M, Thompson Abigail M K, Ludwick Kristen, Habegger Kirk M, Stemmer Kerstin, Itoh Nobuyuki, Perez-Tilve Diego, Tschöp Matthias H, Seeley Randy J, Ulrich-Lai Yvonne M. Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21. https://doi.org/10.1210/en.2017-00486
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Scilabra Simone D., Yamamoto Kazuhiro, Pigoni Martina, Sakamoto Kazuma, Müller Stephan A., Papadopoulou Alkmini A., Lichtenthaler Stefan F., Troeberg Linda, Nagase Hideaki, Kadomatsu Kenji. Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue. https://doi.org/10.1016/j.matbio.2016.07.004
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Shcherbakova Aleksandra, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. https://doi.org/10.1073/pnas.1613165114
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Pfuhlmann Katrin, Pfluger Paul T., Schriever Sonja C., Müller Timo D., Tschöp Matthias H., Stemmer Kerstin. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. https://doi.org/10.1371/journal.pone.0183488
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Kleinert Maximilian, Clemmensen Christoffer, Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Tschöp Matthias H.. Emerging poly-agonists for obesity and Type 2 Diabetes. https://doi.org/10.1002/oby.21932
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Mentrup Torben, Fluhrer Regina, Schröder Bernd. Latest emerging functions of SPP/SPPL intramembrane proteases. https://doi.org/10.1016/j.ejcb.2017.03.002
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Konze Sarah A., Werneburg Sebastian, Oberbeck Astrid, Olmer Ruth, Kempf Henning, Jara-Avaca Monica, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Proteomic analysis of human pluripotent stem cell cardiomyogenesis revealed altered expression of metabolic enzymes and PDLIM5 isoforms. https://doi.org/10.1021/acs.jproteome.6b00534
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Konze Sarah A., Cajic Samanta, Oberbeck Astrid, Hennig René, Pich Andreas, Rapp Erdmann, Büttner Falk F. R.. Quantitative assessment of Sialo‐glycoproteins and N‐Glycans during cardiomyogenic differentiation of human induced pluripotent stem cells. https://doi.org/10.1002/cbic.201700100
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Mentrup Torben, Loock Ann-Christine, Fluhrer Regina, Schröder Bernd. Signal peptide peptidase and SPP-like proteases: possible therapeutic targets?. https://doi.org/10.1016/j.bbamcr.2017.06.007
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Giles Daniel A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Graspeuntner Simon, Cappelletti Monica, Wu David, Mukherjee Rajib, Chan Calvin C, Lawson Matthew J, Klarquist Jared, Sünderhauf Annika, Softic Samir, Kahn C Ronald, Stemmer Kerstin, Iwakura Yoichiro, Aronow Bruce J, Karns Rebekah, Steinbrecher Kris A, Karp Christopher L, Sheridan Rachel, Shanmukhappa Shiva K, Reynaud Damien, Haslam David B, Sina Christian, Rupp Jan, Hogan Simon P, Divanovic Senad. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. https://doi.org/10.1038/nm.4346
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Erratum: Nature Medicine 23, 1241 (2017), DOI 10.1038/nm1017-1241c
Klaus Valentina, Bastek Heinke, Damme Katja, Collins Leonard B., Frötschl Roland, Benda Norbert, Lutter Dominik, Ellinger-Ziegelbauer Heidrun, Swenberg James A., Dietrich Daniel R., Stemmer Kerstin. Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats. https://doi.org/10.1007/s00204-017-1953-6
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2016

Maida Adriano, Zota Annika, Sjøberg Kim A., Schumacher Jonas, Sijmonsma Tjeerd P., Pfenninger Anja, Christensen Marie M., Gantert Thomas, Fuhrmeister Jessica, Rothermel Ulrike, Schmoll Dieter, Heikenwälder Mathias, Iovanna Juan L., Stemmer Kerstin, Kiens Bente, Herzig Stephan, Rose Adam J.. A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution. https://doi.org/10.1172/jci85946
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Kempf Henning, Olmer Ruth, Haase Alexandra, Franke Annika, Bolesani Emiliano, Schwanke Kristin, Robles-Diaz Diana, Coffee Michelle, Göhring Gudrun, Dräger Gerald, Pötz Oliver, Joos Thomas, Martinez-Hackert Erik, Haverich Axel, Büttner Falk F. R., Martin Ulrich, Zweigerdt Robert. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. https://doi.org/10.1038/ncomms13602
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Finan Brian, Clemmensen Christoffer, Zhu Zhimeng, Stemmer Kerstin, Gauthier Karine, Müller Luisa, De Angelis Meri, Moreth Kristin, Neff Frauke, Perez-Tilve Diego, Fischer Katrin, Lutter Dominik, Sánchez-Garrido Miguel A., Liu Peng, Tuckermann Jan, Malehmir Mohsen, Healy Marc E., Weber Achim, Heikenwalder Mathias, Jastroch Martin, Kleinert Maximilian, Jall Sigrid, Brandt Sara, Flamant Frédéric, Schramm Karl-Werner, Biebermann Heike, Döring Yvonne, Weber Christian, Habegger Kirk M., Keuper Michaela, Gelfanov Vasily, Liu Fa, Köhrle Josef, Rozman Jan, Fuchs Helmut, Gailus-Durner Valerie, Hrabě de Angelis Martin, Hofmann Susanna M., Yang Bin, Tschöp Matthias H., DiMarchi Richard, Müller Timo D.. Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease. https://doi.org/10.1016/j.cell.2016.09.014
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Thiesler Christina T., Cajic Samanta, Hoffmann Dirk, Thiel Christian, van Diepen Laura, Hennig René, Sgodda Malte, Weiβmann Robert, Reichl Udo, Steinemann Doris, Diekmann Ulf, Huber Nicolas M. B., Oberbeck Astrid, Cantz Tobias, Kuss Andreas W., Körner Christian, Schambach Axel, Rapp Erdmann, Büttner Falk F. R.. Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG). https://doi.org/10.1074/mcp.m115.054122
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Kabra Dhiraj G., Pfuhlmann Katrin, García-Cáceres Cristina, Schriever Sonja C., Casquero García Veronica, Kebede Adam Fiseha, Fuente-Martin Esther, Trivedi Chitrang, Heppner Kristy, Uhlenhaut N. Henriette, Legutko Beata, Kabra Uma D., Gao Yuanqing, Yi Chun-Xia, Quarta Carmelo, Clemmensen Christoffer, Finan Brian, Müller Timo D., Meyer Carola W., Paez-Pereda Marcelo, Stemmer Kerstin, Woods Stephen C., Perez-Tilve Diego, Schneider Robert, Olson Eric N., Tschöp Matthias H., Pfluger Paul T.. Hypothalamic leptin action is mediated by histone deacetylase 5. https://doi.org/10.1038/ncomms10782
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Behrens Wiebke, Schweinitzer Tobias, McMurry Jonathan L., Loewen Peter C., Büttner Falk F. R., Menz Sarah, Josenhans Christine. Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions. https://doi.org/10.1038/srep23582
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Werneburg Sebastian, Büttner Falk F. R., Erben Larisser, Mathews Mona, Neumann Harald, Mühlenhoff Martina, Hildebrandt Herbert. Polysialylation and lipopolysaccharide‐induced shedding of E‐selectin ligand‐1 and neuropilin‐2 by microglia and THP‐1 macrophages. https://doi.org/10.1002/glia.23004
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Hüttl Susann, Helfrich F., Mentrup Torben, Held S., Fukumori Akio, Steiner Harald, Saftig Paul, Fluhrer Regina, Schroder B.. Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. https://doi.org/10.1042/bcj20160156
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2015

Baumann Anna-Maria T., Bakkers Mark J. G., Büttner Falk F. R., Hartmann Maike, Grove Melanie, Langereis Martijn A., de Groot Raoul J., Mühlenhoff Martina. 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. https://doi.org/10.1038/ncomms8673
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Mentrup Torben, Häsler Robert, Fluhrer Regina, Saftig Paul, Schröder Bernd. A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases. https://doi.org/10.1111/tra.12287
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Krüger Anke Tina, Engel Jakob, Büttner Falk F. R., Routier Françoise H.. Aspergillus fumigatus Cap59-like protein A is involved in α1,3-mannosylation of GPI-anchors. https://doi.org/10.1093/glycob/cwv078
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Engel Jakob, Schmalhorst Philipp S., Krüger Anke Tina, Müller Christina Theda, Büttner Falk F. R., Routier Françoise H. Characterization of an N-acetylglucosaminyltransferase involved in Aspergillus fumigatus zwitterionic glycoinositolphosphoceramide biosynthesis. https://doi.org/10.1093/glycob/cwv059
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Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Lüder Carsten G. K., Ferguson Michael A. J., Routier Françoise H.. Depletion of UDP-glucose and UDP-galactose using a Degron system leads to growth cessation of Leishmania major. https://doi.org/10.1371/journal.pntd.0004205
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Karsten Christina B., Büttner Falk F. R., Cajic Samanta, Nehlmeier Inga, Neumann Berit, Klippert Antonina, Sauermann Ulrike, Reichl Udo, Gerardy-Schahn Rita, Rapp Erdmann, Stahl-Hennig Christiane, Pöhlmann Stefan. Exclusive decoration of Simian Immunodeficiency Virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in Rhesus Macaques. https://doi.org/10.1128/jvi.01358-15
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Stemmer Kerstin, Zani Fabio, Habegger Kirk M., Neff Christina, Kotzbeck Petra, Bauer Michaela, Yalamanchilli Suma, Azad Ali, Lehti Maarit, Martins Paulo J. F., Müller Timo D., Pfluger Paul T., Seeley Randy J.. FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice. https://doi.org/10.1007/s00125-015-3668-7
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Werneburg S., Büttner Falk F. R., Stangel M., Mühlenhoff M., Hildebrandt H.. ISDN2014_0137: NG2 cells and microglia show cell‐type specific expression of polysialic acid attached to different protein carriers. https://doi.org/10.1016/j.ijdevneu.2015.04.112
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Kamp Frits, Winkler Edith, Trambauer Johannes, Ebke Amelie, Fluhrer Regina, Steiner Harald. Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process. https://doi.org/10.1016/j.bpj.2014.12.045
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Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Ferguson Michael A. J., Routier Françoise H.. Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis. https://doi.org/10.1016/j.ijpara.2015.06.004
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Werneburg Sebastian, Büttner Falk F. R., Mühlenhoff Martina, Hildebrandt Herbert. Polysialic acid modification of the synaptic cell adhesion molecule SynCAM 1 in human embryonic stem cell-derived oligodendrocyte precursor cells. https://doi.org/10.1016/j.scr.2015.03.001
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Fleck Daniel, Voss Matthias, Brankatschk Ben, Giudici Camilla, Hampel Heike, Schwenk Benjamin, Edbauer Dieter, Fukumori Akio, Steiner Harald, Kremmer Elisabeth, Haug-Kröper Martina, Rossner Moritz J., Fluhrer Regina, Willem Michael, Haass Christian. Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases. https://doi.org/10.1074/jbc.m115.697995
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Kuhn Peer-Hendrik, Voss Matthias, Haug-Kröper Martina, Schröder Bernd, Schepers Ute, Bräse Stefan, Haass Christian, Lichtenthaler Stefan F., Fluhrer Regina. Secretome analysis identifies novel signal peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. https://doi.org/10.1074/mcp.m115.048298
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Dargel Christina, Bassani-Sternberg Michal, Hasreiter Julia, Zani Fabio, Bockmann Jan-Hendrik, Thiele Frank, Bohne Felix, Wisskirchen Karin, Wilde Susanne, Sprinzl Martin F., Schendel Dolores J., Krackhardt Angela M., Uckert Wolfgang, Wohlleber Dirk, Schiemann Matthias, Stemmer Kerstin, Heikenwälder Mathias, Busch Dirk H., Richter Günther, Mann Matthias, Protzer Ulrike. T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice. https://doi.org/10.1053/j.gastro.2015.05.055
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2014

Fluhrer Regina. Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins. https://doi.org/10.4161/cc.28089
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Wolf Monika Julia, Adili Arlind, Piotrowitz Kira, Abdullah Zeinab, Boege Yannick, Stemmer Kerstin, Ringelhan Marc, Simonavicius Nicole, Egger Michèle, Wohlleber Dirk, Lorentzen Anna, Einer Claudia, Schulz Sabine, Clavel Thomas, Protzer Ulrike, Thiele Christoph, Zischka Hans, Moch Holger, Tschöp Matthias, Tumanov Alexei V., Haller Dirk, Unger Kristian, Karin Michael, Kopf Manfred, Knolle Percy, Weber Achim, Heikenwalder Mathias. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. https://doi.org/10.1016/j.ccell.2014.09.003
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Voss Matthias, Künzel Ulrike, Higel Fabian, Kuhn Peer‐Hendrik, Colombo Alessio, Fukumori Akio, Haug‐Kröper Martina, Klier Bärbel, Grammer Gudula, Seidl Andreas, Schröder Bernd, Obst Reinhard, Steiner Harald, Lichtenthaler Stefan F., Haass Christian, Fluhrer Regina. Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation. https://doi.org/10.15252/embj.201488375
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Schneppenheim Janna, Hüttl Susann, Kruchen Anne, Fluhrer Regina, Müller Ingo, Saftig Paul, Schneppenheim Reinhard, Martin Christa L., Schröder Bernd. Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. https://doi.org/10.1016/j.bbrc.2014.07.051
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Brockmann Anette, Strittmatter Tobias, May Sarah, Stemmer Kerstin, Marx Andreas, Brunner Thomas. Structure–function relationship of thiazolide-induced apoptosis in colorectal tumor cells. https://doi.org/10.1021/cb500209a
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Schneppenheim Janna, Hüttl Susann, Mentrup Torben, Lüllmann-Rauch Renate, Rothaug M., Engelke Michael, Dittmann Kai, Dressel Ralf, Araki M., Araki K., Wienands Jürgen, Fluhrer Regina, Saftig Paul, Schroder B.. The intramembrane proteases signal peptide peptidase-like 2a and 2b have distinct functions in vivo. https://doi.org/10.1128/mcb.00038-14
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Stemmer Kerstin, Kotzbeck P, Zani F, Bauer M, Neff C, Müller T D, Pfluger P T, Seeley R J, Divanovic S. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. https://doi.org/10.1038/ijo.2014.187
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2013

Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. https://doi.org/10.1016/j.yrtph.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. https://doi.org/10.1016/j.fct.2013.07.005
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Habegger K. M., Stemmer Kerstin, Cheng C., Muller T. D., Heppner K. M., Ottaway N., Holland J., Hembree J. L., Smiley D., Gelfanov V., Krishna R., Arafat A. M., Konkar A., Belli S., Kapps M., Woods S. C., Hofmann S. M., D'Alessio D., Pfluger P. T., Perez-Tilve D., Seeley R. J., Konishi M., Itoh N., Kharitonenkov A., Spranger J., DiMarchi R. D., Tschop M. H.. Fibroblast growth factor 21 mediates specific glucagon actions. https://doi.org/10.2337/db12-1116
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Bielohuby Maximilian, Sisley Stephanie, Sandoval Darleen, Herbach Nadja, Zengin Ayse, Fischereder Michael, Menhofer Dominik, Stoehr Barbara J. M., Stemmer Kerstin, Wanke Rüdiger, Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. https://doi.org/10.1152/ajpendo.00208.2013
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Voss Matthias, Schröder Bernd, Fluhrer Regina. Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. https://doi.org/10.1016/j.bbamem.2013.03.033
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Dietrich Daniel, von Aulock Sonja, Marquardt H. W. J., Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan G., Collier Abby C., Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Open letter to the European commission: scientifically unfounded precaution drives European commission’s recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles. https://doi.org/10.1007/s00204-013-1117-2
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Poggi Marjorie, Kara Imène, Brunel Jean-Michel, Landrier Jean-François, Govers Roland, Bonardo Bernadette, Fluhrer Regina, Haass Christian, Alessi Marie-Christine, Peiretti Franck. Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling. https://doi.org/10.1016/j.bbamcr.2012.11.009
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Stemmer Kerstin, Bielohuby Maximilian, Grayson Bernadette E., Begg Denovan P., Chambers Adam P., Neff Christina, Woods Stephen C., Erben Reinhold G., Tschöp Matthias H., Bidlingmaier Martin, Clemens Thomas L., Seeley Randy J.. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. https://doi.org/10.1210/en.2012-2130
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan, Barile Frank A.. Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. https://doi.org/10.1016/j.toxicon.2013.10.020
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Barile Frank A., Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. https://doi.org/10.1016/j.cbi.2013.07.001
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Wallace Hayes A., Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. https://doi.org/10.1016/j.tiv.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. https://doi.org/10.14573/altex.2013.3.381
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Bronckers Antonius LJJ, Gueneli Nur, Lüllmann-Rauch Renate, Schneppenheim Janna, Moraru Andreea P, Himmerkus Nina, Bervoets Theodore J, Fluhrer Regina, Everts Vincent, Saftig Paul, Schröder Bernd. The intramembrane protease SPPL2A is critical for tooth enamel formation. https://doi.org/10.1002/jbmr.1895
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Müller Timo D., Müller Anne, Yi Chun-Xia, M Habegger Kirk, Meyer Carola W., Gaylinn Bruce D., Finan Brian, Heppner Kristy, Trivedi Chitrang, Bielohuby Maximilian, Abplanalp William, Meyer Franziska, Piechowski Carolin L., Pratzka Juliane, Stemmer Kerstin, Holland Jenna, Hembree Jazzmin, Bhardwaj Nakul, Raver Christine, Ottaway Nickki, Krishna Radha, Sah Renu, Sallee Floyd R., Woods Stephen C., Perez-Tilve Diego, Bidlingmaier Martin, Thorner Michael O., Krude Heiko, Smiley David, DiMarchi Richard, Hofmann Susanna, Pfluger Paul T., Kleinau Gunnar, Biebermann Heike, Tschöp Matthias H.. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. https://doi.org/10.1038/ncomms2968
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Zahn Claudia, Kaup Matthias, Fluhrer Regina, Fuchs Hendrik. The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. https://doi.org/10.1111/febs.12176
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2012

Voss Matthias, Fukumori Akio, Kuhn Peer-Hendrik, Künzel Ulrike, Klier Bärbel, Grammer Gudula, Haug-Kröper Martina, Kremmer Elisabeth, Lichtenthaler Stefan F., Steiner Harald, Schröder Bernd, Haass Christian, Fluhrer Regina. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). https://doi.org/10.1074/jbc.m112.371369
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Stemmer Kerstin, Perez-Tilve Diego, Ananthakrishnan Gayathri, Bort Anja, Seeley Randy J., Tschöp Matthias H., Dietrich Daniel R., Pfluger Paul T.. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. https://doi.org/10.1242/dmm.009407
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Okle Oliver, Stemmer Kerstin, Deschl Ulrich, Dietrich Daniel R.. L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations. https://doi.org/10.1093/toxsci/kfs291
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Finan Brian, Yang Bin, Ottaway Nickki, Stemmer Kerstin, Müller Timo D, Yi Chun-Xia, Habegger Kirk, Schriever Sonja C, García-Cáceres Cristina, Kabra Dhiraj G, Hembree Jazzminn, Holland Jenna, Raver Christine, Seeley Randy J, Hans Wolfgang, Irmler Martin, Beckers Johannes, de Angelis Martin Hrabě, Tiano Joseph P, Mauvais-Jarvis Franck, Perez-Tilve Diego, Pfluger Paul, Zhang Lianshan, Gelfanov Vasily, DiMarchi Richard D, Tschöp Matthias H. Targeted estrogen delivery reverses the metabolic syndrome. https://doi.org/10.1038/nm.3009
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Schneppenheim Janna, Dressel Ralf, Hüttl Susann, Lüllmann-Rauch Renate, Engelke Michael, Dittmann Kai, Wienands Jürgen, Eskelinen Eeva-Liisa, Hermans-Borgmeyer Irm, Fluhrer Regina, Saftig Paul, Schröder Bernd. The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. https://doi.org/10.1084/jem.20121069
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Müller Timo D., Lee Sang Jun, Jastroch Martin, Kabra Dhiraj, Stemmer Kerstin, Aichler Michaela, Abplanalp Bill, Ananthakrishnan Gayathri, Bhardwaj Nakul, Collins Sheila, Divanovic Senad, Endele Max, Finan Brian, Gao Yuanqing, Habegger Kirk M., Hembree Jazzmin, Heppner Kristy M., Hofmann Susanna, Holland Jenna, Küchler Daniela, Kutschke Maria, Krishna Radha, Lehti Maarit, Oelkrug Rebecca, Ottaway Nickki, Perez-Tilve Diego, Raver Christine, Walch Axel K., Schriever Sonja C., Speakman John, Tseng Yu-Hua, Diaz-Meco Maria, Pfluger Paul T., Moscat Jorge, Tschöp Matthias H.. p62 Links β-adrenergic input to mitochondrial function and thermogenesis. https://doi.org/10.1172/jci64209
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2011

Stemmer Kerstin, Dietrich Daniel R.. Application of laser-capture microdissection to study renal carcinogenesis. https://doi.org/10.1007/978-1-61779-163-5_23
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Bielohuby Maximilian, Stemmer Kerstin, Berger José, Ramisch Juliane, Smith Kathleen, Holland Jenna, Parks Kenneth, Pfluger Paul T., Habegger Kirk M., Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. https://doi.org/10.1007/s11695-011-0528-5
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Feurstein Daniel, Stemmer Kerstin, Kleinteich Julia, Speicher Tobias, Dietrich Daniel R. Microcystin congener– and concentration-dependent induction of murine neuron apoptosis and neurite degeneration. https://doi.org/10.1093/toxsci/kfr243
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Fluhrer Regina, Kamp Frits, Grammer Gudula, Nuscher Brigitte, Steiner Harald, Beyer Klaus, Haass Christian. The nicastrin ectodomain adopts a highly thermostable structure. https://doi.org/10.1515/bc.2011.169
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Fluhrer Regina, Martin Lucas, Klier Bärbel, Haug-Kröper Martina, Grammer Gudula, Nuscher Brigitte, Haass Christian. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). https://doi.org/10.1074/jbc.m111.328104
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2010

Bielohuby Maximilian, Menhofer Dominik, Kirchner Henriette, Stoehr Barbara J. M., Müller Timo D., Stock Peggy, Hempel Madlen, Stemmer Kerstin, Pfluger Paul T., Kienzle Ellen, Christ Bruno, Tschöp Matthias H., Bidlingmaier Martin. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. https://doi.org/10.1152/ajpendo.00478.2010
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Feurstein Daniel, Kleinteich Julia, Heussner Alexandra H., Stemmer Kerstin, Dietrich Daniel R.. Investigation of microcystin congener–dependent uptake into primary murine neurons. https://doi.org/10.1289/ehp.0901289
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Fischer A., Hoeger S.J., Stemmer Kerstin, Feurstein D.J., Knobeloch D., Nussler A., Dietrich D.R.. The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells. https://doi.org/10.1016/j.taap.2010.02.006
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Fukumori Akio, Fluhrer Regina, Steiner Harald, Haass Christian. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. https://doi.org/10.1523/jneurosci.1443-10.2010
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2009

Godemann Robert, Madden James, Krämer Joachim, Smith Myron, Fritz Ulrike, Hesterkamp Thomas, Barker John, Höppner Sabine, Hallett David, Cesura Andrea, Ebneth Andreas, Kemp John. Fragment-based discovery of BACE1 inhibitors using functional assays. https://doi.org/10.1021/bi901061a
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Fluhrer Regina, Steiner Harald, Haass Christian. Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. https://doi.org/10.1074/jbc.r800040200
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Fluhrer Regina, Haass Christian. Intramembrane proteolysis by γ-secretase and signal peptide peptidases. https://doi.org/10.1007/978-3-540-87941-1_2
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Jürgen, Dietrich Daniel R.. Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors. https://doi.org/10.2353/ajpath.2009.081071
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Martin Lucas, Fluhrer Regina, Haass Christian. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. https://doi.org/10.1074/jbc.m807485200
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2008

Steiner Harald, Fluhrer Regina, Haass Christian. Intramembrane proteolysis by γ-secretase. https://doi.org/10.1074/jbc.r800010200
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Fluhrer Regina, Fukumori Akio, Martin Lucas, Grammer Gudula, Haug-Kröper Martina, Klier Bärbel, Winkler Edith, Kremmer Elisabeth, Condron Margaret M., Teplow David B., Steiner Harald, Haass Christian. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. https://doi.org/10.1074/jbc.m806092200
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2007

Prager Kai, Wang-Eckhardt Lihua, Fluhrer Regina, Killick Richard, Barth Esther, Hampel Heike, Haass Christian, Walter Jochen. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. https://doi.org/10.1074/jbc.m608437200
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Juergen, Dietrich Daniel R.. Carcinogen-specific gene expression profiles in short-term treated eker and wild-type rats indicative of pathways involved in renal tumorigenesis. https://doi.org/10.1158/0008-5472.can-06-3587
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Martin Lucas, Fluhrer Regina, Reiss Karina, Kremmer Elisabeth, Saftig Paul, Haass Christian. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. https://doi.org/10.1074/jbc.m706661200
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Fluhrer Regina, Haass Christian. Signal peptide peptidases and gamma-secretase: cousins of the same protease family?. https://doi.org/10.1159/000101835
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2006

Fluhrer Regina, Grammer Gudula, Israel Lars, Condron Margaret M., Haffner Christof, Friedmann Elena, Böhland Claudia, Imhof Axel, Martoglio Bruno, Teplow David B., Haass Christian. A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b. https://doi.org/10.1038/ncb1450
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Lotz Kerstin, Ahr Hans-J., Dietrich Daniel R.. Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips. https://doi.org/10.1016/j.taap.2006.07.012
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Larivière Laurent, Geiger Sebastian, Hoeppner Sabine, Röther Susanne, Sträßer Katja, Cramer Patrick. Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20. https://doi.org/10.1038/nsmb1143
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2005

Baumli Sonja, Hoeppner Sabine, Cramer Patrick. A conserved mediator hinge revealed in the structure of the MED7·MED21 (Med7·Srb7) heterodimer. https://doi.org/10.1074/jbc.m413466200
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Meinhart Anton, Kamenski Tomislav, Hoeppner Sabine, Baumli Sonja, Cramer Patrick. A structural perspective of CTD function. https://doi.org/10.1101/gad.1318105
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Baltes Nina, N′diaye Mohamed, Jacobsen Ilse D., Maas Alexander, Büttner Falk F. R., Gerlach Gerald-F.. Deletion of the anaerobic regulator HlyX causes reduced colonization and persistence of Actinobacillus pleuropneumoniae in the porcine respiratory tract. https://doi.org/10.1128/iai.73.8.4614-4619.2005
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Krawitz Peter, Haffner Christof, Fluhrer Regina, Steiner Harald, Schmid Bettina, Haass Christian. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. https://doi.org/10.1074/jbc.m501645200
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Hoeppner Sabine, Baumli Sonja, Cramer Patrick. Structure of the Mediator subunit cyclin C and its implications for CDK8 function. https://doi.org/10.1016/j.jmb.2005.05.041
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Höppner Christoph, Carle Anna, Sivanesan Durga, Hoeppner Sabine, Baron Christian. The putative lytic transglycosylase VirB1 from Brucella suis interacts with the type IV secretion system core components VirB8, VirB9 and VirB11. https://doi.org/10.1099/mic.0.28326-0
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2003

Fluhrer Regina, Multhaup Gerd, Schlicksupp Andrea, Okochi Masayasu, Takeda Masatoshi, Lammich Sven, Willem Michael, Westmeyer Gil, Bode Wolfram, Walter Jochen, Haass Christian. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. https://doi.org/10.1074/jbc.m211485200
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Fluhrer Regina, Friedlein Arno, Haass Christian, Walter Jochen. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. https://doi.org/10.1074/jbc.m306653200
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Fluhrer Regina. Zwei neuartige Aspartylproteasen BACE-1 und BACE-2: Charakterisierung und Vergleich der katalytischen Spezifitäten bei der Proteolyse des Alzheimer-β-Amyloid-Vorläufer-Proteins.
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München, Univ., Diss., 2003

2002

Fluhrer Regina, Capell Anja, Westmeyer Gil, Willem Michael, Hartung Bianka, Condron Margaret M., Teplow David B., Haass Christian, Walter Jochen. A non-amyloidogenic function of BACE-2 in the secretory pathway. https://doi.org/10.1046/j.1471-4159.2002.00908.x
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Capell Anja, Meyn Liane, Fluhrer Regina, Teplow David B., Walter Jochen, Haass Christian. Apical sorting of beta-secretase limits amyloid beta-peptide production. https://doi.org/10.1074/jbc.m109119200
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2001

Walter Jochen, Fluhrer Regina, Hartung Bianka, Willem Michael, Kaether Christoph, Capell Anja, Lammich Sven, Multhaup Gerd, Haass Christian. Phosphorylation regulates intracellular trafficking of beta-secretase. https://doi.org/10.1074/jbc.m011116200
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